Chronic Lymphocytic Leukemia

Pablo Oppezzo

doi:10.5772/1156

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Open access peer-reviewed Edited Volume

Chronic Lymphocytic Leukemia

Edited by Pablo Oppezzo

Institut Pasteur, France

B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.

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Chronic Lymphocytic LeukemiaEdited by Pablo Oppezzo

Published: February 10th 2012

DOI: 10.5772/1156

ISBN: 978-953-307-881-6

eBook (PDF) ISBN: 978-953-51-6746-4

Books open for chapter submissions

41248 Total Chapter Downloads

7 Crossref Citations

13 Web of Science Citations

18 Dimensions Citations

chapters		Downloads
Open access peer-reviewed 1. Selected Topics in Chronic Lymphocytic Leukemia Pathogenesis By Sergio Bianchi, Guillermo Dighiero and Otto Pritsch		1769
Open access peer-reviewed 2. Microenvironment Interactions in Chronic Lymphocytic Leukemia: A Delicate Equilibrium Linking the Quiescent and the Proliferative Pool By F. Palacios, C. Abreu, P. Moreno, M. Giordano, R. Gamberale and P. Oppezzo		2189
Open access peer-reviewed 3. Dysregulation of Apoptosis and Proliferation in CLL Cells By Marcin Wójtowicz and Dariusz Wołowiec		1548
Open access peer-reviewed 4. DNA Damage Response/Signaling and Genome (In)Stability as the New Reliable Biological Parameters Defining Clinical Feature of CLL By Jozo Delic, Jean-Brice Marteau, Karim Maloum, Florence Nguyen-Khac, Frédéric Davi, Zahia Azgui, Véronique Leblond, Jacques-Louis Binet, Sylvie Chevillard and Hélène Merle-Béral		1363
Open access peer-reviewed 5. Current Knowledge of Microarray Analysis for Gene Expression Profiling in Chronic Lymphocytic Leukemia By Ida Franiak-Pietryga and Marek Mirowski		1545
Open access peer-reviewed 6. Contribution of microRNAs to CLL Biology and Their Potential as New Biomarkers By Maria Rosa Garcia-Silva, Maria Catalina Güida and Alfonso Cayota		1499
Open access peer-reviewed 7. The Biological Relevance of ZAP-70 in CLL By Valerie Pede, Ans Rombout, Bruno Verhasselt and Jan Philippé		2356
Open access peer-reviewed 8. Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia By John C. Allen and Joseph R. Slupsky		1338
Open access peer-reviewed 9. The Role of Polymorphisms in Co-Signalling Molecules’ Genes in Susceptibility to B-Cell Chronic Lymphocytic Leukaemia By Lidia Karabon and Irena Frydecka		2016
Open access peer-reviewed 10. Mouse Models of Chronic Lymphocytic Leukemia By Gema Pérez-Chacón and Juan M. Zapata		3821
Open access peer-reviewed 11. Altering microRNA miR15a/16 Levels as Potential Therapy in CLL: Extrapolating from the De Novo NZB Mouse Model By Siddha Kasar, Yao Yuan, Chingiz Underbayev, Dan Vollenweider, Matt Hanlon, Victor Chang, Hina Khan and Elizabeth Raveche		1456
Open access peer-reviewed 12. Prognostic Factors in Chronic Lymphoid Leukemia and Identification of New Clinically Relevant Molecular Markers By José-Ángel Hernández, Marcos González and Jesús-María Hernández		1550
Open access peer-reviewed 13. Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance By N. Put, I. Wlodarska, P. Vandenberghe and L. Michaux		2978
Open access peer-reviewed 14. Immune Response and Immunotherapy in Chronic Lymphocytic Leukemia By Leticia Huergo-Zapico, Ana P. Gonzalez-Rodríguez, Juan Contesti, Azahara Fernández-Guizán, Andrea Acebes Huerta, Alejandro López-Soto and Segundo Gonzalez		2153
Open access peer-reviewed 15. In Vitro Sensitivity Testing in the Assessment of Anti-CLL Drug Candidates By Günter Krause, Mirjam Kuckertz, Susan Kerwien, Michaela Patz and Michael Hallek		1796
Open access peer-reviewed 16. Interactions of the Platinum(II) Complexes with Nitrogen- and Sulfur-Bonding Bio-Molecules in Chronic Lymphocytic Leukemia By Jovana Bogojeski, Biljana Petrović and Živadin D. Bugarčić		4118
Open access peer-reviewed 17. Infectious Diseases and Clinical Complications During Treatment in CLL By Farhad Abbasi		2530
Open access peer-reviewed 18. Emerging Therapies in Chronic Lymphocytic Leukemia By Reslan Lina and Dumontet Charles		1604
Open access peer-reviewed 19. Heat Shock Proteins in Chronic Lymphocytic Leukaemia By Nina C. Dempsey-Hibbert, Christine Hoyle and John H.H. Williams		1553
Open access peer-reviewed 20. Present and Future Application of Nanoparticle Based Therapies in B-Chronic Lymphocytic Leukemia (B-CLL) By Eduardo Mansilla, Gustavo H. Marin, Luis Núñez, Gustavo Larsen, Nelly Mezzaroba and Paolo Macor		2066

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