Open access peer-reviewed Edited Volume

Medicinal Chemistry

Edited by Janka Vašková

Pavol Jozef Safarik University in Kosice

Co-editor:

The area covered by this book undoubtedly includes a multidisciplinary approach. It combines and uses the wide range of methods and knowledge from a variety of disciplines in chemistry, pharmacology, and biology to synthesize new or extracted natural substances and their characterization, in terms of bioefficiency in different systems, pharmacokinetics, and pharmacodynamics. Importance is placed on revealing the interactions and effects on organisms. The process is long term, ranging from synthesis to potential testing of substances in animal studies, followed by monitoring effects on patients. The purpose is to define molecular targets of the highest efficacy of the prepared drugs, minimizing the undesirable effects. The content of this book is conceived with these intentions.

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Medicinal ChemistryEdited by Janka Vašková

Published: March 13th 2019

ISBN: 978-1-78985-174-8

Print ISBN: 978-1-78985-173-1

Copyright year: 2019

Books open for chapter submissions

854 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Unregulated Mitochondrial Production of Reactive Oxygen Species in Testing the Biological Activity of Compounds

By Janka Vašková and Ladislav Vaško

26

Open access peer-reviewed

2. Determination of In Vitro Cytotoxicity and Anti-Angiogenesis for a Bioactive Compound from Aspergillus terreus FC36AY1 Isolated from Aegle marmelos around Western Ghats, India

By Vellingiri Manon Mani, Arockiam Jeyasundar Parimala Gnana Soundari and Selvam Tamilarasi

147

Open access peer-reviewed

3. The Apoptotic Effects of Methylparaben and Ultraviolet B Light on M624 Human Melanoma Cells

By Rebekah S. Wood, Rebecca S. Greenstein, Isabella M. Hildebrandt and Kimberly S. George Parsons

69

Open access peer-reviewed

4. Indomethacin from Anti-Inflammatory to Anticancer Agent

By Shaymaa Emam Kassab

211

Open access peer-reviewed

5. 1,4-Benzodiazepines and New Derivatives: Description, Analysis, and Organic Synthesis

By Elisabet Batlle, Enric Lizano, Miquel Viñas and Maria Dolors Pujol

137

Open access peer-reviewed

6. Clinical Pharmacokinetics of Clavulanic Acid, a Novel β- Lactamase Isolated from Streptomyces clavuligerus and Its Variability

By Anab Fatima, Mohammad Jiyad Shaikh, Hina Zahid, Ishart Younus, Sheikh Abdul Khaliq and Farah Khalid

62

Open access peer-reviewed

7. New Antituberculosis Drug FS-1

By Rinat Islamov, Bahkytzhan Kerimzhanova and Alexander Ilin

59

Open access peer-reviewed

8. Clinical Relevance of Medicinal Plants and Foods of Vegetal Origin on the Activity of Cytochrome P450

By Xóchitl S. Ramírez-Gómez, Sandra N. Jiménez-García, Vicente Beltrán Campos, Esmeralda Rodríguez Miranda, Gabriel Herrera Pérez and Rafael Vargas-Bernal

66

Open access peer-reviewed

9. The Pragmatic Strategy to Detect Endocrine-Disrupting Activity of Xenobiotics in Food

By Shui-Yuan Lu, Pinpin Lin, Wei-Ren Tsai and Chen-Yi Weng

77

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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