Open access peer-reviewed Edited Volume

Lipid Peroxidation Research

Edited by Mahmoud Ahmed Mansour

King Saud bin Abdulaziz University for Health Sciences

Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases.

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Lipid Peroxidation ResearchEdited by Mahmoud Ahmed Mansour

Published: January 22nd 2020

DOI: 10.5772/intechopen.73713

ISBN: 978-1-83968-548-4

Print ISBN: 978-1-83968-547-7

eBook (PDF) ISBN: 978-1-83968-549-1

Copyright year: 2020

Books open for chapter submissions

1664 Total Chapter Downloads

3 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Free Radicals and Lipid Peroxidation

By Mahmoud Ahmed Mansour

47

Open access peer-reviewed

2. Role of Lipid Peroxidation Process in Neurodegenerative Disorders

By Arunachalam Muthuraman, Narahari Rishitha, Nallupillai Paramakrishnan, Bhaskaran Mahendran and Muthusamy Ramesh

157

Open access peer-reviewed

3. Lipid Peroxidation in Meat and Meat Products

By Ana Lúcia F. Pereira and Virgínia Kelly G. Abreu

366

Open access peer-reviewed

4. Antioxidants from Nigerian Medicinal Plants: What Are the Evidence?

By Abubakar Babando Aliyu, Jonathan Ilemona Achika, Joseph Adesina Adewuyi, Patience Gangas, Hamisu Ibrahim and Adebayo Ojo Oyewale

426

Open access peer-reviewed

5. Royal Jelly and Human Interferon-Alpha (HuIFN-αN3) Affect Proliferation, Glutathione Level, and Lipid Peroxidation in Human Colorectal Adenocarcinoma Cells In Vitro

By Bratko Filipič, Lidija Gradišnik, Klemen Rihar, Adriana Pereyra, Damir Đermić and Hrvoje Mazija

133

Open access peer-reviewed

6. Statins Alone or in Combination with Ezetimibe or PCSK9 Inhibitors in Atherosclerotic Cardiovascular Disease Protection

By Marija Vavlukis and Ana Vavlukis

469

Open access peer-reviewed

7. Designating Vulnerability of Atherosclerotic Plaques

By Bukem Tanoren Bilen

68

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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