Open access peer-reviewed Edited Volume

Genes and Cancer

Edited by Guy-Joseph Lemamy

University of Health Sciences

Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment.

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IntechOpen
Genes and CancerEdited by Guy-Joseph Lemamy

Published: September 11th 2019

DOI: 10.5772/intechopen.78120

ISBN: 978-1-78984-427-6

Print ISBN: 978-1-78984-426-9

eBook (PDF) ISBN: 978-1-83881-974-3

Copyright year: 2019

Books open for chapter submissions

903 Total Chapter Downloads

1 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. N-Myc Downstream-Regulated Gene 2 (NDRG2) as a Novel Tumor Suppressor in Multiple Human Cancers

By Jian Zhang, Xia Li, Liangliang Shen, Yan Li and Libo Yao

179

Open access peer-reviewed

2. METCAM/MUC18: A Novel Tumor Suppressor for Some Cancers

By Guang-Jer Wu

140

Open access peer-reviewed

3. Tumour Suppressor Genes with Oncogenic Roles in Lung Cancer

By Mateus Camargo Barros-Filho, Florian Guisier, Leigha D. Rock, Daiana D. Becker-Santos, Adam P. Sage, Erin A. Marshall and Wan L. Lam

245

Open access peer-reviewed

4. Duplicitous Dispositions of Micro-RNAs (miRs) in Breast Cancer

By Amal Qattan

134

Open access peer-reviewed

5. Regulation of HDACi−Triggered Autophagy by the Tumor Suppressor Protein p53

By Maria Mrakovcic and Leopold F. Fröhlich

206

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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