Biochemistry, Genetics and Molecular Biology

Protein-Protein Interactions - Computational and Experimental Tools

Edited by Weibo Cai and Hao Hong, ISBN 978-953-51-0397-4, 484 pages, Publisher: InTech, Chapters published March 30, 2012 under CC BY 3.0 license
DOI: 10.5772/2679
Edited Volume

Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

  • Thomson Reuters' Book Citation Index
  • badge

This book is indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI), BIOSIS Previews, and The Zoological Record. BKCI is part of the Web of Science Core Collection (WoSCC) together with SCI Expanded, SSCI, AHCI and other databases.

CITED BY:
25 ARTICLES
  1. The Interaction of CRM1 and the Nuclear Pore Protein Tpr
    Charles L. Zhao, Seyed Hanif Mahboobi, Ruhollah Moussavi-Baygi, Mohammad R. K. Mofrad and Michael Massiah
    Crossref
  2. Predicted binding site information improves model ranking in protein docking using experimental and computer-generated target structures
    Surabhi Maheshwari and Michal Brylinski
    Crossref
  3. Effect of pH and ionic strength on the binding strength of anti-PF4/polyanion antibodies
    Thi-Huong Nguyen and Andreas Greinacher
    Crossref
  4. Polypyrrole as an Efficient Solid-Phase Extraction Sorbent for Determination of Chloramphenicol Residue in Chicken Liver, Kidney, and Meat
    Zahra Rahimi, Yasser Shahbazi and Farhad Ahmadi
    Crossref
  5. Charged patchy particle models in explicit salt: Ion distributions, electrostatic potentials, and effective interactions
    Cemil Yigit, Jan Heyda and Joachim Dzubiella
    Crossref
  6. Lytic enzymes of staphylococcal phages: Correlation between secondary structure and stability
    L. Y. Filatova, D. M. Donovan, J. A. Foster-Frey, V. G. Pugachev, E. V. Kudryashova and N. L. Klyachko
    Crossref
  7. Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity
    Jayant Arora, Yue Hu, Reza Esfandiary, Hasige A. Sathish, Steven M. Bishop, Sangeeta B. Joshi, C. Russell Middaugh, David B. Volkin and David D. Weis
    Crossref
  8. Characterization of crude ovomucins obtained from various egg white layers
    Jaakko Hiidenhovi, Christine Ek-Kommonen, Eila Järvenpää, Rainer Huopalahti and Eeva-Liisa Ryhänen
    Crossref
  9. Recent Developments and Applications of Three-Phase Partitioning for the Recovery of Proteins
    Kit Wayne Chew, Tau Chuan Ling and Pau Loke Show
    Crossref
  10. A crystallization apparatus for temperature-controlled flow-cell dialysis with real-time visualization
    Niels Junius, Esko Oksanen, Maxime Terrien, Christophe Berzin, Jean-Luc Ferrer and Monika Budayova-Spano
    Crossref
  11. Liquid-liquid extraction of protease from cold-adapted yeastRhodotorula mucilaginosaL7 using biocompatible and biodegradable aqueous two-phase systems
    Luciana Daniela Lario, Luciana Pellegrini Malpiedi, Jorge Fernando Brandão Pereira, Lara Durães Sette and Adalberto Pessoa-Junior
    Crossref
  12. Mapping the mAb aggregation propensity using self-interaction chromatography as a screening tool
    Sarah Hedberg, DongKyu Lee, Yash Mishra, Jonathan Haigh and Daryl R Williams
    Crossref
  13. UnityMol: interactive and ludic visual manipulation of coarse-grained RNA and other biomolecules
    Sebastien Doutreligne, Cedric Gageat, Tristan Cragnolini, Antoine Taly, Samuela Pasquali, Philippe Derreumaux and Marc Baaden
    Crossref
  14. Touch-less interactive augmented reality game on vision-based wearable device
    Zhihan Lv, Alaa Halawani, Shengzhong Feng, Shafiq ur Réhman and Haibo Li
    Crossref
  15. Serious game based dysphonic rehabilitation tool
    Zhihan Lv, Chantal Esteve, Javier Chirivella and Pablo Gagliardo
    Crossref
  16. Innovative interactive flexible docking method for multi-scale reconstruction elucidates dystrophin molecular assembly
    A.-E. Molza, N. Férey, M. Czjzek, E. Le Rumeur, J.-F. Hubert, A. Tek, B. Laurent, M. Baaden and O. Delalande
    Crossref
  17. Virtual geographic environment based coach passenger flow forecasting
    Zhihan Lv, Xiaoming Li, Jinxing Hu, Ling Yin, Baoyun Zhang and Shengzhong Feng
    Crossref
  18. A game based assistive tool for rehabilitation of dysphonic patients
    Zhihan Lv, Chantal Esteve, Javier Chirivella and Pablo Gagliardo
    Crossref
  19. Traffic Management and Forecasting System Based on 3D GIS
    Xiaoming Li, Zhihan Lv, Jinxing Hu, Baoyun Zhang, Ling Yin, Chen Zhong, Weixi Wang and Shengzhong Feng
    Crossref
  20. Extending touch-less interaction on vision based wearable device
    Zhihan Lv, Shengzhong Feng, Liangbing Feng and Haibo Li
    Crossref
  21. Enhancing visualization of molecular simulations using sonification
    Benjamin Rau, Florian Friess, Michael Krone, Christoph Muller and Thomas Ertl
    Crossref
  22. XEarth: A 3D GIS platform for managing massive city information
    Xiaoming Li, Zhihan Lv, Jinxing Hu, Baoyun Zhang, LingYan Shi and Shengzhong Feng
    Crossref
  23. Imagining in-air interaction for hemiplegia sufferer
    Zhihan Lv and Haibo Li
    Crossref
  24. Identification of drug-target modules in the human protein–protein interaction network
    Takeshi Hase, Kaito Kikuchi, Samik Ghosh, Hiroaki Kitano and Hiroshi Tanaka
    Crossref
  25. BINESA — A software tool for evolution modelling of biochemical networks' structure
    Tatjana Rubina and Egils Stalidzans
    Crossref