Open access peer-reviewed Edited volume

Drosophila melanogaster

Model for Recent Advances in Genetics and Therapeutics

Edited by Farzana Khan Perveen

Shaheed Benazir Bhutto Universit

This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

Read more >Order hardcopy
IntechOpen
Drosophila melanogasterModel for Recent Advances in Genetics and TherapeuticsEdited by Farzana Khan Perveen

Published: February 28th 2018

DOI: 10.5772/66545

ISBN: 978-953-51-3854-9

Print ISBN: 978-953-51-3853-2

Books open for chapter submissions

1381 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Introduction to Drosophila

By Farzana Khan Perveen

137

Open access peer-reviewed

2. Drosophila Chromosomal Polymorphism: From Population Aspects to Origin Mechanisms of Inversions

By Carolina Garcia and Vera L. S. Valente

123

Open access peer-reviewed

3. Cell Cycle Regulators in Female Meiosis of Drosophila melanogaster

By Mohammed Bourouh and Andrew Swan

94

Open access peer-reviewed

4. Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

By Brian Xia and J. Steven de Belle

129

Open access peer-reviewed

5. Drosophila Imaginal Discs as a Playground for Genetic Analysis: Concepts, Techniques and Expectations for Biomedical Research

By Cristina M. Ostalé, Ana Ruiz-Gómez, Patricia Vega, Mireya Ruiz- Losada, Carlos Estella and Jose F. de Celis

92

Open access peer-reviewed

6. The Fruit Fly, Drosophila melanogaster: The Making of a Model (Part I)

By Mariateresa Allocca, Sheri Zola and Paola Bellosta

140

Open access peer-reviewed

7. The Fruit Fly, Drosophila melanogaster: Modeling of Human Diseases (Part II)

By Mariateresa Allocca, Sheri Zola and Paola Bellosta

149

Open access peer-reviewed

8. Parkinson’s Disease: Insights from Drosophila Model

By Mohamad Ayajuddin, Abhik Das, Limamanen Phom, Priyanka Modi, Rahul Chaurasia, Zevelou Koza, Abuno Thepa, Nukshimenla Jamir, Pukhrambam Rajesh Singh, Sentinungla Longkumer, Pardeshi Lal and Sarat Chandra Yenisetti

111

Open access peer-reviewed

9. Drosophila Model in the Study Role of UCH-L1

By Dang Thi Phuong Thao

88

Open access peer-reviewed

10. Swiss Cheese, Drosophila Ortholog of Hereditary Spastic Paraplegia Gene NTE, Maintains Neuromuscular Junction Development and Microtubule Network

By Elena Ryabova, Nataliya Matiytsiv, Olena Trush, Iryna Mohylyak, Galina Kislik, Pavel Melentev and Svetlana Sarantseva

120

Open access peer-reviewed

11. Substrate Specificities and Kinetic Parameters of Recombinant Drosophila melanogaster Glutathione S-Transferases E6 and E7

By Vennobaashini Venu and Zazali Alias

73

Open access peer-reviewed

12. Antiviral Immunity in the Fruit Fly, Drosophila melanogaster

By Wilfredo A. Lopez, Alexis M. Page, Brad L. Ericson, Darby J. Carlson and Kimberly A. Carlson

125

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited volume

Free shipping with DHL Express

Hardcover (ex. VAT)£140

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase