Open access peer-reviewed Edited Volume

Drosophila melanogaster

Model for Recent Advances in Genetics and Therapeutics

Edited by Farzana Khan Perveen

Shaheed Benazir Bhutto University

This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

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Drosophila melanogasterModel for Recent Advances in Genetics and TherapeuticsEdited by Farzana Khan Perveen

Published: February 28th 2018

DOI: 10.5772/66545

ISBN: 978-953-51-3854-9

Print ISBN: 978-953-51-3853-2

eBook (PDF) ISBN: 978-953-51-4011-5

Copyright year: 2018

Books open for chapter submissions

22390 Total Chapter Downloads

20 Crossref Citations

13 Web of Science Citations

30 Dimensions Citations


Open access peer-reviewed

1. Introduction to Drosophila

By Farzana Khan Perveen


Open access peer-reviewed

2. Drosophila Chromosomal Polymorphism: From Population Aspects to Origin Mechanisms of Inversions

By Carolina Garcia and Vera L. S. Valente


Open access peer-reviewed

3. Cell Cycle Regulators in Female Meiosis of Drosophila melanogaster

By Mohammed Bourouh and Andrew Swan


Open access peer-reviewed

4. Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

By Brian Xia and J. Steven de Belle


Open access peer-reviewed

5. Drosophila Imaginal Discs as a Playground for Genetic Analysis: Concepts, Techniques and Expectations for Biomedical Research

By Cristina M. Ostalé, Ana Ruiz-Gómez, Patricia Vega, Mireya Ruiz- Losada, Carlos Estella and Jose F. de Celis


Open access peer-reviewed

6. The Fruit Fly, Drosophila melanogaster: The Making of a Model (Part I)

By Mariateresa Allocca, Sheri Zola and Paola Bellosta


Open access peer-reviewed

7. The Fruit Fly, Drosophila melanogaster: Modeling of Human Diseases (Part II)

By Mariateresa Allocca, Sheri Zola and Paola Bellosta


Open access peer-reviewed

8. Parkinson’s Disease: Insights from Drosophila Model

By Mohamad Ayajuddin, Abhik Das, Limamanen Phom, Priyanka Modi, Rahul Chaurasia, Zevelou Koza, Abuno Thepa, Nukshimenla Jamir, Pukhrambam Rajesh Singh, Sentinungla Longkumer, Pardeshi Lal and Sarat Chandra Yenisetti


Open access peer-reviewed

9. Drosophila Model in the Study Role of UCH-L1

By Dang Thi Phuong Thao


Open access peer-reviewed

10. Swiss Cheese, Drosophila Ortholog of Hereditary Spastic Paraplegia Gene NTE, Maintains Neuromuscular Junction Development and Microtubule Network

By Elena Ryabova, Nataliya Matiytsiv, Olena Trush, Iryna Mohylyak, Galina Kislik, Pavel Melentev and Svetlana Sarantseva


Open access peer-reviewed

11. Substrate Specificities and Kinetic Parameters of Recombinant Drosophila melanogaster Glutathione S-Transferases E6 and E7

By Vennobaashini Venu and Zazali Alias


Open access peer-reviewed

12. Antiviral Immunity in the Fruit Fly, Drosophila melanogaster

By Wilfredo A. Lopez, Alexis M. Page, Brad L. Ericson, Darby J. Carlson and Kimberly A. Carlson


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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