Open access peer-reviewed Edited Volume

DNA Repair and Human Health

Edited by Sonya Vengrova

University of Warwick, United Kingdom

Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers.

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DNA Repair and Human HealthEdited by Sonya Vengrova

Published: October 26th 2011

DOI: 10.5772/1750

ISBN: 978-953-307-612-6

Copyright year: 2011

Books open for chapter submissions

56882 Total Chapter Downloads

5 Crossref Citations

24 Web of Science Citations

29 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. DNA Repair, Human Diseases and Aging

By Vaidehi Krishnan, Baohua Liu and Zhongjun Zhou

3352

Open access peer-reviewed

2. Double Strand Break Signaling in Health and Diseases

By Marie-jo Halaby and Razqallah Hakem

1598

Open access peer-reviewed

3. DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants

By Augusto Nogueira, Raquel Catarino and Rui Medeiros

3715

Open access peer-reviewed

4. The Role of Error-Prone Alternative Non-Homologous End-Joining in Genomic Instability in Cancer

By Li Li, Carine Robert and Feyruz V. Rassool

2425

Open access peer-reviewed

5. Nucleotide Excision Repair and Cancer

By Joost P.M. Melis, Mirjam Luijten, Leon H.F. Mullenders and Harry van Steeg

1527

Open access peer-reviewed

6. Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum

By Carolina Quayle, Carlos Frederico Martins Menck and Keronninn Moreno Lima-Bessa

1312

Open access peer-reviewed

7. DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy

By Ana M. Urbano, Leonardo M. R. Ferreira, Joana F. Cerveira, Carlos F. Rodrigues and Maria C. Alpoim

1893

Open access peer-reviewed

8. DNA Repair, Cancer and Cancer Therapy

By Mu Wang

1583

Open access peer-reviewed

9. DNA Repair, Cancer and Cancer Therapy - The Current State of Art

By Turgay Isbir, Berna Demircan, Deniz Kirac, Burak Dalan and Uzay Gormus

1576

Open access peer-reviewed

10. Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

By Anna Tompa, Jenő Major and Mátyás G. Jakab

1656

Open access peer-reviewed

11. Hypoxia Inhibits DNA Repair to Promote Malignant Progression

By L. Eric Huang, Young-Gun Yoo, Minori Koshiji and Kenneth K.W. To

1271

Open access peer-reviewed

12. From the Molecular Biology to the Gene Therapy of a DNA Repair Syndrome: Fanconi Anemia

By Paula Río, Susana Navarro and Juan A. Bueren

953

Open access peer-reviewed

13. Fanconi Anemia/Brca Pathway and Head and Neck Squamous Cell Carcinomas

By Shi-Long Lu

2029

Open access peer-reviewed

14. DNA Repair Deficiency Associated with Hematological Neoplasms

By Panagiota Economopoulou, Vassiliki Pappa, Sotirios Papageorgiou, John Dervenoulas and Theofanis Economopoulos

1665

Open access peer-reviewed

15. DNA Repair in Acute Myeloid Leukemia and Myelodysplastic Syndromes

By Anna Szmigielska-Kaplon and Tadeusz Robak

2109

Open access peer-reviewed

16. Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells

By Haiyan Wang, Shanbao Cai, Eva Tonsing-Carter and Karen E. Pollok

1353

Open access peer-reviewed

17. DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms

By Susana N. Silva, Bruno Costa Gomes, José Rueff and Jorge Francisco Gaspar

1755

Open access peer-reviewed

18. DNA Mismatch Repair (MMR) Genes and Endometrial Cancer

By Kenta Masuda, Kouji Banno, Megumi Yanokura, Iori Kisu, Arisa Ueki, Asuka Ono, Yusuke Kobayashi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu and Daisuke Aoki

2811

Open access peer-reviewed

19. Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer

By Rachel M. Abbotts, Christina Perry and Srinivasan Madhusudan

1270

Open access peer-reviewed

20. Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy

By Tracy M. Neher, Wei Huang, Jian-Ting Zhang and John J. Turchi

2063

Open access peer-reviewed

21. Pharmacogenomic Approach of Telomerase in Cancer: Importance of End Zone Variability

By R. Catarino, A. Nogueira, A. Coelho and R. Medeiros

962

Open access peer-reviewed

22. Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells

By Christine Granotier and François D. Boussin

1854

Open access peer-reviewed

23. Pharmacogenetics of Cancer and DNA Repair Enzymes

By Tahar van der Straaten, Leon Mullenders and Henk-Jan Guchelaar

1719

Open access peer-reviewed

24. Involvement of Histone PTMs in DNA Repair Processes in Relation to Age-Associated Neurodegenerative Disease

By Chunmei Wang, Erxu Pi, Qinglei Zhan and Sai-ming Ngai

1834

Open access peer-reviewed

25. Transcriptional Functions of DNA Repair Proteins Involved in Premature Aging

By Robin Assfalg and Sebastian Iben

1231

Open access peer-reviewed

26. DNA Damage and mRNA Levels of DNA Base Excision Repair Enzymes Following H2O2 Challenge at Different Temperatures

By Kyungmi Min and Susan E. Ebeler

1387

Open access peer-reviewed

27. Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency Syndromes

By Sarah Vose and James Mitchell

3013

Open access peer-reviewed

28. The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration

By Kei Adachi and Hiroyuki Nakai

1548

Open access peer-reviewed

29. Integration of the DNA Damage Response with Innate Immune Pathways

By Gordon M. Xiong and Stephan Gasser

1905

Open access peer-reviewed

30. Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer

By Harpreet K. Dibra, Chris J. Perry and Iain D. Nicholl

1982

Open access peer-reviewed

31. Inhibition of DNA Polymerase λ, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives

By Yoshiyuki Mizushina, Masayuki Nishida, Takeshi Azuma and Masaru Yoshida

1531

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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