Open access peer-reviewed Edited Volume

Hepatocellular Carcinoma

Basic Research

Edited by Joseph W.Y. Lau

Chinese University of Hong Kong, China

Hepatocellular Carcinoma represents a leading cause of cancer death and a major health problem in developing countries where hepatitis B infection is prevalent. It has also become increasingly important with the increase in hepatitis C infection in developed countries. Knowledge of hepatocellular carcinoma has progressed rapidly. This book is a compendium of papers written by experts to present the most up-to-date knowledge on hepatocellular carcinoma. This book deals mainly with the basic research aspect of hepatocellular carcinoma. The book is divided into three sections: (I) Biomarkers / Therapeutic Target; (II) Carcinogenesis / Invasion / Metastasis; and (III) Detection / Prevention / Prevalence. There are 18 chapters in this book. This book is an important contribution to the basic research of hepatocellular carcinoma. The intended readers of this book are scientists and clinicians who are interested in research on hepatocellular carcinoma. Epidemiologists, pathologists, hospital administrators and drug manufacturers will also find this book useful.

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Hepatocellular CarcinomaBasic ResearchEdited by Joseph W.Y. Lau

Published: February 10th 2012

DOI: 10.5772/1205

ISBN: 978-953-51-0023-2

eBook (PDF) ISBN: 978-953-51-6804-1

Copyright year: 2012

Books open for chapter submissions

34035 Total Chapter Downloads

8 Crossref Citations

16 Web of Science Citations

27 Dimensions Citations


Open access peer-reviewed

1. LAPTM4B: A Novel Diagnostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

By Rou Li Zhou


Open access peer-reviewed

2. Novel Therapeutic Targets for Hepatocellular Carcinoma Treatment

By Yangchao Chen and Chi Han Li


Open access peer-reviewed

3. Clinical Significance of Serum Ornithine Carbamoyltransferase in Liver Diseases – Is the Ratio of OCT/ALT a New Tumor Marker?

By Katsutoshi Tokushige, Etsuko Hashimoto, Noriko Matsushita, Nobuyuki Torii, Makiko Taniai, Keiko Shiratori and Hiroshi Maruyama


Open access peer-reviewed

4. New Molecular Biomarkers Candidates for the Development of Multiparametric Platforms for Hepatocellular Carcinoma Diagnosis, Prognosis and Personalised Therapy

By Annalucia Serafino and Pasquale Pierimarchi


Open access peer-reviewed

5. Modulation of Cell Proliferation Pathways by the Hepatitis B Virus X Protein: A Potential Contributor to the Development of Hepatocellular Carcinoma

By Jessica C. Casciano, Sumedha Bagga, Bei Yang and Michael J. Bouchard


Open access peer-reviewed

6. Vascular Adhesion Protein-1 and Hepatocellular Cancer

By Ozgur Kemik, Ahu Sarbay Kemik and A. Cumhur Dulger


Open access peer-reviewed

7. Tissue Factor Pathway Inhibitor-2 Inhibits the Growth and Invasion of Hepatocellular Carcinoma Cells and is Inactivated in Human Hepatocellular Carcinoma

By Yong Xu, Xiaolin Qin, Jinjing Zhou, Zhiguang Tu, Xiao Bi, Wuxian Li, Xiaoqing Fan and Yi Zhang


Open access peer-reviewed

8. Proteoglycans in Chronic Liver Disease and Hepatocellular Carcinoma: An Update

By Péter Tátrai and Ilona Kovalszky


Open access peer-reviewed

9. Chemically Induced Hepatocellular Carcinoma and Stages of Development with Biochemical and Genetic Modulation: A Special Reference to Insulin-Like-Growth Factor II and Raf Gene Signaling

By Biswajit Mukherjee, Miltu Kumar Ghosh and Chowdhury Mobaswar Hossain


Open access peer-reviewed

10. Hepatocellular Carcinoma: Insights from the Centrosome Abnormalities

By Ying Chen and Qingzhong Kong


Open access peer-reviewed

11. Cytoplasmic Connexin32 and Self-Renewal of Cancer Stem Cells: Implication in Metastasis

By Yasufumi Omori, Yohei Kawasaki, Qingchang Li, Toshiaki Yoshioka, Yohei Yamamoto and Katsuhiko Enomoto


Open access peer-reviewed

12. The Involvement of the ERK-Hypoxia-Angiogenesis Signaling Axis and HIF-1 in Hepatocellular Carcinoma

By Ilias Mylonis and George Simos


Open access peer-reviewed

13. Gap Junction Intercellular Communication and Connexin Expression Profile in Normal Liver Cells and Hepatocarcinoma

By Glaucia M. Machado-Santelli and Marisa Ionta


Open access peer-reviewed

14. Mechanisms of HBx Mediated Liver Cancer: Multiple Pathways and Opportunities

By Mark A. Feitelson, Alla Arzumanyan, Tiffany Friedman, N. Lale Tufan, Zhaorui Lian, Marcia M. Clayton, Joyce Kang, Helena M. G. P. V. Reis, Jingbo Pan, Jie Liu, Patrick Arbuthnot and Michael Kew,


Open access peer-reviewed

15. Molecular Mechanism of DNA Damage Response Pathway During Hepatic Carcinogenesis

By Yasunobu Matsuda and Toshifumi Wakai


Open access peer-reviewed

16. Hepatocellular Carcinoma: Methods of Circulating Tumor Cells (CTC) Measurements

By Natalia Olaya and Franck Chiappini


Open access peer-reviewed

17. Use of a Human–Derived Liver Cell Line for the Detection of Protective Effect of Dietary Antioxidants against Food Mutagens

By Paloma Morales and A.I. Haza


Open access peer-reviewed

18. Reviews on the Epidemiology, Quality of Life, and Management of Chronic Hepatitis B (CHB)

By Elegance T.P. Lam and Cindy L.K. Lam


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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