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Medicine » "COPD - An Update in Pathogenesis and Clinical Management", book edited by Cormac McCarthy, ISBN 978-953-51-3783-2, Print ISBN 978-953-51-3782-5, Published: February 21, 2018 under CC BY 3.0 license. © The Author(s).

Chapter 7

Advances in Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease and Associated Conditions

By Ipek Candemir
DOI: 10.5772/intechopen.70920

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Advances in Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease and Associated Conditions

Ipek Candemir
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Pulmonary rehabilitation (PR) is an evidenced-based, proven treatment as mentioned recent guidelines in patients with chronic obstructive pulmonary disease (COPD). Exercise training is a cornerstone of PR programs, Inspiratory muscle training, neuromuscular electrical stimulation (NMES) are effective in selected patients. Water-based rehabilitation and tai chi are well tolerated recent modalities. Although there is an absence of a specific PR protocol for special conditions, PR is recommended before and also after endobronchial volume reduction (EBVR), lung volume reduction surgery (LVRS), both before and after lung transplantation periods, before, after surgery, during the intensive care unit (ICU) period, the chemotherapy period and as a component of palliative care. After COPD exacerbation, it is recommended within 3 weeks of hospital discharge. Modifying PR programs while considering comorbidities might lead to greater improvement in outcomes. After PR, the important points are to follow prescribed home exercise programs, control programs in the PR center/unit, and being more active in daily living life for the purpose of preserving improvements. Tele-PR is an alternative to conventional modalities due to similar improvements. Although PR is effective, it is an under-utilized resource. The awareness of PR should be increased in patients and among health professionals.

Keywords: PR, exercise capacity, quality of life, perioperative lung transplantation, EBVR

1. Introduction

Chronic obstructive pulmonary disease (COPD), a systemic progressive disease that results in reduced exercise capacity and quality of life, progressive dyspnea, and mortality. It causes health and economic burdens unless pharmacologic and nonpharmacologic treatments are optimized. One of the most important interventions is pulmonary rehabilitation (PR). It is a proven modality and is included in COPD treatment guidelines. The evidence-based benefits are improvement in exercise capacity and quality of life, recovery time after hospitalization, and survival; and reduction in perceived intensity of breathlessness, number of hospitalizations, and days in hospital; and enhancement of the effect of long-acting bronchodilators. Although most studies included patients with moderate-to-severe COPD and demonstrated evidence for these patients, PR is recommended for all patients who are symptomatic with reduced exercise capacity and quality of life, regardless of disease severity. PR is also an effective, feasible modality during the intensive care unit (ICU) period and early periods after exacerbation. The recommended time for PR is during the perioperative period in lung transplantation. Additionally, PR is required before endobronchial volume reduction (EBVR) and has shown to be beneficial before and after lung cancer surgery. This chapter outlines the pathophysiologies that give rise to indications for PR, the latest developments in PR, and PR modalities associated with COPD.

2. The definition of PR

PR is described as “a comprehensive intervention based on a thorough patient assessment followed by patient-tailored therapies that include, but are not limited to, exercise training, education, and behavior changes, that is designed to improve the physical and psychological conditions of people with chronic respiratory disease, and to promote the long-term adherence to health-enhancing behaviors [1].”

3. Pathophysiologies indicated for PR

3.1. Exercise limitation

Exercise intolarence is one of the most important and common symptoms experienced by patients with mild-to-severe COPD and are related to reduced health-related quality of life. Exercise intolerance in patients with COPD is primarily due to impaired ventilatory mechanics, but it is also associated with gas exchange limitation, cardiovascular factors, peripheral skeletal muscle dysfunction and a combination of these [2, 3]. Additionally, anxiety and poor motivation are other factors of exercise intolerance. Although the exact association has yet to be found, it is thought that anxiety and depression contribute to exercise intolerance [4], due to the effect that these have on increased symptom perception [5, 6].

Ventilatory limitation: Multiple factors determine ventilatory limitation, which consists of abnormalities in ventilatory mechanics and ventilatory muscle function. Other reasons for ventilatory limitation are increased ventilatory demands as a result of changes in gas exchange, and discordance in the neuroregulatory control of breathing. The most important pathophysiology in patients with COPD is expiratory flow limitation. During exercise, air becomes trapped, which results in dynamic lung hyperinflation (DH) above the already increased resting volumes. Additionally, DH inhibits tidal volume expansion during exercise and contributes to cardiac dysfunction by increasing the positive intrathoracic pressures, which likely contribute to cardiac impairment [7].

Gas exchange limitation: Hypoxia is likely to limit exercise tolerance. Hypoxia increases pulmonary ventilation by enhancing output of peripheral chemoreceptors and production of lactic acid. Lactic acidemia results in increased pulmonary ventilation because of an increase in carbon dioxide production due to buffered lactic acid [8]. Above the lactic threshold, severe dyspnea correlates with increased work rates. Dyspnea may quickly increase. Furthermore, plasma norepinephrine and epinephrine also increase during exercise [9, 10].

Cardiovascular factors: In patients with COPD, the cardiovascular system is influenced by various mechanisms. The most important is an increase in right ventricular afterload through elevated pulmonary vascular resistance from direct vascular injury [11, 12], hypoxic vasoconstriction [13], and/or increases in effective pulmonary vascular resistance due to erythrocytosis [14]. In the course of time, the overloaded right ventricle leads to right ventricular hypertrophy, which could result in right ventricular failure [15]. During exercise, pulmonary vascular resistance is rapidly increased due to breathing at lung volumes close to total lung capacity [16, 17]. Lung hyperinflation and excessive expiratory muscle recruitment are likely to reduce venous return and right ventricular preload in COPD [18, 19]. Moreover, during exercise, large intrathoracic pressure swings for the purpose of overcoming the increased elastic and resistive loads, may result in left ventricular dysfunction by increasing left ventricular afterload [20, 21]. These right ventricular effects can also compromise left ventricular filling through septal shifts that further reduce the ability of the heart to meet exercise demands [22].

Peripheral skeletal muscle dysfunction: Skeletal muscle dysfunction in patients with COPD is characterized by remarkably decreased muscle strength and endurance. The mechanisms are reduction in muscle mass and proportion of oxidative fibers, increases in the proportion of glycolytic fibers and muscle atrophy, and also a detoriation of oxidative metabolic capacity due to reductions in mitochondrial enzyme activities and capillary density. Additionally, systemic inflammation; malnutrition; corticosteroid use; hypoxemia; aging; smoking; the production of reactive oxygen and nitrogen species; enhanced protein degradation inside muscle fibers; increased activities of the proteasomal and lysosomal pathways; and activation of calpains and caspases contribute to muscle dysfunction. Therefore, patients with COPD enter into a vicious circle owing to disuse and inactivity due to the aforementioned mechanisms [23].

3.2. Body composition disorders

Unexplained weight loss occurs in about 50% of patients with severe COPD and 15% of patients with mild-to-moderate COPD [24, 25]. The main cause of weight loss in COPD is the reduction in skeletal muscle mass rather than loss of fat mass. Based on the reduction of fat mass or fat-free mass index (FFMI), nutritional abnormalities in COPD have been categorized into four types. Normal body mass index (BMI) with normal FFMI is normal, low BMI with normal or above-normal FFMI is defined as semistarvation, normal or above-normal BMI with low FFMI is defined as muscle atrophy, and low BMI with low FFMI as cachexia [26]. There are several reasons for weight loss in patients with COPD, even if during a stable period. In patients with stable COPD, there is an increased metabolic rate due to abnormal respiratory dynamics, chronic systemic inflammation, and drugs [27, 28, 29, 30, 31]. In malnourished mobile patients with COPD, although the basal metabolic rate is reduced, the resting energy expenditure is high. During exercise, inefficient muscle contractions due to increased consumption of adenosine triphosphate are added on. Also, there is an increase in the levels of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL) 1 in circulation. TNF-α and IL1 have been shown to contribute to weight loss even in healthy individuals [32].

3.3. Psychological status

Patients with COPD have a higher prevalence of depression and anxiety than the general population [33] and a higher risk for developing depression [34]. The etiology of the association between depression and COPD has not been revealed clearly. The most important risk factor for COPD is smoking. Depressed individuals are more likely to smoke [35], have a tendency to smoking [36, 37], and find smoking cessation more difficult [35, 38]. Conversely, smokers are more likely to be depressed [39], which could be caused by activation of nicotinic acetylcholine receptors [40], and the inflammatory effects of smoking [41]. Soluble tumor necrosis factor receptor-1 has shown to be associated with rates of depression in patients with COPD [42], but there is not exact relationship between TNF-α and COPD [43, 44]. Hypoxia is thought be an additional factor in the development of depression in COPD. Low arterial oxygen saturation has been shown to be associated with periventricular white matter lesions [45], which are found in patients with depression [46]. Other important risk factors are the severity of symptoms and reported quality of life [47]. Depression is found more frequently in support-bound patients with COPD [48].

4. Content of PR programs

4.1. Exercise training

Exercise training is a cornerstone of PR programs. Exercise training is shown to be the best approach for increasing muscle strength, is likely to improve motivation for exercise, reduce mood abnormalities [49, 50], decrease symptoms [51], and improve cardiovascular function [1]. As recent major guidelines recommend, the main components of exercise training programs for patients with COPD are endurance and resistance training, which should be included in PR programs. Although none of the guidelines make clear, specific, and accurate recommendations for whole exercise training, they agree on endurance training at least 3 to 5 times weekly >60% of the maximal work rate. However, there is no consensus of initial workloads or in increasing the exercise load or program duration; the duration of exercise is recommended for at least 20 minutes and a target program duration of up to 12 weeks [52].

Inspiratory muscle training (IMT): Respiratory muscle training is a part of rehabilitation in selected patients with COPD. Respiratory strength has been found to correlate with improved pulmonary function, reduction of dyspnea severity, improved exercise tolerance, and enhanced functionality and quality of life [53, 54]. IMT is thought to contribute to contraction of the diaphragm by increasing type II fibers [55], which results in reduced inspiratory time [56] and subsequently increased expiratory time. Hyperinflation is expected to eventually diminish [57]; therefore, IMT is thought to impact on dyspnea without any significant change in inspiratory pressure [58, 59].

Neuromuscular electrical stimulation (NMES): NMES is one of the recent rehabilitation modalities that involve passive stimulation of contraction of the peripheral muscles through the application of an electric current via electrodes placed on the skin over the targeted muscles by depolarizing motor neurons. It aims to elicit beneficial training effects without causing dyspnea in patients who are unable to participate in PR programs. The stimulation-pulse duration is usually 250–400 μs, and stimulation frequency ranges from 8 to 120 Hz. Intensities range from 10 to 100 mA, and these are gradually increased throughout the entire stimulation according to the patient’s individual tolerance. In a meta-analysis published in 2016, it was found that NMES improved quadriceps strength and exercise capacity; however, there was no statistically significant improvement in the degree of health-related quality of life in patients with moderate-to-severe COPD [60]. In several studies, it has been reported that NMES had an impact on the increase in type II fiber cross-sectional area with a decrease in type I fiber cross-sectional area of the muscle, and on the decrease in muscle oxidative stress in patients with COPD. Owing to the fact that NMES has a low impact on ventilation, heart rate, and dyspnea, it could be applied during periods of exacerbation, and during admission to the ICU for acute COPD exacerbation [61, 62].

Recent exercise training approaches: Besides conventional exercise trainings, there have been a few papers published recently about alternative exercise training modalities in patients with COPD. According to these studies, water-based rehabilitation [63] and tai chi were found as well tolerated and enjoyable [64, 65].

4.2. Other interventions

PR programs should be comprehensive and individualized according to patients’ needs. Other interventions are breathing strategies, bronchial hygiene techniques, psychological and nutritional recommendations and support if needed, and education of patients and care givers. Body composition abnormalities, especially malnutrition, have already been found to increase risks of mortality among patients with COPD. A significant improvement has been shown in pulmonary function in patients with COPD who have a higher fat, lower carbohydrate diet than the traditional high-carbohydrate diet [66]. Omega-3 polyunsaturated fatty acids (PUFA) have been shown to have an antiinflammatory effect and be effective in patients with COPD [67]. It is also important to relapse any deficiency of vitamin D due to the association with early progression, myopathy/muscle weakness, and the immune-modulatory effect of vitamin D [27].

5. Outcomes and response to PR

It has been demonstrated that PR is the most effective therapeutic approach for improving dyspnea, health status, and exercise tolerance [68]. It is also one of the most cost effective therapeutic strategies. Additionally, it reduces hospitalizations among patients who have had recent exacerbations [69]. Improvements are seen among all grades of COPD severity, but recommendations are stronger in moderate-to-severe COPD. In some studies, improvements of outcomes were seen regardless of baseline lung function, dyspnea, and exercise capacity [70].

5.1. Exercise capacity

Various exercise tests are used for evaluating exercise capacity, the mechanisms of main disruption, and the response to PR. Some are also strong independent prognostic factors in patients with COPD. There are several laboratory-based exercise tests that use either maximal incremental or constant workload protocols to evaluate exercise performance after PR. Field tests are more widely used and more practical to perform. The six-minute walk test (6MWT), incremental and endurance shuttle walk test (ISWT, ESWT) are standardized and have also been used in PR and various clinical trials. In COPD, endurance tests [constant work rate exercise test (CWRET) and ESWT] are more responsive to interventions than other types of tests. The cycle ergometer CWRET has been used more widely than ESWT. By using CWRET, the work rate, inspiratory capacity, and isotime responses, which verify potential mechanisms of improvement or deterioration, are accurately measured [71].

The ISWT is a significant predictor of survival, readmission, and is usually sensitive to PR in patients with COPD [72]. In a recent meta-analysis of nine trials, a mean improvement of 38 m was found [68]. After recovering from a stay in the ICU, ISWT was found to improve by a mean of 64 m after rehabilitation [72]. ESWT duration was found as moderately correlated with FEV1, but not with muscle mass or strength in patients with COPD [73]. ESWT is responsive to PR improving by 100–400 s. [71]. According to a meta-analysis of rehabilitative interventions in COPD, the mean effect of rehabilitation on 6MWD was 44 m when treatment and control groups were compared [74].

Peak oxygen uptake (V′O2peak) shows the highest oxygen uptake during incremental exercise tests by achieving the subject’s limit of tolerance. With good subject effort, V′O2peak is closely reflective of the subject’s “maximum” V′O2, the gold standard index of aerobic capacity [75]. There is very little information about what constitutes a minimal clinically important difference (MCID) in V′O2peak. In the National Emphysema Treatment Trial (NETT), 4 ± 1 W was considered the symptoms-anchored MCID in patients with severe COPD [76], with a V′O2peak change of ∼0.04 ± 0.01 L·min−1. In several studies including patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 2–4 COPD V′O2peak has been shown to moderately significantly increase after lower limb endurance muscle training. After PR in patients with COPD, V′O2peak was found to be in the range 0.1–0.5 L·min−1 or ∼10–40% of baseline, with a mean improvement of ∼11% [77, 78].

5.2. Health-related quality of life daily living activities

In a recent study, it was aimed to determine the responsiveness of St. George’s Respiratory Questionnaire (SGRQ), COPD Assessment Test (CAT), COPD Clinical Questionnaire (CCQ), and Hospital Anxiety and Depression Scale (HADS) to PR in 419 patients with COPD, and also estimate the MCID for CAT, CCQ, and HADS. It was demonstrated that SGRQ, CAT, CCQ, and HADS were responsive to PR in patients with moderate-to-very-severe COPD. The calculated MCID ranges were −3.0 to −2.0 points for CAT; −0.5 to −0.3 points for CCQ; −1.8 to −1.3 points for HADS-A, and −1.7 to −1.5 points for HADS-D [79].

6. PR in special conditions

6.1. Before and after transplantation

Lung transplantation is a recommended intervention in patients with advanced-stage pulmonary disease who are unresponsive to pharmacologic and nonpharmacologic treatment. Factors such as chronic respiratory failure, cardiovascular risk factors, muscular and nutritional conditions, which are likely to influence the prognosis for a successful lung transplantation, usually accompany advanced chronic respiratory disorders. Therefore, PR is an important approach that modifies and controls potential risk factors. PR plays an important role for the maintenance of exercise tolerance and physical functioning [80] both before and after the lung transplantation because common extra pulmonary manifestations could be persistent or deteriorate. As such, PR is recommended both before and after lung transplantation. Although there is an absence of a specific PR protocol for patients for lung transplant, it was shown to improve maximal and functional exercise capacity, quality of life, and skeletal muscle function [81].

Before transplantation: The role of PR in preoperative patients is essential for quitting smoking, improving body composition, optimizing medical treatment, and restoring patients’ independence for functioning, relieving symptoms, decreasing disability, and improving quality of life by increasing their participation in social and physical activities. It has been shown that the rate of success in lung transplantation was linked to exercise capacity and resting carbon dioxide in arterial blood values [82]. Those parameters were also found to predict hospital stay after surgery and mortality. Additionally, pretransplant PR was also found to be associated with decreased posttransplant ICU days, mechanical ventilation, and chest tube days and survey [83]. Multidisciplinary, comprehensive PR must be individualized and the modality and intensity of training must be selected for each patient. The duration of training can vary from 6 weeks to 6 months [84]. The program should consist of education (including the following topics: bronchial hygiene, breathing control techniques, relaxation, education about COPD, and education of relatives and energy conservation), exercise training (upper and lower limb aerobic exercise, resistance training, flexibility, inspiratory muscle training), psychological support, and nutritional support. The intensity of exercise is dynamically increased according to the progress of each individual patient.

After transplantation: Although pulmonary functions are improved after transplantation, limited exercise capacity is persistent due to different mechanisms. Persistent limited exercise capacity is not only associated with ventilatory or cardiovascular factors [85, 86], skeletal muscle dysfunction is the main problem. Skeletal muscle changes include impaired oxidative capacity, lactate threshold changes, and a lower proportion of type I muscle fibers [87]. A sedentary life style both before and after transplantation contributes to skeletal muscle weakness [88]. Hospitalizations due to infections or acute rejections and the use of immunosuppressive medication further impact muscle function in lung recipients [89]. It was found that V′O2 peak was 45–52% predicted in patients after lung transplantation for up to 2 years. Patients stop exercise because of leg fatigue, rather than dyspnea [90]. Additionally, maximal cycle-work capacity correlates better with isokinetic cycling work capacity than with pulmonary function after lung transplantation [91]. PR should be started in the ICU with positioning of the patient, ventilation of all lung lobes, and mobilization of secretions by managing cough. Deep breathing exercises should be initiated because tachypnoea and pursed-lip breathing persist postoperatively and old breathing patterns must be overcome. Sitting and mobilization out of bed should then be performed. After all chest drains have been removed, walking or cycle ergometry should performed. Muscle strength and function, and endurance training should focus on lower extremities, and weights can be limited to 3 kg initially for upper extremities [92]. After discharge, patients should be referred to PR center/units as soon as possible. Although there is no consensus on optimal exercise training and education programs, aerobic and strength exercise training of the lower and upper extremities 2–3 times per week for 6–8 weeks, are recommended. The intensity of exercise can be increased according to patient tolerance. High-intensity aerobic exercise training at 60–80% of maximal work capacity has been found to be correlated with physiologic improvements in patients with stable COPD. Hence, high-intensity training is preferred. Interval training could be applied in patients who cannot sustain continuous high-intensity. Stretching, flexibility, and chest-mobility exercises may also be an important component of exercise after LVRS or transplantation [1, 82, 93]. Education of patients and care givers is also an important issue.

6.2. Lung volume resection surgery (LVRS)

Similar recommendations are valid for LVRS, which is not usually an effective intervention for exercise intolerance and functional disability. Baseline skeletal muscle dysfunction, time needed to achieve postoperative improvement in lung function (peak benefits are usually seen 6–12 months after surgery), and inactivity/immobility associated with the perioperative period are factors that reduce exercise capacity. Several studies compared the benefits of LVRS and several-weeks’–duration comprehensive PR in patients with severe emphysema. PR was found to significantly improve exercise tolerance, health status, and dyspnea, without significant changes in lung function as compared with PR and LVRS, even if highly selected patients showed significantly better improvement in lung function [94, 95, 96, 97], exercise capacity [95, 96, 97], and quality of life [96, 97].

6.3. Endobronchial volume reduction (EBVR)

Endobronchial volume reduction interventions result in improved spirometric measures and 6MWD at 6 months, only if in correctly selected subjects. PR is recommended before and after EBVR, which is indicated in the presence of persistent dyspnea despite maximal medical therapy and PR, and reduced exercise capacity (6MWD ≥140 m after rehabilitation) [97].

6.4. Lung cancer

In patients with lung cancer, exercise limitations can be due to the effects of the cancer, coexisting morbidities, and/or the effects of treatment and surgery. Cancer-related anemia, and muscle atrophy and dysfunction contribute to limited exercise capacity. Inactivity due to cancer and its comorbidities further compound this situation. In the pre- and postoperative period, quitting smoking, optimizing COPD medical treatment, educating patients, prophylaxis for thrombosis, and PR are the recommended approaches that decrease risks. PR is an effective and feasible intervention before and after surgery, during the chemotherapy period, and as a component of palliative care. Even though PR consists of an exercise program for lower and upper extremities, breathing, airway clearance techniques, oxygen therapy, bronchodilator optimization, and self-management training similar to other conditions, it should also be individualized and multidisciplinary in patients with cancer.

Even though surgical procedures have improved and patients are highly selected, morbidity and mortality rates are still increasing as a consequence of cardiopulmonary complications after surgery. Limited exercise capacity as a modifiable risk factor is the best independent predictor of postoperative complications. Multidisciplinary preoperative PR improves exercise capacity and postoperative recovery, and reduces hospital stay and pulmonary infections [98]. During the chemotherapy period, symptoms such as fatigue, breathlessness, and quality of life are likely to deteriorate. Exercise training improves fatigue, aerobic capacity, muscular strength, and physical and functional activity in patients with cancer, even though they are undergoing chemotherapy [99]. Breathing techniques and medications that result in reduced inflammation and opened airways in combination with exercise training have recently become a part of supportive care for patients undergoing chemotherapy and radiation therapy [100]. PR plays a role in the management of terminal cancer. Exercise training modalities include walking with/without assistance or device, passive or active strengthening exercises, continuous passive motion, passive or active range of motion, NMES, and pain management interventions such as massage and heating pads [101]. Oxygen therapy has an important role in palliative care because it both treats hypoxemia and reduces the sensation of dyspnea. Additionally, education about mobilization with assistive devices, environmental modification, energy conservation, and work simplification techniques are also beneficial. These interventions have been investigated and were shown to be effective in cancer-related fatigue in several studies [102, 103, 104]. In another study, it was shown that exercise training decreased anxiety, stress, depression, and there were improvements in pain, fatigue, shortness of breath, constipation, and insomnia in patients with cancer, even at advanced stages [105].

6.5. Exacerbation of COPD

COPD exacerbations are known to deteriorate life quality, disease progression, and mortality. The British Thoracic Society (BTS) recommends the initiation of PR within 1 month of hospital discharge after exacerbation, consisting of a minimum of twice-weekly supervised sessions lasting between 6 and 12 weeks [106]. Exercise should combine progressive muscle resistance and aerobic training [106]. Systematic reviews have shown that quality of life and daily functioning were improved with large and important clinical effects of PR [107, 108]. According to the European Respiratory Society (ERS)/American Thoracic Society (ATS) guidelines of management of COPD exacerbations, PR added to medical treatment during hospitalization increases mortality [109]; however, NMES and resisted quadriceps exercises performed during hospitalization during exacerbation have been shown to improve muscle strength without increasing systemic inflammation. PR that is started within 3 weeks of discharge following a COPD exacerbation reduces hospital admissions, improves quality of life, and also increases exercise capacity when implemented within 8 weeks of discharge. Although the best approach is indistinct and further investigations are necessary, a combination of regular exercise with breathing technique training has been shown to be superior [109].

6.6. PR in the intensive unit care

In the ICU, skeletal muscle mass is lost at a rate of 5% per week. This neuromuscular weakness has been found to be correlated with the duration of mechanical ventilation, and associated with functional disability and decreased quality of life for up to 5 years after hospitalization. Mobilization and rehabilitation of critically ill patients might improve physical functioning and decrease duration of mechanical ventilation and ICU length of stay [110, 111]. A meta-analysis was published in 2017 that consisted of studies with PR programs containing patient mobilization, walking, standing, breathing exercises, in-bed supine cycle ergometry, passive-active range of motion (ROM), and NMES. It was shown that early mobilization and physical rehabilitation of critically ill patients seemed to be safe, with a low risk of potential safety events, even if as a usual care. Although the definition of safety assessments was heterogeneous, it was emphasized that the awareness and implementation of existing recommendations should be increased [112].

6.7. Patients with hypercapnia

Hypercapnia is an indicator of alveolar hypoventilation due to an overload on the ventilatory pump that is greater than its capacity. In patients with COPD, diminished ventilatory response usually results in chronic retention of carbon dioxide. Chronic respiratory failure is frequently seen in the end stage of the progression of COPD. In the BTS guidelines, it is mentioned that patients with chronic respiratory failure gain as much benefit as those without chronic respiratory failure from PR with level 3 evidence [106]. A study showed that pCO2 levels were significantly more reduced in patients with COPD with pursed-lip and diaphragmatic breathing exercises during hospitalization period than in a control group. It was suggested that respiratory exercise training was quite effective in reducing pCO2 levels. As the guidelines recommend, patients with COPD should be referred for PR regardless of having chronic respiratory failure [113].

Noninvasive mechanical ventilation (NIMV): Noninvasive mechanical ventilation (NIMV) reduces breathlessness and increases exercise tolerance by reducing the acute load on the respiratory muscles. According to these mechanisms, the effect of NIMV on PR outcomes has been investigated in several studies in which NIMV was applied during exercise training or at night. In a review of the Cochrane Database in which the effect of NIMV was investigated during exercise training as a part of PR, it was shown that NIMV during exercise training improved exercise capacity of the lower limbs, and enabled exercise at higher training intensities. There was no definite evidence about quality of life and none of the studies investigated the effect of NIMV during exercise training on physical activity [114]. It has also been shown that exercise tolerance and quality of life were improved in patients with severe COPD using nocturnal NIMV after PR, presumably through resting the respiratory muscles at night [115]. As a recommendation of the ERS/ATS guidelines, NIMV could be an adjunctive therapy to unload the respiratory muscles for the purpose of increasing the intensity of exercise training in selected patients with severe chronic respiratory disease who have a suboptimal response to exercise [1].

6.8. Comorbidities

The most common comorbidities associated with COPD are cardiovascular disease, orthopedic problems, metabolic disease, depression, and anxiety. It is expected that comorbidities may effect the outcomes of PR as an impact on COPD outcomes such as quality of life, health care costs, and mortality rate. Various comorbidities such as anxiety and depression, cardiovascular disease, metabolic disease, and osteoporosis affected PR outcomes in some studies [116, 117, 118, 119, 120, 121]; a meta-analysis could not be performed according to the heterogeneous results. Only four studies investigated the influence of the number of comorbidities on PR outcomes. Three of which showed that the number of comorbidities was not related to PR outcomes [117, 119, 120]. A study showed that metabolic disease negatively influenced 6MWT distance, whereas cardiac disease negatively influenced the St. George’s Respiratory Questionnaire [118]. A prior study of patients with COPD with osteoarthritis and neurologic problems who were assigned to water-based exercise training reported a greater improvement in outcomes compared with land-based exercise training [121]. Previous studies have identified that patients with psychiatric problems experienced a lesser improvement in dyspnea [117], and patients with metabolic disease demonstrated a greater improvement in dyspnea after PR compared with controls [118]. A study was published in 2017 that included 165 patients with COPD with exercise limitations. Comorbidity was classified as cardiac, metabolic, orthopedic, behavioral health problems, or other diseases. Comorbidities were found to have no effect on the maximal incremental exercise test and constant workload cycle endurance time after PR. Patients with cardiac disease were found to have greater improvements in dyspnea scores than those with no cardiac disease, and patients with orthopedic problems had a smaller but clinically significant improvement in dyspnea after PR [122]. Modifying PR programs with consideration to comorbidities might lead to greater improvement in outcomes, but how to structure programs according to comorbidities is still to be determined.

7. Follow-up programs of PR and Tele-PR

The best and the most effective follow-up program have not been found. After PR, the important points are to follow prescribed home exercise programs and follow-up programs in the PR center/unit, and to be more active in daily living life for the purpose of preserving improvements. Accordingly, family members have a role that is as important as that of the PR center staff in encouraging and motivating the patients. In a cohort of patients with COPD who completed a 10-week comprehensive PR program, a structured follow-up home program was prescribed and the patients were monitored for 1 year. At the 1-year follow-up evaluation, only the patients who continued with the home program had maintained the improvements of the initial PR program in endurance capacity, and psychological and cognitive functioning [123, 124]. Despite the clear benefits of PR, it is often an under-utilized resource. Limited access and poor adherence result in <5% of eligible people with COPD receiving PR each year. Although the traditional models of inpatient and outpatient PR are suitable for many patients, alternative models may also be effective and may improve patient access, particularly in regions or healthcare systems where traditional models of PR are not feasible. For example, tele-rehabilitation, which links expert rehabilitation healthcare providers with others at a remote site or with patients in their homes, also has the potential to improve access [125]. A recent study showed that home-based maintenance tele-rehabilitation was equally as effective as hospital-based, outpatient, maintenance PR in reducing the risk for acute exacerbations of COPD and hospitalizations with lower risk for emergency department visits. It was suggested that tele-rehabilitation was likely to be an effective alternative strategy to hospital-based, outpatient, maintenance PR. In addition, it had a potential economic advantage compared with standard PR [126]. Tele-PR has been developed to improve patients’ participation and treatment adherence, but the most important point is awareness. The awareness of PR should be increased in patients and among health professionals.


1 - Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, et al. An official American Thoracic Society/European Respiratory Society statement: Key concepts and advances in pulmonary rehabilitation. American Journal of Respiratory and Critical Care Medicine. 2013;188(8):13-64
2 - MacIntyre NR. Mechanisms of functional loss in patients with chronic lung disease. Respiratory Care. 2008;53(9):1177-1184
3 - European Respiratory Society Task Force. Clinical exercise testing with reference to lung diseases: Indications, standardization and interpretation strategies. The European Respiratory Journal. 1997;10(11):2662-2689
4 - Borak J, Chodosowska E, Matuszewski A, Zielinski J. Emotional status does not alter exercise tolerance in patients with chronic obstructive pulmonary disease. The European Respiratory Journal. 1998;12:370-373
5 - Janson C, Bjornsson E, Hetta J, Boman G. Anxiety and depression in relation to respiratory symptoms and asthma. American Journal of Respiratory and Critical Care Medicine. 1994;149:930-934
6 - Parekh PI, Blumenthal JA, Babyak MA, Merrill K, Carney RM, Davis RD, Palmer SM. Psychiatric disorder and quality of life in patients awaiting lung transplantation. Chest. 2003;124:1682-1688
7 - O'Donnell DE. Ventilatory limitations in chronic obstructive pulmonary disease. Medicine and Science in Sports and Exercise. 2001 Jul;33(7 Suppl):S647-S655
8 - Somfay A, Porszasz J, Lee SM, Casaburi R. Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patients. Chest. 2002;121:393-400
9 - Wasserman K, Hansen JE, Sue DY, Stringer W, Whipp BJ. Principles of Exercise Testing and Interpretation. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 41
10 - Weltman A, Wood CM, Womack CJ, Davis SE, Blumer JL, Alvarez J, et al. Catecholamine and blood lactate responses to incremental rowing and running exercise. Journal of Applied Physiology. 1994;76(3):1144-1149
11 - World Health Organization. Definition of chronic corpulmonale. Circulation. 1963;27:594-615
12 - Santos S, Peinado VI, Ramirez J, Melgosa T, Roca J, Rodriguez-Roisin R, Barbera JA. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. The European Respiratory Journal. 2002;19:632-638
13 - Voelkel NF, Tuder RM. Hypoxia-induced pulmonary vascular remodeling: A model for what human disease? The Journal of Clinical Investigation. 2000;106:733-738
14 - Chetty KG, Brown SE, Light RW. Improved exercise tolerance of the polycythemic lung patient following phlebotomy. The American Journal of Medicine. 1983;74:415-420
15 - Sietsema K. Cardiovascular limitations in chronic pulmonary disease. Medicine and Science in Sports and Exercise. 2001;33:S656-S661
16 - Ranieri VM, Dambrosio M, Brienza N. Intrinsic PEEP and cardiopulmonary interaction in patients with COPD and acute ventilatory failure. The European Respiratory Journal. 1996;9:1283-1292
17 - Oswald-Mammosser M, Kessler R, Massard G, et al. Effect of lung volume reduction surgery on gas exchange and pulmonary hemodynamics at rest and during exercise. American Journal of Respiratory and Critical Care Medicine. 1998;158:1020-1025
18 - Mahler DA, Brent BN, Loke J, et al. Right ventricular performance and central circulatory hemodynamics during upright exercise in patients with chronic obstructive pulmonary disease. The American Review of Respiratory Disease. 1984;130:722-729
19 - Miller JD, Pegelow DF, Jacques AJ, et al. Effects of augmented respiratory muscle pressure production on locomotor limb venous return during calf contraction exercise. Journal of Applied Physiology. 2005;99:1802-1815
20 - Oswald-Mammosser M, Apprill M, Bachez P, et al. Pulmonary hemodynamics in chronic obstructive pulmonary disease of the emphysematous type. Respiration. 1991;58:304-310
21 - Montes de Oca M, Rassulo J, Celli BR. Respiratory muscle and cardiopulmonary function during exercise in very severe COPD. American Journal of Respiratory and Critical Care Medicine. 1996;154:1284-1289
22 - MacNee W. Pathophysiology of corpulmonale in chronic obstructive pulmonary disease: Part one. American Journal of Respiratory and Critical Care Medicine. 1994;150:833-852
23 - Kim HC, Mofarrahi M, Hussain NA. Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. International Journal of COPD. 2008;3(4):637-658
24 - Creutzberg EC, Schols AM, Bothmer-Quaedvlieg FC, Wouters EF. Prevalence of an elevated resting energy expenditure in patients with chronic obstructive pulmonary disease in relation to body composition and lung function. European Journal of Clinical Nutrition. 1998;52:396-401
25 - Choudhury G, Rabinovich R, MacNee W. Comorbidities and systemic effects of chronic obstructive pulmonary disease. Clinics in Chest Medicine. 2014;35:101-130
26 - Schols AM, Broekhuizen R, Weling-Scheepers CA, Wouters EF. Body composition and mortality in chronic obstructive pulmonary disease. The American Journal of Clinical Nutrition. 2005;82:53-59
27 - Vermeeren MA, Creutzberg EC, Schols AM, et al. Prevalence of nutritional depletion in a large out-patient population of patients with COPD. Respiratory Medicine. 2006;100:1349-1355
28 - Agusti AG. Systemic effects of chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2005;2:367-370 discussion 371-372
29 - Vermeeren MA, Wouters EF, Geraerts-Keeris AJ, Schols AM. Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial. Clinical Nutrition. 2004;23:1184-1192
30 - Brug J, Schols A, Mesters I. Dietary change, nutrition education and chronic obstructive pulmonary disease. Patient Education and Counseling. 2004;52:249-257
31 - Creutzberg EC, Wouters EF, Mostert R, et al. Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease. Nutrition. 2003;19:120-127
32 - Sehgal S, Dhooria S, Agarwal R. Chronic obstructive pulmonary disease and malnutrition in developing countries. Current Opinion in Pulmonary Medicine. 2017;23:139-148
33 - Hynninen KM, Breitve MH, Wiborg AB, et al. Psychological characteristics of patients with chronic obstructive pulmonary disease: A review. Journal of Psychosomatic Research. 2005;59:429-443
34 - Atlantis E, Fahey P, Cochrane B, et al. Bidirectional associations between clinically relevant depression or anxiety and COPD: A systematic review and meta-analysis. Chest. 2013;144:766-777
35 - Glassman AH, Helzer JE, Covey LS, et al. Smoking, smoking cessation, and major depression. JAMA. 1990;264:1546-1549
36 - Fergusson DM, Lynskey MT, Horwood LJ. Comorbidity between depressive disorders and nicotine dependence in a cohort of 16-year-olds. Archives of General Psychiatry. 1996;53:1043-1047
37 - Patton GC, Hibbert M, Rosier MJ, et al. Is smoking associated with depression and anxiety in teenagers? American Journal of Public Health. 1996;86:225-230
38 - Glassman AH, Covey LS, Stetner F, et al. Smoking cessation and the course of major depression: A follow-up study. Lancet. 2001;357:1929-1932
39 - Wiesbeck GA, Kuhl HC, Yaldizli O, et al. Tobacco smoking and depression--results from the WHO/ISBRA study. Neuropsychobiology. 2008;57:26-31
40 - Mineur YS, Picciotto MR. Nicotine receptors and depression: Revisiting and revising the cholinergic hypothesis. Trends in Pharmacological Sciences. 2010;31:580-586
41 - Sinden NJ, Stockley RA. Systemic inflammation and comorbidity in COPD: A result of ‘overspill’ of inflammatory mediators from the lungs? Review of the evidence. Thorax. 2010;65:930-936
42 - Eagan TM, Ueland T, Wagner PD, et al. Systemic inflammatory markers in COPD: Results from the Bergen COPD cohort study. The European Respiratory Journal. 2010;35:540-548
43 - Al-shair K, Kolsum U, Dockry R, et al. Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD. Respiratory Research. 2011;12:3
44 - Marinho PE, Castro CM, Raposo MC, et al. Depressive symptoms, inflammatory markers and body composition in elderly with and without chronic obstructive pulmonary disease (COPD). Archives of Gerontology and Geriatrics. 2012;54:453-458
45 - van Dijk EJ, Vermeer SE, de Groot JC, et al. Arterial oxygen saturation, COPD, and cerebral small vessel disease. Journal of Neurology, Neurosurgery, and Psychiatry 2004;75:733-736.
46 - Campbell JJ 3rd, Coffey CE. Neuropsychiatric significance of subcortical hyperintensity. The Journal of Neuropsychiatry and Clinical Neurosciences. 2001;13:261-288
47 - Dunlop DD, Lyons JS, Manheim LM, et al. Arthritis and heart disease as risk factors for major depression: The role of functional limitation. Medical Care. 2004;42:502-511
48 - Penninx BW, van Tilburg T, Boeke AJ, et al. Effects of social support and personal coping resources on depressive symptoms: Different for various chronic diseases? Health Psychology 1998;17:551-558
49 - Emery CF, Leatherman NE, Burker EJ, MacIntyre NR. Psychological outcomes of a pulmonary rehabilitation program. Chest. 1991;100:613-617
50 - Emery CF, Schein RL, Hauck ER, MacIntyre NR. Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease. Health Psychology. 1998;17:232-240
51 - O’Donnell DE, McGuire M, Samis L, Webb KA. The impact of exercise reconditioning on breathlessness in severe chronic airflow limitation. American Journal of Respiratory and Critical Care Medicine. 1995;152:2005-2013
52 - Garvey C, Bayles MP, Hamm LF, Hill K, Holland A, Limberg TM, Spruit MA. Pulmonary rehabilitation exercise prescription in chronic obstructive pulmonary disease: Review of selected guidelines. Journal of Cardiopulmonary Rehabilitation and Prevention. 2016;36:75-83
53 - Mota S, Güell R, Barreiro E, Solanes I, Ramírez-Sarmiento A, OrozcoLevi M, et al. Clinical outcomes of expiratory muscle training in severe COPD patients. Respiratory Medicine. 2007;101(3):516-524
54 - Weiner P, McConnell A. Respiratory muscle training in chronic obstructive pulmonary disease: Inspiratory, expiratory, or both? Current Opinion in Pulmonary Medicine. 2005;11(2):140-144
55 - Ramirez-Sarmiento A, Orozco-Levi M, Guell R, et al. Inspiratory muscle training in patients with chronic obstructive pulmonary disease: Structural adaptation and physiologic outcomes. American Journal of Respiratory and Critical Care Medicine. 2002;166(11):1491-1497
56 - Villafranca C, Borzone G, Leiva A, et al. Effect of inspiratory muscle training with an intermediate load on inspiratory power output in COPD. The European Respiratory Journal. 1998;11(1):28-33
57 - O’Donnell DE, Webb KA. Exertional breathlessness in patients with chronic airflow limitation. The American Review of Respiratory Disease. 1993;148(5):1351-1357
58 - Mador MJ, Deniz O, Aggarwal A, et al. Effect of respiratory muscle endurance training in patients with COPD undergoing pulmonary rehabilitation. Chest. 2005;128(3):1216-1224
59 - Larson JL, Covey MK, Wirtz SE, et al. Cycle ergometer and inspiratory muscle training in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 1999;160(2):500-507
60 - Chen R, Li X, Guan N, Guo B, Wu W, Zhou Z, Huo Y, Chen X, Zhou L. Effectiveness of neuromuscular electrical stimulation for the rehabilitation of moderate-to-severe COPD: A meta-analysis. Intl J COPD. 2016;11:2965-2975
61 - Abdellaoui A, Préfaut C, Gouzi F, Couillard A, Coisy-Quivy M, Hugon G, Molinari N, Lafontaine T, Jonquet O, Laoudj-Chenivesse D, et al. Skeletal muscle effects of electrostimulation after COPD exacerbation: A pilot study. The European Respiratory Journal. 2011;38:781-788
62 - Dal Corso S, Nápolis L, Malaguti C, Gimenes AC, Albuquerque A, Nogueira CR, De Fuccio MB, Pereira RD, Bulle A, McFarlane N, et al. Skeletal muscle structure and function in response to electrical stimulation in moderately impaired COPD patients. Respiratory Medicine. 2007;101:1236-1243
63 - McNamara RJ, McKeough ZJ, McKenzie DK, Alison JA. Water-based exercise in COPD with physical comorbidities: A randomised controlled trial. The European Respiratory Journal. 2013;41(6):1284-1291
64 - Leung RW, McKeough ZJ, Peters MJ, Alison JA. Short-form sun-style t’ai chi as an exercise training modality in people with COPD. The European Respiratory Journal. 2013;41(5):1051-1057
65 - Yan JH, Guo YZ, Yao HM, Pan L. Effects of tai chi in patients with chronic obstructive pulmonary disease: Preliminary evidence. PLoS One. 2013;8(4) e61806
66 - Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM. Global burden of COPD: Systematic review and meta-analysis. The European Respiratory Journal. 2006;28:523-532
67 - Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet. 2012;379:1341-1351
68 - McCarthy B, Casey D, Devane D, Murphy K, Murphy E, Lacasse Y. Pulmonary rehabilitation for chronic obstructive pulmonary disease (review). Cochrane Database of Systematic Reviews. 2015;(2). DOI: 10.1002/14651858.CD003793.pub3
69 - The Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017.
70 - Evans RA, Singh SJ, Collier R, Williams JE, Morgan MD. Pulmonary rehabilitation is successful for COPD irrespective of MRC dyspnoea grade. Respiratory Medicine. 2009;103:1070-1075
71 - Puente-Maestu L, Palange P, Casaburi R, Laveneziana P, Maltais F, Neder J, O’Donnell DE,Onorati P, Porszasz J, Rabinovich R, Rossiter HB, Singh S, Troosters T, Ward S. Use of exercise testing in the evaluation of interventional efficacy: An official ERS statement. The European Respiratory Journal. 2016;47:429-460
72 - Ringbaek T, Martinez G, Brøndum E, et al. Shuttle walking test as predictor of survival in chronic obstructive pulmonary disease patients enrolled in a rehabilitation program. Journal of Cardiopulmonary Rehabilitation and Prevention. 2010;30:409-414
73 - Steiner MC, Singh SJ, Morgan MD. The contribution of peripheral muscle function to shuttle walking performance in patients with chronic obstructive pulmonary disease. Journal of Cardiopulmonary Rehabilitation. 2005;25:43-49
74 - Lacasse Y, Wong E, Guyatt GH, et al. Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease. Lancet. 1996;348:1115-1119
75 - Wasserman K, Hansen JE, Sue DY, et al. Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2011
76 - Puhan MA, Chandra D, Mosenifar Z, et al. The minimal important difference of exercise tests in severe COPD. The European Respiratory Journal. 2011;37:784-790
77 - Corhay JL, Nguyen D, Duysinx B, et al. Should we exclude elderly patients with chronic obstructive pulmonary disease from a long-time ambulatory pulmonary rehabilitation programme? Journal of Rehabilitation Medicine. 2012;44:466-472
78 - Troosters T, Casaburi R, Gosselink R, et al. Pulmonary rehabilitation in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2005;172:19-38
79 - Smid MSc E, Franssen F, Houben-Wilke S, Vanfleteren L, Janssen D, Wouters E, Spruit M. Responsiveness and MCID estimates for CAT, CCQ, and HADS in patients with COPD undergoing pulmonary rehabilitation: A prospective analysis. JAMDA. 2017;18:53e58
80 - Langer D. Rehabilitation in patients before and after lung transplantation. Respiration. 2015;89:353-362
81 - Wickerson L, Mathur S, Brooks D. Exercise training after lung transplantation: A systematic review. The Journal of Heart and Lung Transplantation. 2010;29:497-503
82 - Takaoka ST, Weinacker AB. The value of preoperative pulmonary rehabilitation. Thoracic Surgery Clinics. 2005;15:203-211
83 - Costache V, Chavanon O, St Raymond C, et al. Dramatic improvement in survival after lung transplantation over time: A single center experience. Transplantation Proceedings. 2009;41:687-691
84 - Troosters T, Demeyer H, Hornikx M, et al. Pulmonary rehabilitation. Clinics in Chest Medicine. 2014;35:241-249
85 - Van der Woude BT, Kropmans TJB, Douma KW, et al. Peripheral muscle force and exercise capacity in lung transplant candidates. International Journal of Rehabilitation Research. 2002;25:351-355
86 - Mathur S, Reid WD, Levy RD. Exercise limitation in recipients of lung transplants. Physical Therapy. 2004;84:1178-1187
87 - Wang XN, Williams TJ, McKenna MJ, Li JL, Fraser SF, Side EA, et al. Skeletal muscle oxidative capacity, fiber type, and metabolites after lung transplantation. American Journal of Respiratory and Critical Care Medicine. 1999;160(1):57
88 - Krieger AC, Szidon P, Kesten S. Skeletal muscle dysfunction in lung transplantation. The Journal of Heart and Lung Transplantation. 2000;19:392-400
89 - Pantoja JG, Andrade FH, Stokic DS, Frost AE, Eschenbacher WL, Reid MB. Respiratory and limb muscle function in lung allograft recipients. American Journal of Respiratory and Critical Care Medicine. 1999;160:1205-1211
90 - Williams TJ, Patterson GA, McClean PA, Zamel N, Maurer JR. Maximal exercise testing in single and double lung transplant recipients. The American Review of Respiratory Disease. 1992;145(1):101-105
91 - Lands LC, Smountas AA, Mesiano G, Brosseau L, Shennib H, Charbonneau M, Gauthier R.Maximal exercise capacity and peripheral skeletal muscle function following lung transplantation. The Journal of Heart and Lung Transplantation. 1999;18(2):113-120
92 - Schuurmans MM, Benden C, Inci I. Practical approach to early postoperative management of lung transplant recipients. Swiss Medical Weekly. 2013;143:137-173
93 - Downs AM. Physical therapy in lung transplantation. Physical Therapy. 1996;76(6):626-642
94 - National Emphysema Treatment Trial Group. A randomized trial comparing lung volume-reduction surgery with medical therapy for severe emphysema. The New England Journal of Medicine. 2003;348(21):2059-2073
95 - Pompeo E, Marino M, Nofroni I, Matteucci G, Mineo TC. Reduction pneumoplasty versus respiratory rehabilitation in severe emphyse- ma: A randomized study. The Annals of Thoracic Surgery. 2000;70(3):948-954
96 - Criner GJ, Cordova FC, Furukawa S, Kuzma AM, Travaline JM, Leyenson V, O’Brien GM.Prospective randomized trial comparing bilateral lung volume reduction surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 1999;160(6):2018-2027
97 - Koegelenberg CF, Theron J, Dheda K, Bruwer JW, Allwood BW, Vorster J, Groote-Bidlingmaier F, Slebos DJ, Shah PL, Herth FJF. Recommendations for the use of endoscopic lung volume reduction in South Africa: Role in the treatment of emphysema. SAMJ. 2015;105:810-815
98 - Gao K, PM Y, JH S, He CQ, Liu LX, Zhou YB, Pu Q, Che GW. Cardiopulmonary exercise testing screening and pre-operative pulmonary rehabilitation reduce postoperative complications and improve fast-track recovery after lung cancer surgery: A study for 342 cases. Thorac Cancer. 2015 Jul;6(4):443-449
99 - Adamsen L, Midtgaard J, Andersen C, Quist M, Moeller T, Roerth M. Transforming the nature of fatigue through exercise: Qualitative findings from a multidimensional exercise programme in cancer patients undergoing chemotherapy. European Journal of Cancer Care. 2004;13(4):362-370
100 - Pasqua F, D'Angelillo R, Mattei F, et al. Pulmonary rehabilitation following radical chemoradiation in locally advanced non surgical NSCLC: Preliminary evidences. Lung Cancer. 2012;76(2):258-259
101 - Tarumi S, Yokomise H, Gotoh M, et al. Pulmonary rehabilitation during induction chemoradiotherapy for lung cancer improves pulmonary function. Journal of Thoracic and Cardiovascular Surgery. 2015;149(2):569-573
102 - Keays KS, Harris SR, Lucyshyn JM, MacIntyre DL. Effects of pilates exercises on shoulder range of motion, pain, mood, and upper extremity function in women living with breast cancer: A pilot study. Physical Therapy. 2008;88(4):494-510
103 - Clay CA, Perera S, Wagner JM, Miller ME, Nelson JB, Grrenspan SL. Physical function in men with prostate cancer on androgen deprivation therapy. Physical Therapy. 2007;87(10):1325-1333
104 - Bicego D, Brown K, Ruddick M, Storey D, Wong C, Harris SR. Exercise for women with or at risk for breast cancer-related lymphedema. Physical Therapy. 2006;86(10):1398-13405
105 - Albrecht TA, Taylor AG. Physical activity in patients with advanced-stage cancer: A systematic review of the literature. Clinical Journal of Oncology Nursing. 2012;16(3):293-300
106 - Bolton CE, Bevan- Smith EF, Blakey JD, et al. British Thoracic Society guideline on pulmonary rehabilitation in adults. Thorax. 2013;68:1-30
107 - Puhan M, Scharplatz M, Troosters T, Walters EH, Steurer J. Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2011;1:5305
108 - Lacasse Y, Goldstein R, Lasserson TJ, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews. 2006;4:37-93
109 - Wedzicha JA, Miravitlles M, Hurst JR, Calverley P, Albert K, Anzueto A, Criner J, Papi A, Rabe KF, Rigau D, Sliwinski P, Tonia T, Vestbo J, Wilson KC, Krishnan JA. Management of COPD exacerbations: A European Respiratory Society/American Thoracic Society guideline. The European Respiratory Journal. 2017;49:1600791
110 - Ntoumenopoulos G. Rehabilitation during mechanical ventilation: Review of the recent literature. Intensive & Critical Care Nursing. 2015;31(3):125-132
111 - Sommers J, Engelbert RHH, Dettling-Ihnenfeldt D, Gosselink R, Spronk PE, Nollet F, van der Schaaf M. Physiotherapy in the intensive care unit: An evidence-based, expert driven, practical statement and rehabilitation recommendations. Clinical Rehabilitation 2015;29(11):1051-1063
112 - Nydahl P, Sricharoenchai T, Chandra S, Kundt FS, Huang M, Fischill M, Needham DM.Safety of patient mobilization and rehabilitation in the intensive care unit. Systematic review with meta-analysis. Annals of the American Thoracic Society. 2017 May;14(5):766-777
113 - Hoff J, Tjonna AE, Steinshamn S, et al. Maximal strength training of the legs in COPD: A therapy for mechanical inefficiency. Medicine and Science in Sports and Exercise. 2007;39:220-226
114 - Menadue C, Piper AJ, van ‘t Hul AJ, Wong KK. Non-invasive ventilation during exercise training for people with chronic obstructive pulmonary disease (review). Cochrane Data base of Systematic Reviews. 2014(5). Art. No.: CD007714
115 - Garrod R, Mikelsons C, Paul EA, Wedzicha JA. Randomized controlled trial of domiciliary noninvasive positive pressure ventilation and physical training in severe chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 2000;162:1335-1341
116 - Hornikx M, Van Remoortel H, Demeyer H, et al. The influence of comorbidities on outcomes of pulmonary rehabilitation pro- grams in patients with COPD: A systematic review. BioMed Research International. 2013;2013:146-148
117 - Carreiro A, Santos J, Rodrigues F. Impact of comorbidities in pulmonary rehabilitation outcomes in patients with chronic obstructive pulmonary disease. Revista Portuguesa de Pneumologia. 2013;19(3):106-113
118 - Crisafulli E, Costi S, Luppi F, et al. Role of comorbidities in a cohort of patients with COPD undergoing pulmonary rehabilitation. Thorax. 2008;63:487-492
119 - Crisafulli E, Gorgone P, Vagaggini B, et al. Efficacy of standard rehabilitation in COPD outpatients with comorbidities. European Respiratory Journal. 2010;36:1042-1048
120 - Walsh JR, McKeough ZJ, Morris NR, et al. Metabolic disease and participant age are independent predictors of response to pulmonary rehabilitation. Journal of Cardiopulmonary Rehabilitation and Prevention. 2013;33:249-256
121 - McNamara RJ, McKeough ZJ, McKenzie DK, Alison JA. Water- based exercise in COPD with physical comorbidities: A ran- domised controlled trial. European Respiratory Journal. 2013;41:1284-1291
122 - Tunsupon P, Lal A, Khamis MA, Mador MJ. Comorbidities in patients with chronic obstructive pulmonary disease and pulmonary rehabilitation outcomes. Journal of Cardiopulmonary Rehabilitation and Prevention. 2017;00:1-9
123 - Emery CF, Shermer RL, Hauck ER, Hsiao ET, MacIntyre NR. Cognitive and psychological outcomes of exercise in a 1-year follow-up study of patients with chronic obstructive pulmonary disease. Health Psychology. 2003;22(6):598-604
124 - Corhay J, Dang DN, Cauwenberge H, Louis R. Pulmonary rehabilitation and COPD: Providing patients a good environment for optimizing therapy. International Journal of COPD. 2014;9:27-39
125 - Rochester CL, Vogiatzis I, Holland AE, Lareau SC, Marciniuk DD, Puhan MA, et al. An official American Thoracic Society/European Respiratory Society policy statement: Enhancing implementation, use, and delivery of pulmonary rehabilitation. American Journal of Respiratory and Critical Care Medicine. 2015;192(11):1373-1386
126 - Vasilopoulou M, Papaioannou AI, Kaltsakas G, et al. Home-based maintenance tele-rehabilitation reduces the risk for acute exacerbations of COPD, hospitalisations and emergency department visits. The European Respiratory Journal. 2017;49:1602129