Open access

Regulation and Differential Secretion of Gonadotropins During Post Partum Recovery of Reproductive Function in Beef and Dairy Cows

Written By

Mark A. Crowe and Michael P. Mullen

Submitted: 11 December 2011 Published: 20 February 2013

DOI: 10.5772/48654

From the Edited Volume

Gonadotropin

Edited by Jorge Vizcarra

Chapter metrics overview

3,007 Chapter Downloads

View Full Metrics

1. Introduction

Reproductive efficiency in dairy and beef cows is dependent on achieving high submission rates and high conception rates per service. However, to achieve good submission and conception rates cows must resume ovarian cyclicity, have normal uterine involution, be detected in estrus, and inseminated at an optimum time. In seasonally calving herds the aim is to achieve conception by 85 days following parturition so that calving to calving intervals are maintained at 365 days. Reproductive performance of cows affects the efficiency of milk production in the herd because of its influence on the calving to first service interval, calving pattern, length of lactation and culling rate.

The pattern of resumption of ovarian function in both dairy and beef cows was recently reviewed (Crowe 2008). Resumption of ovarian cyclicity is largely dependent on LH pulse frequency. Both dairy and beef cows have early resumption of follicular growth within 7 to 10 days post partum. The fate of the dominant follicle within the first follicular wave is dependent on LH pulsatility. This chapter will focus on the factors contributing to resumption of ovulation in postpartum dairy and beef cows.

Advertisement

2. Ovarian follicle growth in cattle

Ovarian follicle growth takes a period of 3-4 months and can be categorized into gonadotropin independent and gonadotropin dependent stages (Webb et al. 2004). Gonadotropin dependent follicle growth in cattle occurs in waves (Rajakoski 1960; Matton et al. 1981; Ireland and Roche 1987; Savio et al. 1988; Sirois and Fortune 1988). Each wave of growth involves emergence, selection and dominance followed by either atresia or ovulation. Emergence of a follicle wave is defined as growth of a cohort of follicles ≥ 5mm in diameter and coincides with a transient increase in FSH secretion (Adams et al. 1992; Sunderland et al. 1994). Selection is the process by which the growing cohort of follicles is reduced to the ovulatory quota for the species (in cattle it is generally one), selection occurs in the face of declining FSH concentrations (Sunderland et al. 1994). The selected follicle survives in an environment of reduced FSH due to the development of LH receptors in granulosa cells (Xu et al. 1995, Bao et al. 1997) and increased intrafollicular bioavailable insulin-like growth factor-I (IGF-I; Austin et al. 2001; Canty et al. 2006). The increased bioavailable IGF-I is achieved by reduced IGF-I binding proteins (IGFBP) due to increased IGFBP protease activity. Dominance is the phase during which the single selected follicle actively suppresses FSH concentrations and ensures suppression of all other follicle growth on the ovaries (Sunderland et al. 1994). The fate of the dominant follicle is then dependent on the prevailing LH pulse frequency during the dominance phase. In the presence of elevated progesterone (luteal phase of cyclic animals) LH pulse frequency is maintained at 1 pulse every 4 hours and the dominant follicle undergoes atresia, in the follicular phase (preovulatory period in cyclic animals) the LH pulse frequency increases to one pulse per hour and this stimulates final maturation, increased estradiol concentrations and positive feedback on gonadotropin-releasing hormone (GnRH), LH (and FSH) in a surge that induces ovulation (Sunderland et al. 1994). Normal follicle waves have an inherent lifespan of 7 to 10 days in duration from the time of emergence of a wave until emergence of the next wave (indicating either ovulation or physiological atresia of the dominant follicle). In cyclic heifers during the normal 21 day estrous cycle there are normally 3 waves (sometimes 2 waves and rarely 1 or 4 waves; Savio et al. 1988; Murphy et al. 1991).

2.1. Pattern of gonadotropin secretion and follicle growth during pregnancy

During pregnancy follicular growth continues during the first two trimesters (Ginther et al. 1989; Ginther et al. 1996) at regular 7 to 10 day intervals. In late pregnancy (last 22 days) the strong negative feedback of progestagens (mostly from the CL of pregnancy and partly of placental origin) and estrogens (mostly placental in origin) suppresses the recurrent transient FSH rises that stimulate follicle growth (Ginther et al. 1996; Crowe et al. 1998; Figure 1) so that the ovaries during the last 20 – 25 days are largely quiescent.

2.2. Resumption of gonadotropin secretion and follicle growth post partum

At the time of parturition progesterone and estradiol concentrations cascade to basal concentrations. This allows for the almost immediate resumption of recurrent transient increases in FSH concentrations (within 3 to 5 days of parturition) that occur at 7 to 10 day intervals (Crowe et al. 1998). The first of these increases stimulates the first postpartum wave of follicle growth that generally produces a dominant follicle by 7-10 days post partum (Savio et al. 1990a; Murphy et al. 1990; Crowe et al. 1993). The fate of this first follicular wave dominant follicle is dependent on its ability to secrete sufficient estradiol to induce a gonadotropin surge. The capacity for estradiol secretion is in turn dependent on the prevailing LH pulse frequency during the dominance phase of the follicle wave, the size of the dominant follicle and IGF-I bioavailability (Austin et al. 2001; Canty et al. 2006). So the major driver for ovulation of a dominant follicle during the postpartum period is the LH pulse frequency. This has been tested and validated by the LH pulsatile infusion studies of Duffy et al. (2000) in early postpartum anestrous beef cows. The LH pulse frequency required to stimulate a dominant follicle towards ovulation is one LH pulse per hour. Figure 2 is a schematic indicating the likely fate of the early postpartum dominant follicles in beef and dairy cows. In beef cows the first dominant follicle generally does not ovulate (Murphy et al. 1990, Stagg et al. 1995), but rather it undergoes atresia. With beef cows in good body condition the first postpartum dominant follicle to ovulate is generally from wave 3.2 ± 0.2 (~ 30 days; Murphy et al. 1990); whereas for beef cows in poor body condition there are typically 10.6 ± 1.2 waves of follicular growth before ovulation occurs (~ 70-100 days; Stagg et al. 1995; Figure 3). In the case of dairy cows ovulation of the first postpartum dominant follicle typically occurs in 50 to 80% of cows, it undergoes atresia in 15 to 60% of cows or becomes cystic in 1-5% of cows (Savio et al. 1990b; Beam and Butler 1997; Sartori et al. 2004; Sakaguchi et al. 2004).

Figure 1.

Follicle-stimulating hormone (FSH), progesterone (P4), estradiol (E2) and follicular diameter profiles in two representative beef cows from ~30 days prepartum until 50 days postpartum (Crowe et al. 1998).

Figure 2.

Diagrammatic scheme of resumption of dominant follicles and ovarian cycles during the postpartum period in dairy and beef suckler cows not nutritionally stressed. LH pulse frequency is that occurring during an 8 h window where cows are blood sampled every 15 min. Short cycles occur in most (70%), but not all cows after first ovulation (Reprinted with permission Crowe, 2008).

First ovulation in both dairy and beef cows is generally silent (i.e., no behavioural estrus; Kyle et al. 1992) and is generally (>70%) followed by a short cycle, usually containing just one follicle wave. This first luteal phase is reduced in length due to the premature release of prostaglandin F2α (PGF2α; Peter et al. 1989) presumably arising from the increased estradiol produced from the formation of the post-ovulatory dominant follicle on days 5-8 of the cycle inducing premature estradiol and oxytocin (Zollers et al., 1993) receptors. Thus the corpus luteum regresses prematurely around days 8-10 of the cycle, with the second ovulation (of this post-ovulatory dominant follicle) occurring around days 9-11 after the first ovulation. This second ovulation is generally associated with the expression of estrus and a normal length luteal phase.

Cyclic postpartum cows may have 2, 3 or occasionally 4 follicle waves during the estrous cycles that occur in the postpartum period (Savio et al. 1990a; Sartori et al. 2004). Unlike non-lactating heifers, lactating Holstein postpartum dairy cows tend to have two follicle waves per 18-23 day cycle (Sartori et al. 2004). Progesterone concentration is the major factor that affects LH pulse frequency in cyclic animals. Generally lactating Holstein dairy cows tend to have lower progesterone concentrations during the cycle than cyclic heifers (Sartori et al. 2004; Wolfenson et al. 2004). These lower progesterone concentrations tend to allow a subtle increase in LH pulse frequency and allows for prolonged growth of each dominant follicle rather than the faster atresia that occurs in cyclic heifers. Cows with prolonged luteal phases tend to have a fourth follicle wave (Savio et al. 1990a). The number of follicle waves or rate of turnover of dominant follicles are directly related to the duration of dominance of each dominant follicle, and cattle with shorter durations of dominance for the ovulatory dominant follicles tend to have higher conception rates (Austin et al. 1999). Therefore nutrition, by altering metabolic clearance of progesterone can affect the duration of dominance of a dominant follicle, the number of follicle waves per cycle and have an indirect effect on conception rates.

Figure 3.

Pattern of growth and regression of dominant follicles from calving to second ovulation in (a) a beef suckler cow with two non-ovulatory follicle waves prior to first ovulation, and (b) a beef suckler cow with 14 non-ovulatory waves prior to first ovulation. Arrows indicate ovulation. Reproduced with permission Stagg et al. (1995); Crowe 2008.

Advertisement

3. Post-partum anestrus

3.1. Factors contributing to LH pulse frequency in early post-partum beef cows

The major factors that control LH pulse frequency (and therefore the fate of early postpartum dominant follicles) in postpartum beef cows include maternal bond / calf presence (presumably due to effects on opioid release), suckling inhibition (Myers et al. 1989), and poor body condition (Canfield and Butler 1990). Calf presence has a very clear negative effect on resumption of ovulation in beef suckler cows nursing calves. Restricted suckling of beef cows (once per day) from day 30, where calves were in an isolated pen away from sight of the cows, significantly advanced the interval from calving to first ovulation (51 days) compared with ad libitum suckled control cows (79 days). The effect of calf presence can be further compartmentalized into suckling stimuli (mammary sensory pathways) and maternal behaviour / bonding effects (Silveira et al. 1993; Williams et al. 1993) but requires positive calf identification by either sight or olfaction (Griffith and Williams 1996). Beef cows that calve down in poor BCS (<2.5; scale 1-5 as described by Lowman et al. 1976) are more likely to have a prolonged anestrous period (Stagg et al. 1995) due presumably to lower LH pulse frequency (Stagg et al. 1998). Similarly anestrus can be induced by chronic nutrition restriction in post-partum beef cows, and occurs when cows lose 22-24% of their initial body weight (Richards et al, 1989).

As beef suckler cows (with prolonged anovulatory anestrus) approach their first postpartum ovulation LH pulse frequency increases (observed during each sequential follicle wave from 6 waves before ovulation until the ovulatory wave; Stagg et al. 1998). Concentrations of IGF-I increased linearly from 75 days before first ovulation until ovulation which was associated with a linear decrease in growth hormone concentrations during the same period (Stagg et al. 1998). Thus postpartum beef cows require increased LH pulse frequency that is mediated largely by suckling inhibition and plane of nutrition, in addition to increased IGF-I concentrations to help stimulate dominant follicle maturation and growth so that there is sufficient secretion of estradiol to induce an LH surge and ovulation. Management may be used to encourage earlier ovulation by restricting suckling / access of the cows to the calves from approximately day 30 post partum (Stagg et al. 1988) or by increased plane of nutrition and body condition.

3.2. Factors contributing to LH pulse frequency in early postpartum dairy cows

In dairy cows the major factors affecting resumption of ovulation include BCS and energy balance (yield and dry matter intake), parity, season and disease (Bulman and Lamming 1978; Beam and Butler 1997; Beam and Butler 1999; Opsomer et al. 2000; Wathes et al. 2007). Energy intake, BCS and milk yield interact to affect energy balance in dairy cows. There is evidence to link many of these factors to reduced LH pulse frequency; indeed a negative association between energy balance and prolonged post-partum anestrous interval is well established for dairy cows (Butler et al. 1981; Canfield and Butler 1990; Staples et al. 1990) and is mediated by reduced LH pulse frequency (Canfield and Butler, 1990). A number of studies have been conducted in dairy cows of various yield potential that have categorised the pattern of resumption of ovarian function with the use of milk progesterone. These range from a study by Fagan and Roche (1986) using what would now be classified as traditional moderate yielding Friesian cows (4,000 – 5,000 kg milk per lactation) to that of Opsomer et al. (1998) using modern high yielding Holstein type cows (6,900 – 9,800 kg milk per lactation). The data from these two studies are summarised in Table 1. Furthermore, this pattern of resumption of ovarian function has been validated in a series of equivalent papers and the two key problem categories (prolonged interval to first ovulation and prolonged luteal phase) are summarized in Figure 4. Risk factors for these two ovarian abnormalities have been determined in a large epidemiological study by Opsomer et al. (2000). The major risk factors for a prolonged interval to first ovulation included (odds ratio in parentheses): acute body condition score loss up to 60 days post calving (18.7 within 30 days, 10.9 within 60 days), clinical ketosis (11.3), clinical diseases (5.4), abnormal vaginal discharge (4.5), and difficult calving (3.6).

Figure 4.

Percentage of cows defined as having either i) delayed resumption of ovulation or ii) prolonged luteal phases based on evaluation of milk progesterone profiles across a number of studies in dairy cows (compiled by Benedicte Grimard, France, personal communication; Reproduced with permission, Crowe 2008).

The greatest of these risk factors is acute body condition score loss. Current evidence suggests that dairy cows should calve down in a BCS of 2.75 – 3.0 (Scale 1-5; as described by Edmonson et al. 1989) and not lose more than 0.5 of a BCS unit between calving and first service (Overton and Waldron 2004; Mulligan et al. 2006) rather than earlier recommendations of 3.0 – 3.5 (Buckley et al. 2003). Cows that lose excessive body condition (≥ 1.0 BCS unit) have a longer postpartum interval to first ovulation. Thus monitoring BCS from before calving to first service is essential to good reproductive management. Body condition score changes are good indicators of energy balance and reflect milk yield and dry matter intake. It is necessary to prevent a steep decline in energy balance and shorten the duration of postpartum negative energy balance. This is best achieved by ensuring that dry matter intake in the early postpartum period is maximized and by having cows in appropriate BCS (2.73 – 3.0) at calving. Cows that are mobilizing tissue at a high rate have increased blood non-esterified fatty acids, and β-hydroxy butyrate, but reduced concentrations of insulin, glucose and IGF-I (Grummer et al. 2004). The metabolic status associated with high rates of tissue mobilization increases the risk of hypocalcaemia, acidosis, fatty liver, ketosis and displaced abomasa (Gröhn and Rajala-Schultz 2001; Overton and Waldron 2004, Maizon et al. 2004). Cows affected by these metabolic disorders are more prone to anestrus, mastitis, lameness and reduced conception rate to AI (Fourichon et al. 1999; Gröhn and Rajala-Schultz 2001; Lucy 2001; Lopez-Gatius et al. 2002; Maizon et al. 2004). It is hypothesized that serum IGF-I concentrations could be useful as a predictor of nutritional status and hence reproductive efficiency in dairy cows (Zulu et al. 2002a). Plasma IGF-I concentrations before calving and in the first few weeks of lactation have been linked to subsequent cyclicity and conception rate (Taylor et al. 2006). This emphasizes the critical role of correct nutritional management to ensure that the deficit in energy balance post calving is mild rather than severe. Current approaches to minimize the energy balance deficit post calving includes: the optimization of body condition score at calving (2.75 - 3.0), shorter dry periods and maintenance of normal rumen function (Mulligan et al. 2006).

ItemFagan and Roche 1986
Moderate yielding Friesian cows
Opsomer et al. 1998
High yielding Holstein cows
No. of cows / postpartum periods463448
Normal cyclic patterns (%)7853.5*
Prolonged interval to 1st ovulation (%)720.5*
Prolonged luteal phase (%)320*
Temporary cessation of ovulation (%)33
Short cycles (%)40.5
Other irregular patterns (%)42.5

Table 1.

Pattern of resumption of ovarian cyclicity in postpartum dairy cows (traditional moderate yielding Friesians vs modern high yielding Holsteins), using milk progesterone profiling (samples collected twice weekly). *Categories with a major disparity between the two studies.

Disease state may also regulate follicle fate via LH and other mechanisms. Uterine conditions such as retained foetal membranes, endometritis and metritis contribute to reproductive efficiency via various mechanisms. Local infection of the uterus in postpartum cows delays uterine involution, causes inflammation of the endometrium, reduce conception rate to first insemination (Sheldon 2004), but may also affect follicle growth, decrease estradiol secretion from dominant follicles, and delay the interval to first ovulation (LeBlanc et al. 2002; Sheldon et al. 2002; Sheldon and Dobson 2004; Williams et al. 2007; Sheldon et al. 2008). These effects on follicle growth and ovulation implicate potential roles mediated by either direct effects within follicles and reduced LH secretion / failure of the gonadotropin surge. Indeed the evidence supports both possible mechanisms: uterine disease associated with E. Coli or infusion of endotoxins reduces estradiol secretion from dominant follicles (Sheldon et al. 2002; Herath et al. 2007) and delays the LH surge and ovulation (Suzuki et al. 2001). Other diseases such as mastitis (Huzenicza et al. 2005) and lameness (Petersson et al. 2006) delay resumption of luteal activity by 7 to 17 days, respectively. For these there is considerable evidence that this is mediated due to acute stressors reducing GnRH and hence LH pulse frequency, leading to decreased estradiol production by dominant follicles and preventing or reducing the gonadotropin surge, thus delaying ovulation.

Advertisement

4. Abnormal ovarian function during the post-partum period

4.1. Prolonged luteal phases

Irregular estrous cycles in cows once they have resumed ovulation tend to be predominantly prolonged luteal phases. The incidence of prolonged luteal phases has increased from 3% (Fagan and Roche 1986) to 11-22% (Lamming and Darwash 1998; Opsomer et al. 1998; Shrestra et al. 2004; Figure 4). It is generally considered that prolonged luteal phases are associated with an abnormal uterine environment that disrupts prostaglandin production. Interestingly in the study of Opsomer et al. (1998), where the incidence of cows with prolonged luteal phases was 20% (89/448 cows), only 43/89 cows had abnormal uterine content, 2/89 had ovarian cysts and 44/89 had no detectable abnormalities. However in this study abnormalities were identified only by rectal palpation. The major risk factors for a prolonged luteal phase in cows having resumed ovulation included (odds ratio in parentheses; Opsomer et al. 2000): metritis (11.0), abnormal vaginal discharge (4.4), retained placenta (3.5), parity (2.5 for parity 4+ vs primiparous), earlier resumption of ovulation (2.8 for resumption < 19 days post partum, 2.4 for resumption 19-24 days post partum). These data support the concept that prolonged luteal phases are related to uterine problems rather than ovarian problems.

4.2. Follicular cysts

These occur where dominant follicles in the early postpartum period (often the first dominant follicle postpartum) fail to ovulate. Cysts typically continue to grow to diameters >20-25 mm over a 10 to 40 day period in the absence of a CL (Savio et al. 1990a; Gümen et al. 2002, Hatler et al. 2003). This continued growth appears to be due to lack of positive feedback induced by estradiol and thus failure of the LH/FSH pre-ovulatory surge, despite increased LH pulse frequency (to an intermediate level). At this time progesterone concentrations are low, while estradiol concentrations are elevated above normal pro-estrus concentrations (Savio et al. 1990b; Hatler et al. 2003), resulting in many cases in strong exhibition of estrous behaviour by cows in the early phases of a follicular cyst. This is followed by a period of time when there is an absence of estrous behaviour in the second half of the cysts lifespan. The elevated estradiol in conjunction with elevated inhibin suppresses FSH concentrations, so that no new follicle waves emerge during the early active phase of a follicular cyst. The cyst then becomes estrogen inactive (despite being morphologically still present) and a new follicle wave emerges. The dominant follicle of this new wave may either ovulate, undergo atresia or become cystic. Many cows with follicular cysts correct themselves, but some develop sequential follicular cysts. The metabolic risk factors associated with cows that develop cysts in the early postpartum period are over conditioned cows, a reduction in insulin (Vanholder et al. 2005) and IGF-I, and increased non-esterified fatty acids (Zulu et al. 2002b).

Advertisement

5. Induction of estrus and ovulation in anovulatory anestrous cows

From the previous sections it is clear that in many cases (especially with dairy cows) anovulatory anestrus is associated with management risk factors and other diseases (excessive loss of BCS, severe lameness, uterine disease, displaced abomasum, etc). Therefore before embarking on a specific treatment for anestrus, the underlying factors and diseases should be first addressed before commencement of specific treatments for the ovarian problems.

5.1. GnRH

The major cause of delayed ovulation in postpartum cows is an infrequent LH pulse frequency (and by inference GnRH pulse frequency). GnRH treatment was used with variable effectiveness in numerous studies of postpartum cows when the follicle status of the animals was unknown. A single injection, two injections 10 days apart, or frequent low dose injections at 1- to 4-h intervals of GnRH or GnRH analogues failed consistently to induce ovulation in over 90% of treated anestrous cows (Mawhinney et al. 1979; Riley et al. 1981; Walters et al. 1982; Edwards et al. 1983). However, when a GnRH analogue (20 µg Buserelin) was used at known stages of follicle growth (determined by daily ultrasound scanning) of the first postpartum DF, all cows ovulated when administered during the growing phase of the DF (12/12) and the majority (7/10) ovulated when the first postpartum DF was in its plateau / early declining phase of growth (Crowe et al. 1993). In a further study conducted by Ryan et al. (1998), 250 µg GnRH resulted in ovulation in 20 of 20 cows when given at dominance of a follicular wave, this was followed by emergence of a new wave of ovarian follicular growth 1.6 ± 0.3 days later and dominance of the subsequent wave was attained in 5 ± 0.3 days. However, there was no effect of GnRH on follicular dynamics when given at emergence of a follicular wave. The existing cohort of follicles continued to develop unaffected in 17 of 17 cows, and dominance occurred 3.6 ± 0.5 days later. Thus, GnRH may cause ovulation or no effect on follicle development depending on the animal’s stage of follicle development at treatment. Thus when GnRH is used as part of an ovsynch protocol (GnRH-PGF2α-GnRH treatment) in postpartum anestrous cows the effectiveness of the treatment is wholly dependent on the presence or absence of a DF at the time the first GnRH injection is administered.

5.2. Progesterone

Treatment of anestrous cows with progesterone (and estradiol) will induce estrus and shorten the postpartum interval to conception (Rhodes et al. 2003). Anestrous cows require progesterone treatment to ensure that the first ovulation is associated with expression of estrus and a normally functioning luteal phase. The use of eCG may accompany progesterone treatment in cows that are in deep anovulatory anestrus to ensure ovulation (Mulvehill and Sreenan 1977), but care must be taken not to induce too high an ovulation rate.

5.3. Restricted suckling (beef cows)

Earlier onset of ovulation in beef cows may be induced by restricting suckling by calves from 30 days post partum (Stagg et al. 1998). Restricted suckling involves once or twice daily access of calves to cows for suckling and at other times of the day the calves are isolated and out of sight of the cows (Stagg et al. 1998).

Advertisement

6. Conclusions

Follicular growth generally resumes within 7-10 days post partum in the majority of cows associated with a transient FSH rise that occurs within 3 to 5 days of parturition. A summary of reproductive parameters for beef and dairy cows is presented in Table 2. Delayed resumption of ovulation is invariably due to a lack of LH pulse frequency whether it is due to suckling inhibition in beef cows or metabolic related stressors in high yielding dairy cows. First ovulation in both dairy and beef cows is generally silent and followed by a short cycle. The key to optimizing resumption of ovulation in both beef and dairy cows is appropriate pre-calving nutrition and management so that cows calve down in optimal body condition (body condition score 2.75-3.0) with postpartum body condition loss restricted to <0.5 body condition score units.

Dairy cowsBeef cows
Emergence of the 1st follicle wave (days post partum)5-105-10
% cows that ovulate the 1st dominant follicle50-8020-35
Postpartum interval to first estrus (days)25-4530-130
Nature of 1st ovulationsilentsilent
% short cycles after 1st ovulation"/>70"/>70
Regulation of LH pulse frequency•declining energy balance
•BCS at calving
•dry matter intake
•suckling
•maternal bond
•declining energy balance
•BCS at calving

Table 2.

Reproductive parameters in the early postpartum period of dairy and beef suckler cows

References

  1. 1. AdamsG. P.MatteriR. L.KastelicJ. P.KoJ. C. H.GintherO. J. 1992 Association between surges in follicle-stimulating hormone and emergence of follicular waves in heifers. Journal of Reproduction and Fertility 94 177188 .
  2. 2. AustinE. J.MihmM.EvansA. C. O.KnightP. G.IrelandJ. L. H.IrelandJ. J.RocheJ. F. 2001 Alterations in intrafollicular regulatory factors and apoptosis during selection of follicles in the first follicular wave of the bovine oestrous cycle. Biology of Reproduction 64 839848 .
  3. 3. AustinE. J.MihmM.RyanM. P.WilliamsD. H.RocheJ. F. 1999 Effect of duration of dominance of the ovulatory follicle on the onset of estrus and fertility in heifers. Journal of Animal Science 77 22192226 .
  4. 4. BaoB.GarverickH. A.SmithG. W.SmithM. F.SalfenB. E.YoungquistR. S. 1997 Changes in messenger ribonucleic acid encoding luteinizing hormone receptor, cytochrome 450 chain cleavage, and aromatase are associated with recruitment and selection of bovine ovarian follicles. Biology of Reproduction 56: 1158-1168
  5. 5. BeamS. W.ButlerW. R. 1997 Energy balance and ovarian follicle development prior to the first ovulation postpartum in dairy cows receiving three levels of dietary fat. Biology of Reproduction 56 133142 .
  6. 6. BeamS. W.ButlerW. R. 1999 Effects of energy balance on follicular development and first ovulation in post-partum dairy cows. Journal of Reproduction and Fertility Supplement 411424 .
  7. 7. BuckleyF.O’SullivanK.MeeJ. F.EvansR. D.DillonP. 2003 Relationships among milk yield, body condition, cow weight, and reproduction in spring-calved Holstein-Friesians. Journal of Dairy Science 86 23082319 .
  8. 8. BulmanD. C.LammingG. E. 1978 Milk progesterone levels in relation to conception, repeat breeding and factors influencing acyclicity in dairy cows. Journal of Reproduction and Fertilty 54 447458 .
  9. 9. ButlerW. R.EverettR. W.CoppockC. E. 1981 The relationships between energy balance, milk production and ovulation in post-partum Holstein cows. Journal of Animal Science 53 742748
  10. 10. CanfieldR. W.ButlerW. R. 1990 Energy balance and pulsatile LH secretion in early postpartum dairy cattle. Domestic Animal Endocrinology 7 323330 .
  11. 11. CantyM. J.BolandM. P.EvansA. C. O.CroweM. A. 2006 Alterations in follicular IGFBP-2,-3 and-4 mRNA expression and intrafollicular IGFBP concentrations during the first follicle wave in beef heifers. Animal Reproduction Science 93 199217 .
  12. 12. CroweM. A.GouldingD.BaguisiA.BolandM. P.RocheJ. F. 1993 Induced ovulation of the first postpartum dominant follicle in beef suckler cows using a GnRH analogue. Journal of Reproduction and Fertilty99 551555 .
  13. 13. CroweM. A.PadmanabhanV.MihmM.BeitinsI. Z.RocheJ. F. 1998 Resumption of follicular waves in beef cows is not associated with periparturient changes in follicle-stimulating hormone heterogeneity despite major changes in steroid and luteinizing hormone concentrations. Biology of Reproduction 58 14451450 .
  14. 14. DuffyP.CroweM. A.BolandM. P.RocheJ. F. 2000 Effect of exogenous LH pulses on the fate of the first dominant follicle in postpartum beef cows nursing calves. Journal of Reproduction and Fertilty 118 917 .
  15. 15. EdmonsonA. J.LeanI. J.WeaverL. D.FarverT.WebsterG. 1989 A body condition scoring chart for Holstein dairy cows. Journal of Dairy Science 72 6878 .
  16. 16. EdwardsS.RocheJ. F.NiswenderG. D. 1983 Response of suckling beef cows to multiple, low-dose injections of Gn-RH with or without progesterone pretreatment. Journal of Reproduction and Fertilty69 6572 .
  17. 17. FaganJ. G.RocheJ. F. 1986 Reproductive activity in postpartum dairy cows based on progesterone concentrations in milk or rectal examination. Irish Veterinary Journal 40 124131 .
  18. 18. FourichonC.SeegersH.MalherX. 1999 Effects of disease on reproduction in the dairy cow. A meta-analysis. Theriogenology 53 17291759 .
  19. 19. GintherO. J.KnopfL.KastelicJ. P. 1989 Ovarian follicular dynamics in heifers during early pregnancy. Biology of Reproduction 41 247254 .
  20. 20. GintherO. J.KotK.KulickL. J.MartinS.WiltbankM. C. 1996 Relationship between FSH and ovarian follicular waves during the last six months of pregnancy in cattle. Journal of Reproduction and Fertilty 108 271279 .
  21. 21. GriffithM. K.WilliamsG. L. 1996 Roles of maternal vision and olfaction in suckling-mediated inhibition of luteinizing hormone secretion. Expression of maternal selectivity, and lactational performance of beef cows. Biology of Reproduction 54 761768 .
  22. 22. GrimardB.TouzeJ. L.LaigreP.ThomeretF. 2005 Abnormal patterns of resumption of ovarian postpartum cyclicity in Prim’Holstein dairy cows: risk factors ad consequences on reproductive efficiency. Reproduction in Domestic Animals (Abstract) 40: 342.
  23. 23. GröhnY. T.Rajala-SchultP. J. 2000 Epidemiology of reproductive performance in dairy cows. Animal Reproduction Science 60/61 605614 .
  24. 24. GrummerR. R.MashekD. G.HayirliA. 2004 Dry matter intake and energy balance in the transition period. Veterinary Clinics of North America: Food Animal Practice 20 447470 .
  25. 25. HerathS.WilliamsE. J.LillyS. T.GilbertR. O.DobsonH.BryantC. E.SheldonI. M. 2007 Ovarian follicular cells have innate immune capabilities that modulate their endocrine function. Reproduction 134 683693 .
  26. 26. HuszeniczaG.JanosiS.KulcsarM.KorodiP.ReiczigelJ.KataiL.PetersA. R.de RensisF. 2005 Effects of clinical mastitis on ovarian function in post-partum dairy cows. Reproduction in Domestic Animals 40 199204 .
  27. 27. IrelandJ. J.RocheJ. F. 1987 Hypothesis regarding development of dominant follicles during a bovine estrous cycle. In: Roche, J.F. and O’Callaghan, D. (eds), Follicular growth and ovulation rate in farm animals. Martinus Nijhoff The Netherlands, 118 .
  28. 28. KyleS. D.CallahanC. J.AllrichR. D. 1992 Effect of progesterone on the expression of estrus at the first postpartum ovulation in dairy cattle. Journal of Dairy Science 75 14561460 .
  29. 29. LammingG. E.DarwashA. O. 1998 The use of milk progesterone profiles to characterize components of subfertility in milked dairy cows. Animal Reproduction Science 52 175190 .
  30. 30. Le BlancS. J.DuffieldT. F.LeslieK. E.BatemanK. G.KeefeG. P.WaltonJ. S.JohnsonW. H. 2002 Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows. Journal of Dairy Science 85 22232236 .
  31. 31. López-GatiusF.SantolariaP.YánizJ.FrenchM.López-BéjarM. 2002 Risk factors for postpartum ovarian cysts and their spontaneous recovery or persistence in lactating dairy cows. Theriogenology 58 17231632 .
  32. 32. LowmanB. G.ScottN. A.SomervilleS. H. 1976 Condition scoring of cattle. Review Edition Bulletin, East of Scotland College of Agriculture, 6 Scotland.
  33. 33. LucyM. C. 2001 Reproductive loss in high-producing dairy cattle: where will it end? Journal of Dairy Science 84 12771293 .
  34. 34. MaizonD. O.OltenacuP. A.GröhnY. T.StrawdermanR. L.EmanuelsonU. 2004 Effects of diseases on reproductive performance in Swedish red and white dairy cattle. Preventive Veterinary Medicine 66 113126 .
  35. 35. MattonP.AdelakounV.CoutureY.DufourJ. 1981 Growth and replacement of the bovine ovarian follicles during the estrous cycle. Journal of Animal Science 52 813818 .
  36. 36. MawhinneyS.RocheJ. F.GoslingJ. P. 1979 The effects of oestradiol benzoate (OB) and gonadotrophin releasing hormone (GnRH) on reproductive activity in beef cows at different intervals post partum. Annales de Biologie Animale, Biochimie, Biophysique 19 15751587 .
  37. 37. MayneC. S.Mc CoyM. A.LennoxS. D.MackeyD. R.VernerM.CatneyD. C.Mc CaugheyW. J.WylieA. R.KennedyB. W.GordonF. J. 2002 Fertility of dairy cows in Northern Ireland. Veterinary Record 150 707713 .
  38. 38. MulliganF. J.O’GradyL.RiceD. A.DohertyM. A. 2006 A herd health approach to dairy cow nutrition and production diseases of the transition cow. Animal Reproduction Science 96 331353 .
  39. 39. MulvehillP.SreenanJ. M. 1977 Improvement of fertility in postpartum beef cows by treatment with PMSG and progestagen. Journal of Reproduction and Fertilty 50 323325 .
  40. 40. MurphyM. G.BolandM. P.RocheJ. F. 1990 Pattern of follicular growth and resumption of ovarian activity in post-partum beef suckler cows. Journal of Reproduction and Fertility 90 523533 .
  41. 41. MurphyM. G.EnrightW. J.CroweM. A.Mc ConnellK.SpicerL. J.BolandM. P.RocheJ. F. 1991 Effect of dietary intake on pattern of growth of dominant follicles during the oestrous cycle in beef heifers. Journal of Reproduction and Fertilty 92333 .
  42. 42. MyersT. R.MyersD. A.GreggD. W.MossG. E. 1989 Endogenous opioid suppression of release of luteinizing hormone during suckling in postpartum anestrous beef cows. Domestic Animal Endocrinology 6 183190 .
  43. 43. NakaoT.TomitaM.KanbayashiH.TakagiH.AbeT.TakeuchiY.OchiaiH.MoriyoshiM.KawataK. 1991 Comparisons of several dosages of a GnRH analog with the standard dose of hCG in the treatment of follicular cysts in dairy cows. Theriogenology 38 137145 .
  44. 44. OpsomerG.CorynM.DeluykerH.de KruifA. 1998 An analysis if ovarian dysfunction in high yielding dairy cows after calving based on progesterone profiles. Reproduction in Domestic Animals 33 193204 .
  45. 45. OpsomerG.GrohnY. T.HertlJ.CorynM.DeluykerH.de KruifA. 2000 Risk factors for post partum ovarian dysfunction in high producing dairy cows in Belgium: a field study. Theriogenology 53 841857 .
  46. 46. OvertonT. R.WaldronM. R. 2004 Nutritional management of transitions dairy cows: strategies to optimize metabolic health. Journal of Dairy Science 87: E105 -E119.
  47. 47. PeterA. T.BosuW. T.LiptrapR. M.CummingsE. 1989 Temporal changes in serum prostaglandin F(2alpha) and oxytocin in dairy cows with short luteal phases after the first postpartum ovulation. Theriogenology 32 277284 .
  48. 48. PeterssonK. J.StrandbergE.GustafssonH.BerglundB. 2006 Environmental effects on progesterone profile measures of dairy cow fertility. Animal Reproduction Science 91 201214 .
  49. 49. RajakoskiE. 1960 The ovarian follicular system in sexually mature heifers with special reference to seasonal, cyclical. and left-right variations. Acta Endocrinology 51 168 .
  50. 50. RhodesF. M.Mc DougallS.BurkeC. R.VerkerkG. A.MacmillanK. L. 2003 Invited review: treatment of cows with an extended postpartum anestrous interval. Journal of Dairy Science 86 18761918 .
  51. 51. RichardsM. W.WettemannR. P.SchoenemannH. M. 1989 Nutritional anestrus in beef cows: body weight change, body condition, luteinizing hormone in serum and ovarian activity. Journal of Animal Science 67 15201526
  52. 52. RileyG. M.PetersA. R.LammingG. E. 1981 Induction of pulsatile LH release and ovulation in post partum cyclic beef cows by repeated small doses of GnRH. Journal of Reproduction and Fertility 63 559565 .
  53. 53. RoyalM. D.DarwashA. O.FlintA. P. F.WebbR.WoolliamsJ. A.LammingG. E. 2000 Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility. Animal Science 70 487501 .
  54. 54. RyanM.MihmM.RocheJ. F. 1998 Effect of GnRH given before or after dominance on gonadotrophin response and the fate of that follicle wave in postpartum dairy cows. Journal of Reproduction and Fertilty Abstract Series 21: 28.
  55. 55. SakaguchiM.SasamotoY.SuzukiT.TakahashiY.YamadaY. 2004 Postpartum ovarian follicular dynamics and estrous activity in lactating dairy cows. Journal of Dairy Science 87 21142121 .
  56. 56. SartoriR.HaughianJ. M.ShaverR. D.RosaG. J. M.WiltbankM. C. 2004 Comparison of ovarian function and circulating steroids in estrous cycles of Holstein heifers and lactating cows. Journal of Dairy Science 87 905920 .
  57. 57. SavioJ. D.BolandM. P.RocheJ. F. 1990a Development of dominant follicles and length of ovarian cycles in post-partum dairy cows. Journal of Reproduction and Fertilty 88 581591 .
  58. 58. SavioJ. D.BolandM. P.HynesN.RocheJ. F. 1990b Resumption of follicular activity in the early post-partum period of dairy cows. Journal of Reproduction and Fertilty 88 569579 .
  59. 59. SavioJ. D.KeenanL.BolandM. P.RocheJ. F. 1988 Pattern of dominant follicles during the oestrous cycle of heifers. Journal of Reproduction and Fertilty 83 663671 .
  60. 60. SchallenbergerE. 1985 Gonadotrophins and ovarian steroids in cattle. III. Pulsatile changes of gonadotrophin concentrations in the jugular vein post partum. Acta Endocrinology (Copenh) 109 3743 .
  61. 61. SheldonI. M.Dobson 2004 2004. Postpartum uterine health in cattle. Animal Reproduction Science 82/83 295306 .
  62. 62. SheldonI. M. 2004 The postpartum uterus. Veterinary Clinics of North America Food Animal Practice 569591 .
  63. 63. SheldonI. M.NoakesD. E.RycroftA. N.PfeifferD. U.DobsonH. 2002 Influence of uterine bacterial contamination after parturition on ovarian dominant follicle selection and follicle growth and function in cattle. Reproduction 123 837845 .
  64. 64. SheldonI. M.WilliamsE. J.MillerA. N. A.NashD. M.HerathS. 2008 Uterine diseases in cattle after parturition. The Veterinary Journal 176 115121 .
  65. 65. ShresthaH. K.NakaoT.HigakiT.SuzukiT.AkitaM. 2004 Effects of abnormal ovarian cycles during pre-service period postpartum on subsequent reproductive performance of high-producing Holstein cows. Theriogenology 61 15591571 .
  66. 66. ShresthaH. K.NakaoT.HigakiT.SuzukiT.AkitaM. 2004 Resumption of postpartum ovarian cyclicity in high-producing Holstein cows. Theriogenology 61 637649 .
  67. 67. SilveiraP. A.SpoonR. A.RyanD. P.WilliamsG. L. 1993 Evidence for maternal behavior as a requisite link in suckling-mediated anovulation in cows. Biology of Reproduction 49 13381346 .
  68. 68. SiroisJ.FortuneJ. E. 1988 Ovarian follicular dynamics during the estrous cycle in heifers monitored by real-time ultrasonography. Biology of Reproduction 39 308317 .
  69. 69. StaggK.DiskinM. G.SreenanJ. M.RocheJ. F. 1995 Follicular development in long-term anestorus suckler beef cows fed two levels of energy postpartum. Animal Reproduction Science 38 4961 .
  70. 70. StaggK.SpicerL. J.SreenanJ. M.RocheJ. F.DiskinM. G. 1998 Effect of calf isolation on follicular wave dynamics, gonadotropin, and metabolic hormone changes, and interval to first ovulation in beef cows fed either of two energy levels postpartum. Biology of Reproduction 59 777783 .
  71. 71. StaplesC. R.ThatcherW. W.ClarkJ. R. 1990 Influence of supplemental fats on reproductive tissues and performance of lactating cows. Journal of Dairy Science 81 856871
  72. 72. SunderlandS. J.CroweM. A.BolandM. P.RocheJ. F.IrelandJ. J. 1994 Selection, dominance and atresia of follicles during the oestrous cycle of heifers. Journal of Reproduction and Fertilty 101 547555 .
  73. 73. SuzukiC.YoshiokaK.IwamuraS.HiroseH. 2001 Endotoxin induces delayed ovulation following endocrine aberration during the proestrous phase in Holstein heifers. Domestic Animal Endocrinology 20 267278 .
  74. 74. TaylorV. J.BeeverD. E.BryantM. J.WathesD. C. 2003 Metabolic profiles and progesterone cycles in first lactation dairy cows. Theriogenology 59 16611677 .
  75. 75. TaylorV. J.BeeverD. E.BryantM. J.WathesD. C. 2006 Pre-pubertal measurements of the somatotrophic axis as predictors of milk production in Holstein-Friesian dairy cows. Domestic Animal Endocrinology 31 118 .
  76. 76. VanholderT.LeroyJ. L. M. R.DewulfJ.DuchateauL.CorynM.de KruifA.OpsomerG. 2005 Hormonal and metabolic profiles of high-yielding dairy cows prior to ovarian cyst formation or first ovulation post-partum. Reproduction in Domestic Animals 40 460467 .
  77. 77. WaltersD. L.ShortR. E.ConveyE. M.StaigmillerR. B.DunnT. G.KaltenbachC. C. 1982 Pituitary and ovarian function in postpartum beef cows. II. Endocrine changes prior to ovulation in suckled and nonsuckled postpartum cows compared to cycling cows. Biology of Reproduction 26 647654 .
  78. 78. WathesD. C.BourneN.ChengZ.MannG. E.TaylorV. J.CoffeyM. P. 2007 Multiple correlation analyses of metabolic and endocrine profiles with fertility in primiparous and multiparous cows. Journal of Dairy Science 90 13101325 .
  79. 79. WebbR.GarnsworthyP. C.Gong-CJ.ArmstrongD. G. 2004 Control of follicular growth: local interactions and nutritional influences. Journal of Animal Science 82: E63 -E74.
  80. 80. WilliamsE. J.FischerD. P.NoakesD. E.EnglandG. C. W.RycroftA.DobsonH.SheldonI. M. 2007 The relationship between uterine pathogen growth density and ovarian function in the postpartum dairy cow. Theriogenology 68 549559 .
  81. 81. WilliamsG. L.McveyW. R.HunterJ. F. 1993 Mammary somatosensory pathways are not required for suckling-mediated inhibition of luteinizing hormone secretion and delay of ovulation of cows. Biology of Reproduction 491328 .
  82. 82. WolfensonD.InbarG.RothZ.KaimM.BlochA.Braw-TalR. 2004 Follicular dynamics and concentrations of steroids and gonadotropins in lactating cows and nulliparous heifers. Theriogenology 62 10421055 .
  83. 83. XuZ. Z.GarverickH. A.SmithG. W.SmithM. E.HamiltonS. A.YoungquistR. S. 1995 Expression of follicle-stimulating hormone and luteinizing hormone receptor messenger ribonucleic acids in bovine follicles during the first follicular wave. Biology of Reproduction 52 464469
  84. 84. ZollersW. G.Jr GarverickH. A.SmithM. F.MoffattR. J.SalfenB. E.YoungquistR. S. 1993 Concentrations of progesterone and oxytocin receptors in endometrium of postpartum cows expected to have a short or normal oestrous cycle. Journal of Reproduction and Fertilty 97 329337 .
  85. 85. ZuluV. C.NakaoT.SawamukaiY. 2002a Insulin-like growth factor-I as a possible hormonal mediator of nutritional regulation of reproduction in cattle. Journal of Veterinary Medical Science 64 657665 .
  86. 86. ZuluV. C.SawamukaiY.NakadaD.KidaK.MoriyoshiM. 2002b Relationship among insulin-like growth factor-I blood metabolites and postpartum ovarian function in dairy cows. Journal of Veterinary Medical Science 64 879885 .

Written By

Mark A. Crowe and Michael P. Mullen

Submitted: 11 December 2011 Published: 20 February 2013