Open access peer-reviewed Edited volume

Gene Therapy

Principles and Challenges

Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression.

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Gene TherapyPrinciples and ChallengesEdited by Doaa Hashad

Published: November 26th 2015

DOI: 10.5772/59824

ISBN: 978-953-51-2221-0

Copyright year: 2015

Books open for chapter submissions

8230 Total Chapter Downloads

5 Crossref Citations

7 Web of Science Citations

12 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Cancer Gene Therapy

By Hakan Akbulut, Muge Ocal and Gizem Sonugur

812

Open access peer-reviewed

2. Methods of Transfection with Messenger RNA Gene Vectors

By Oleg E. Tolmachov and Tanya Tolmachova

1126

Open access peer-reviewed

3. Multifunctional Delivery Systems for Cancer Gene Therapy

By Emma M. McErlean, Cian M. McCrudden and Helen O. McCarthy

746

Open access peer-reviewed

4. Gene Delivery into the Central Nervous System (CNS) Using AAV Vectors

By Koichi Miyake, Noriko Miyake and Takashi Shimada

1033

Open access peer-reviewed

5. AAV Biology, Infectivity and Therapeutic Use from Bench to Clinic

By Melisa A. Vance, Angela Mitchell and Richard J. Samulski

1744

Open access peer-reviewed

6. First Insights into Non-invasive Administration Routes for Non-viral Gene Therapy

By Ilia Villate-Beitia, Gustavo Puras, Jon Zarate, Mireia Agirre, Edilberto Ojeda and Jose Luis Pedraz

1036

Open access peer-reviewed

7. Genetically Engineered Bacteria in Gene Therapy — Hopes and Challenges

By Mustapha Chamekh

654

Open access peer-reviewed

8. Encapsulation of Transgenic Cells for Gene Therapy

By Wujie Zhang

1079

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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