Open access peer-reviewed Edited volume

Huntington's Disease

Molecular Pathogenesis and Current Models

Edited by Nagehan Ersoy Tunalı

Istanbul Medeniyet University

Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD.

Read more >Order hardcopy
IntechOpen
Huntington's DiseaseMolecular Pathogenesis and Current ModelsEdited by Nagehan Ersoy Tunalı

Published: March 22nd 2017

DOI: 10.5772/62999

ISBN: 978-953-51-3050-5

Print ISBN: 978-953-51-3049-9

Books open for chapter submissions

2727 Total Chapter Downloads

2 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Genetic Modifiers of CAG.CTG Repeat Instability in Huntington's Disease Mouse Models

By Elodie Dandelot and Stéphanie Tomé

509

Open access peer-reviewed

2. NR1 Receptor Gene Variation is a Modifier of Age at Onset in Turkish Huntington’s Disease Patients

By Aysun Açar Hazer and Nagehan Ersoy Tunalı

472

Open access peer-reviewed

3. Pathogenesis of Huntington’s Disease: How to Fight Excitotoxicity and Transcriptional Dysregulation

By Marta Anglada-Huguet, Laura Vidal-Sancho, Nuria Cabezas-Llobet, Jordi Alberch and Xavier Xifró

472

Open access peer-reviewed

4. Porcine Model of Huntington's Disease

By Petra Rausova, Petra Vochozkova, Daniela Vidinska, Eva Hrnciarova, Bozena Bohuslavova, Monika Macakova, Ivona Valekova, Stefan Juhas, Taras Ardan, Petr Solc, Jan Motlik and Zdenka Ellederova

501

Open access peer-reviewed

5. Pluripotent Stem Cells to Model and Treat Huntington’s Disease

By Cristiane Valverde Wenceslau, Irina Kerkis, Celine Pompeia and Monica Santoro Haddad

446

Open access peer-reviewed

6. Transplantation in HD: Are We Transplanting the Right Cells?

By Sophie V. Precious and Claire M. Kelly

327

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited volume

Free shipping with DHL Express

Hardcover (ex. VAT)£140

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase