Open access peer-reviewed Edited Volume

Hepatocellular Carcinoma

Advances in Diagnosis and Treatment

Edited by Costin Teodor Streba

University of Medicine and Pharmacy of Craiova


Cristin Constantin Vere

University of Medicine and Pharmacy of Craiova

Ion Rogoveanu

University of Medicine and Pharmacy of Craiova

Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.

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Hepatocellular CarcinomaAdvances in Diagnosis and TreatmentEdited by Costin Teodor Streba

Published: November 28th 2018

DOI: 10.5772/intechopen.69753

ISBN: 978-1-78984-274-6

Print ISBN: 978-1-78984-273-9

eBook (PDF) ISBN: 978-1-83881-415-1

Copyright year: 2018

Books open for chapter submissions

5001 Total Chapter Downloads

1 Crossref Citations

1 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Etiology and Pathogenesis of Hepatocellular Carcinoma

By Costin Teodor Streba, Cristin Constantin Vere, Ion Rogoveanu and Nicu Dan Florescu


Open access peer-reviewed

2. Diagnostic Algorithm of Hepatocellular Carcinoma: Classics and Innovations in Radiology and Pathology

By Dzeina Mezale, Ilze Strumfa, Andrejs Vanags, Arturs Kalva, Dainis Balodis, Boriss Strumfs, Ilze Fridrihsone, Arnis Abolins and Janis Gardovskis


Open access peer-reviewed

3. Innovative Blood Tests for Hepatocellular Carcinoma: Liquid Biopsy and Evaluation of Systemic Inflammatory Reaction

By Ilze Strumfa, Dzeina Mezale, Boriss Strumfs, Andrejs Vanags, Arturs Kalva, Dainis Balodis, Ilze Fridrihsone, Arnis Abolins and Janis Gardovskis


Open access peer-reviewed

4. Cellular Senescence and Their Role in Liver Metabolism in Health and Disease: Overview and Future Directions

By Matthew Schade, Jacqueline A Sanabria, Milad Modarresi, Bryan Gillon, Zach Hunter, Jacqueline Fannin, Amrita Mallick, Henri Brunengraber and Juan Sanabria


Open access peer-reviewed

5. The Diagnostic and Prognostic Potential of MicroRNAs for Hepatocellular Carcinoma

By Xi-Dai Long, Wei-Zhong Tang, Jun Lu, Xiao-Ying Huang, Jin-Guang Yao, Tian-Qi Zhang, Xing-Zhizi Wang, Qun-Ying Su, Chun-Ying Luo, Xue-Ming Wu, Chao Wang, Li-Xia Zeng, Qiang Xia and Yun Ma


Open access peer-reviewed

6. Oncogenic Secretory Clusterin: A Promising Therapeutic Target for Hepatocellular Carcinoma

By Min Yao, Wenjie Zheng, Li Wang, Miao Fang, Dengfu Yao and Zhizheng Dong


Open access peer-reviewed

7. Minimally Invasive Therapies for Hepatocellular Carcinoma: Mechanisms of Local Control and Systemic Immunologic Response

By Andrew W. Ritchey, Joshua D. Kuban and Rahul A. Sheth


Open access peer-reviewed

8. Emerging Targeted Therapies for Treatment of Hepatocellular Carcinoma (HCC)

By Sarwat Fatima, Nikki Pui-Yue Lee, Hiu Yee Kwan and Zhao Xiang Bian


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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