Open access peer-reviewed Edited Volume


Molecular Biology, Clinical and Pharmaceutical Approaches


Carol Davila University of Medicine and Pharmacy


Alina Crenguţa Nicolae

Carol Davila University of Medicine and Pharmacy

Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.

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MelatoninMolecular Biology, Clinical and Pharmaceutical ApproachesEdited by CRISTINA MANUELA DRĂGOI

Published: November 21st 2018

DOI: 10.5772/intechopen.74993

ISBN: 978-1-78984-505-1

Print ISBN: 978-1-78984-504-4

eBook (PDF) ISBN: 978-1-83881-812-8

Copyright year: 2018

Books open for chapter submissions

7618 Total Chapter Downloads

20 Crossref Citations

19 Web of Science Citations

34 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Melatonin, the Integrative Molecule within the Human Architecture

By Cristina Manuela Drăgoi and Alina Crenguța Nicolae


Open access peer-reviewed

2. How Can Molecular Pharmacology Help Understand the Multiple Actions of Melatonin: 20 Years of Research and Trends

By Jean A. Boutin


Open access peer-reviewed

3. An Overview of Melatonin as an Antioxidant Molecule: A Biochemical Approach

By Aysun Hacışevki and Burcu Baba


Open access peer-reviewed

4. Melatonin and Its Indisputable Effects on the Health State

By Hanan Farouk Aly and Maha Zaki Rizk


Open access peer-reviewed

5. Melatonin and Exercise: Their Effects on Malondialdehyde and Lipid Peroxidation

By Mahsa Rastegar Moghaddam Mansouri, Sadegh Abbasian and Mohammad Khazaie


Open access peer-reviewed

6. Melatonin in Childhood Epilepsy and in Child Neurology

By Justyna Paprocka, Marek Kijonka and Maria Sokół


Open access peer-reviewed

7. Measurement of Plasma Tryptophan Metabolites: Clinical and Experimental Application for Depression and Stress States Assessment

By Akikazu Takada, Fumiko Shimizu and Junichi Masuda


Open access peer-reviewed

8. Salivary Melatonin at Night: Responding to the Night Lighting and Cow’s Milk Consumption at Breakfast in Japanese Junior High and University Students

By Hitomi Takeuchi and Tetsuo Harada


Open access peer-reviewed

9. Melatonin Modified Release Formulations Designed for Sleep Disorders

By Marilena Vlachou and Angeliki Siamidi


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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