Maxillomandibular advancement (MMA) using a standardized surgical procedure consisting of a LeFort I osteotomy and bilateral sagittal split ramus osteotomy and genioglossus advancement (GA) using a genioplasty improve airway volume, oxygen desaturation, and the AHI in patients with OSA. However, there are few reports on changes in sleep quality following MMA and GA. We assessed the effects of MMA and GA on sleep quality by comparing oxygen desaturation, AHI, and sleep architecture before and after surgery. Methods: Eight patients underwent polysomnography (PSG) and CT scan before and after surgery. Conclusions: Our study finds that %TST and %REM were both increased, while %S1 and NA both decreased. Based on these results, it appears that both the quality and quantity of sleep were improved. MMA and GA improve sleep respiratory disturbance and can also improve sleep quality.
- maxillomandibular advancement
- sleep quality
- respiratory disturbance
Obstructive sleep apnea (OSA) is a disorder characterized by intermittent and recurrent episodes of partial or complete upper airway obstruction during sleep. Obesity, a narrow nasopharynx and oropharynx, large soft palate, large tonsils, large tongue, tongue retroposition, micrognathia, mandibular retrognathia, and maxillary retrusion can all cause upper airway obstruction [1, 2, 3, 4, 5, 6, 7, 8].
Maxillomandibular advancement (MMA) and genioglossus advancement (GA) improve airway volume, oxygen desaturation, and the apnea-hypopnea index (AHI) in patients with OSA. However, there are few reports on changes in sleep quality and architecture following MMA and GA . Therefore, we assessed the effects of MMA and GA on sleep quality by comparing oxygen desaturation, AHI, and sleep architecture before and after MMA and GA.
2. Materials and methods
Nine OSA patients who had MMA and GA underwent polysomnography (PSG) before and after surgery, which was assessed using the same scoring criteria. One subject was excluded because computed tomography (CT) data were not collected, neither before nor after surgery. Our study included a total of eight subjects (six males and two females). The average age and body mass index (BMI) of the participants were 43.75 ± 8.17 years and 21.8 ± 1.8 kg/m2, respectively.
2.1 Surgical procedure
All patients underwent MMA using a standardized surgical procedure consisting of a LeFort I osteotomy and bilateral sagittal split ramus osteotomy and GA using a genioplasty to pull the genioglossus and geniohyoid muscles. The amount of maxillary advancement was routinely set at a minimum of 5 mm or more in consideration for unavoidable change in facial appearance. The mandibular jaw was advanced to match the maxilla, to restore the preoperative jaw relationship. The average amount of mandibular advancement was 13.2 mm. The average amount of skeletal advancement in GA was 6.3 mm. All patients were informed regarding the study protocol and provided consent.
2.2 Morphological evaluation
The lateral cephalometric radiograph were taken and calculated with manual hand-tracing.
The CT evaluation (1-mm slices) was performed with the aid of an Asteion device (TSX-021B/4; Toshiba, Tokyo, Japan), before and at 1 year after surgery. For standard reproducibility the patient was placed in the supine position, with the head and neck positioned on a pillow to maintain the Frankfurt plane at right angles to the floor. CT scans were performed during inspiration at rest, without swallowing. The upper airway area was measured in three regions: the superior posterior airway space (SPAS), which is the airway region at the midpoint between the inferior tip of the soft palate (P point) and the posterior nasal spine (PNS) point, parallel to the line from the gonion point to the point at the deepest midline concavity on the mandibular alveolus between the infradentale and pogonion (B point) (GO-B line); the middle airway space (MAS), which is the airway region on the P point parallel to the GO-B line; and the inferior airway space (IAS), which is the airway region on the GO-B line  (Figures 1 and 2).
The volume between PNS and Eb was also measured (Figure 3).
All data analyses were performed using Mimics software (Materialize, Leuven, Belgium).
2.3 Physiological evaluation (polysomnography)
Polysomnographic recordings were performed before and within 1 year after surgery. We used a 16-channel PSG instrument (Alice 5; Philips Respironics, Murrysville, PA, USA) with continuous monitoring performed by a technician. The measures taken included electroencephalography (EEG), electrooculogram (EOG), electromyogram (EMG), electrocardiogram (ECG), snore, thermocouple airflow, nasal pressure, chest and abdominal movement, pulse oximetry, and body position. Polysomnographic analyses were performed according to the American Academy of Sleep Medicine guidelines. Apnea was defined as complete cessation of airflow for more than 10 seconds. Hypopnea was defined as a decrease in airflow of 90% or more from the baseline, as measured by an oronasal thermistor for at least 10 seconds, a 30% or greater reduction in respiratory airflow lasting for more than 10 seconds, or at least a 3% decrease in oxygen saturation (SpO2) from the pre-event baseline. The 3% oxygen desaturation index (ODI) represents the average number of times per hour that the blood oxygen level drops by 3% from the baseline during sleep .
Arousal was defined as a sudden change in EEG frequency. We collected data on AHI, apnea index (AI), hypopnea index (HI), 3% ODI, lowest SpO2, percentage at which SpO2 was <90% of TST (%SpO2 < 90%), total sleep time (TST), sleep efficiency (SE: TST/time in bed [TIB]), number of awakenings (NA), percentage of nonrapid eye movement sleep stage 1 (NREM1) of TST (%S1), percentage of NREM2 of TST (%S2), percentage of NREM3 of TST (%S3), percentage of rapid eye movement (REM) sleep of TST (%REM), wakefulness after sleep onset (WASO), WASO as a proportion of sleep period time (SPT) (%WASO), sleep latency, and REM latency.
All data were analyzed using the Wilcoxon t-test, with a value of p < 0.05 considered statistically significant.
3.1 Change in the airway before versus after MMA and GA
The mean anteroposterior dimension of the SPAS, MAS, and IAS increased from 9.8 ± 3.24, 7.3 ± 2.93, and 9.6 ± 2.47 to 15.7 ± 3.67 (p < 0.005), 12.6 ± 2.94 (p < 0.005), and 15.4 ± 3.73 (p < 0.005), respectively (Figure 4).
The mean cross-sectional area of the SPAS, MAS, and IAS increased from 171.3 ± 104.6, 221.3 ± 66.6, and 200.9 ± 70.2 to 317.1 ± 141.7 (p < 0.005), 335.0 ± 132.8 (p < 0.01), and 316.9 ± 140.4 (p < 0.01), respectively. The mean enlargement factor of SPAS, MAS, and IAS was 213.0 ± 70.6%, 152.1 ± 47.3%, and 160.9 ± 54.8%, respectively. The mean volume between PNS and Eb increased from 13664.2 ± 5458.6 to 18647.0 ± 8456.0 (p < 0.01). The mean volume expansion rate was 136.5 ± 30.2% (p < 0.01) (Figure 5).
3.2 Changes in PSG parameters in subjects before versus after MMA and GA
The mean AHI decreased from 28.0 ± 24.6 to 7.4 ± 6.9 events/hour (p < 0.005), the AI decreased from 19.0 ± 25.4 to 2.3 ± 2.4 (p < 0.008), the ODI decreased from 20.5 ± 19.9 to 6.5 ± 5.9 (p < 0.008), and the %SpO2 < 90% decreased from 2.1 ± 4.0 to 0.2 ± 0.4 (p < 0.02), while the mean lowest SpO2 increased from 83.3 ± 9.5% to 88.3 ± 6.4% (p < 0.02) (Figure 6).
The mean SE increased from 81.2 ± 12.8 to 86.2 ± 7.7 (p < 0.03), and %REM increased from 15.4 ± 5.7% to 19.0 ± 3.6% (p < 0.02); meanwhile, the mean %S1 and NA decreased from 27.7 ± 21.2% to 15.3 ± 7.6% (p < 0.01) and 184.7 ± 108.4 to 119.5 ± 40.7 (p < 0.008), respectively (Figure 7).
In this study, we divided airway space into retropalatal and retroglossal spaces: SPAS and MAS corresponded to retropalatal, while IAS corresponded to retroglossal. We found an increase in anteroposterior dimension and cross-sectional area of both the retropalatal and retroglossal spaces following MMA and GA, consistent with previous studies. The volume of airway space was also increased.
The retropalatal space is influenced by the position of the maxilla, soft palate, and tonsils, while the retroglossal space is influenced by the mandibular position and glossal shape and position [11, 12, 13]. The soft palate is comprised of the musculus uvulae, tensor veli palatini, levator veli palatini, and palatoglossus. The former three muscles are attached to the maxilla, while the latter is attached to the mandible. The genioglossus and geniohyoid muscles are attached to the mental spine and hyoid bone . Airway enlargement is primarily caused by elevation of the tissues attached to the jaw and hyoid bone. Therefore, the most effective surgical approach to resolve this issue is to move both the upper and lower jaw.
Surgical success of MMA is defined as an AHI with less than 20 events/hour or an AHI showing a greater than 50% reduction after surgery. Meanwhile, surgical cure is defined as an AHI with less than five events/hour following surgery .
In this study, all patients were in the surgical success category, and 50% of patients were also classified as surgical cure.
The ODI and %SpO2 < 90% both decreased, while the lowest SpO2 increased; these results are consistent with previous reports . These findings indicate that although achieving complete cure is difficult, MMA remains an effective method for treating sleep-disordered breathing. Furthermore, improvements in the lowest SpO2 and %SpO2 < 90% levels prevent the development of oxygen-desaturation-related diseases. A number of previous studies demonstrated that hypoxia-induced oxidative stress, sympathetic activation, and inflammatory responses increase the long-term risk of multiple comorbidities, including hypertension, heart attack, stroke, and diabetes [17, 18, 19, 20, 21, 22].
The sleep architecture was also altered after MMA. There is currently no consensus on how “better sleep” should be quantitatively and qualitatively defined . However, some researchers have suggested that decreased SE, TST, and percentage of slow-wave sleep (SWS) of TST (%SWS) and increased WASO are indicators of poor sleep quality [23, 24, 25]. Others believe that improved sleep quality is reflected by the increases in %REM and %SWS, based on prior CPAP treatment data . Our study did not find any decrease in WASO. However, TST and %REM were both increased, while %S1 and NA both decreased. Furthermore, there is no significant difference, but SWS tends to increase. Based on these results, it appears that both the quality and quantity of sleep were improved.
OSA interrupts the normal sleep cycle: REM sleep disappears or becomes irregular, while SWS disappears. In our study, some subjects exhibited a REM pattern similar to that of healthy subjects, while in others no therapeutic effect of MMA was observed, despite sufficient airway expansion. Given the small number of subjects in our study, it was not possible to identify factors affecting the therapeutic efficacy. However, the most common causative factors of OSA include poor upper airway anatomy (collapsibility), weak upper airway dilator muscle responsiveness, a low respiratory arousal threshold, and an unstable ventilatory control system (loop gain) [27, 28, 29, 30]. Taken together, we consider that oxygen inhalation and sleeping medication, for example, may prove therapeutic for patients with symptoms not improved by surgical intervention alone.
MMA and GA cannot provide equal effect for every patient. The airway expansion is affected by the amount of jaw movement. However, even if the airway expansion is made bigger, it does not necessarily improve the quality of sleep. So, I must further explore other factors involved in affecting sleep quality.
MMA and GA can increase the anteroposterior dimension, cross-sectional area, and volume of the retropalatal and retroglossal spaces, consistent with previous studies.
MMA and GA may be able to improve not only sleep respiratory disturbance but also improve sleep quality.
This study was supported by the Sato Fund, Nihon University School of Dentistry; a grant from the Dental Research Center, Nihon University School of Dentistry; and the Uemura Fund, Nihon University School of Dentistry.
Data herein have been previously applied to Nichidai Shigaku (in Japanese) by Ryota Nakamura.
Conflict of interest
The authors declare no conflict of interest.
This study was performed with the approval of the Ethics Committee of Nihon University School of Dentistry.
Informed consent was obtained from all individual participants included in the study.