Open access peer-reviewed Edited Volume

Drug Discovery and Development

New Advances

Edited by Vishwanath Gaitonde

Cambrex High Point, Inc.

Co-editors:

Partha Karmakar

University of Washington School of Medicine

Ashit Trivedi

Amgen Inc.

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

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Drug Discovery and DevelopmentNew AdvancesEdited by Vishwanath Gaitonde

Published: March 11th 2020

DOI: 10.5772/intechopen.77685

ISBN: 978-1-78923-976-8

Print ISBN: 978-1-78923-975-1

eBook (PDF) ISBN: 978-1-78985-219-6

Copyright year: 2020

Books open for chapter submissions

5626 Total Chapter Downloads

6 Crossref Citations

19 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: The Modern-Day Drug Discovery

By Partha Karmakar, Ashit Trivedi and Vishwanath Gaitonde

258

Open access peer-reviewed

2. Past, Present, and Future of Molecular Docking

By Thuluz Meza Menchaca, Claudia Juárez-Portilla and Rossana C. Zepeda

554

Open access peer-reviewed

3. Molecular Docking in Modern Drug Discovery: Principles and Recent Applications

By Aaftaab Sethi, Khusbhoo Joshi, K. Sasikala and Mallika Alvala

2131

Open access peer-reviewed

4. Computational Deorphaning of Mycobacterium tuberculosis Targets

By Lorraine Yamurai Bishi, Sundeep Chaitanya Vedithi, Tom L. Blundell and Grace Chitima Mugumbate

493

Open access peer-reviewed

5. Revisiting Pharmacokinetics and Pharmacogenetics of Methadone in Healthy Volunteers

By Natalia Guevara, Marianela Lorier, Marta Vázquez, Pietro Fagiolino, Iris Feria-Romero and Sandra Orozco-Suarez

475

Open access peer-reviewed

6. ADME Profiling in Drug Discovery and a New Path Paved on Silica

By Arne Krüger, Vinicius Gonçalves Maltarollo, Carsten Wrenger and Thales Kronenberger

848

Open access peer-reviewed

7. Successive Drug Therapy for a Very Rare Autosomal Diseases

By Mohammed Chyad Al-Noaemi and Hassan Ali Daghriri

217

Open access peer-reviewed

8. Challenges and New Frontiers in the Paediatric Drug Discovery and Development

By Angelica Intini, Donato Bonifazi and Giovanni Migliaccio

661

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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