Open access peer-reviewed Edited volume

Frontiers in Radiation Oncology

The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.

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Frontiers in Radiation OncologyEdited by Tejinder Kataria

Published: July 3rd 2013

DOI: 10.5772/3065

ISBN: 978-953-51-1163-4

Books open for chapter submissions

17397 Total Chapter Downloads

2 Crossref Citations

3 Web of Science Citations

3 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Histone Acetyltransferases (HATs) Involved in Non-Homologous End Joining as a Target for Radiosensitization

By Takahiro Oike, Hideaki Ogiwara, Takashi Nakano and Takashi Kohno

1098

Open access peer-reviewed

2. A Framework for Modeling the Cellular Defending Mechanisms Against Genome Stress Under Radiotherapy

By Jin-Peng Qi, Yong-Sheng Ding and Xian-Hui Zeng

436

Open access peer-reviewed

3. Applications to Radiotherapy Using Three Different Dosimetric Tools: MAGIC-f Gel, PENELOPE Simulation Code and Treatment Planning System

By Thatiane Alves Pianoschi and Mirko Salomón Alva-Sánchez

1118

Open access peer-reviewed

4. 3D Dosimetric Tools in Radiotherapy for Photon Beams

By Mirko Salomón Alva-Sánchez and Thatiane Alves Pianoschi

2092

Open access peer-reviewed

5. A Respiratory Motion Prediction Based on Time-Variant Seasonal Autoregressive Model for Real-Time Image-Guided Radiotherapy

By Kei Ichiji, Noriyasu Homma, Masao Sakai, Makoto Abe, Norihiro Sugita and Makoto Yoshizawa

806

Open access peer-reviewed

6. Neutron Dose Equivalent in Tissue Due to Linacs of Clinical Use

By S. Agustín Martínez Ovalle

1641

Open access peer-reviewed

7. Curative Radiotherapy in Metastatic Disease: How to Develop the Role of Radiotherapy from Local to Metastases

By Chul-Seung Kay and Young-Nam Kang

1248

Open access peer-reviewed

8. Locally Advanced Esophageal Cancer

By Hend Ahmed El-Hadaad and Hanan Ahmed Wahba

2385

Open access peer-reviewed

9. Reduction Mammaplasty and Intra-Operative Radiotherapy (IORT) in Conservative Surgery

By Simonetta Franchelli, Paolo Meszaros, Michela Massa, Marina Guenzi, Renzo Corvò, Davide Pertile, Giorgia Timon, Ferdinando Cafiero and Pierluigi Santi

1483

Open access peer-reviewed

10. Effects of Radiotherapy on Pharyngeal Reconstruction After Pharyngo-Laryngectomy

By Jimmy Yu-Wai Chan and Gregory Ian Siu Kee Lau

1459

Open access peer-reviewed

11. Breast Cancer Post Treatment Quality of Life

By Sabina Saric

845

Open access peer-reviewed

12. Nutrition Intervention Improves Nutritional Status and Quality of Life Outcomes in Patients Undergoing Radiotherapy

By Elisabeth Isenring

2786

Edited volume and chapters are indexed in

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  • CNKI

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