Open access peer-reviewed Edited Volume

Macrophage Activation

Biology and Disease

Edited by Khalid Hussain Bhat

Sher-e-Kashmir University of Agriculture Science and Technology

Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.

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Macrophage ActivationBiology and DiseaseEdited by Khalid Hussain Bhat

Published: March 25th 2020

DOI: 10.5772/intechopen.79065

ISBN: 978-1-78984-645-4

Print ISBN: 978-1-78984-644-7

eBook (PDF) ISBN: 978-1-78985-574-6

Copyright year: 2020

Books open for chapter submissions

3844 Total Chapter Downloads

8 Crossref Citations

3 Web of Science Citations

15 Dimensions Citations


Open access peer-reviewed

1. Macrophages: The Potent Immunoregulatory Innate Immune Cells

By Vijay Kumar


Open access peer-reviewed

2. The Pivotal Role of Macrophages in Metabolic Distress

By Joseph Roberts, Padraic G. Fallon and Emily Hams


Open access peer-reviewed

3. Wnt Signaling Regulates Macrophage Mediated Immune Response to Pathogens

By Suborno Jati and Malini Sen


Open access peer-reviewed

4. Macrophages in the Pathogenesis of Leprosy

By Rhana Berto da Silva Prata, Mayara Garcia de Mattos Barbosa, Bruno Jorge de Andrade Silva, Jéssica Araujo da Paixão de Oliveira, Tamiris Lameira Bittencourt and Roberta Olmo Pinheiro


Open access peer-reviewed

5. Macrophage Polarization Is Decisive for Chronic Bacterial Infection-Induced Carcinogenesis

By Mishi Wasson, Sonia Kapoor, Manoj Garg, Sandhya Singh and Hridayesh Prakash


Open access peer-reviewed

6. Polarization of Tumor-Associated Macrophages by Chinese Medicine Intervention: Mechanisms and Applications

By Yuanjun Lu, Hor Yue Tan, Ning Wang and Yibin Feng


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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