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Open access peer-reviewed Edited Volume

Chronic Lymphocytic Leukemia

Edited by Pablo Oppezzo

Institut Pasteur, France

B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.

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Chronic Lymphocytic LeukemiaEdited by Pablo Oppezzo

Published: February 10th 2012

DOI: 10.5772/1156

ISBN: 978-953-307-881-6

Copyright year: 2012

Books open for chapter submissions

37861 Total Chapter Downloads

5 Crossref Citations

9 Web of Science Citations

16 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Selected Topics in Chronic Lymphocytic Leukemia Pathogenesis

By Sergio Bianchi, Guillermo Dighiero and Otto Pritsch

1598

Open access peer-reviewed

2. Microenvironment Interactions in Chronic Lymphocytic Leukemia: A Delicate Equilibrium Linking the Quiescent and the Proliferative Pool

By F. Palacios, C. Abreu, P. Moreno, M. Giordano, R. Gamberale and P. Oppezzo

2045

Open access peer-reviewed

3. Dysregulation of Apoptosis and Proliferation in CLL Cells

By Marcin Wójtowicz and Dariusz Wołowiec

1416

Open access peer-reviewed

4. DNA Damage Response/Signaling and Genome (In)Stability as the New Reliable Biological Parameters Defining Clinical Feature of CLL

By Jozo Delic, Jean-Brice Marteau, Karim Maloum, Florence Nguyen-Khac, Frédéric Davi, Zahia Azgui, Véronique Leblond, Jacques-Louis Binet, Sylvie Chevillard and Hélène Merle-Béral

1189

Open access peer-reviewed

5. Current Knowledge of Microarray Analysis for Gene Expression Profiling in Chronic Lymphocytic Leukemia

By Ida Franiak-Pietryga and Marek Mirowski

1397

Open access peer-reviewed

6. Contribution of microRNAs to CLL Biology and Their Potential as New Biomarkers

By Maria Rosa Garcia-Silva, Maria Catalina Güida and Alfonso Cayota

1365

Open access peer-reviewed

7. The Biological Relevance of ZAP-70 in CLL

By Valerie Pede, Ans Rombout, Bruno Verhasselt and Jan Philippé

2179

Open access peer-reviewed

8. Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia

By John C. Allen and Joseph R. Slupsky

1168

Open access peer-reviewed

9. The Role of Polymorphisms in Co-Signalling Molecules’ Genes in Susceptibility to B-Cell Chronic Lymphocytic Leukaemia

By Lidia Karabon and Irena Frydecka

1863

Open access peer-reviewed

10. Mouse Models of Chronic Lymphocytic Leukemia

By Gema Pérez-Chacón and Juan M. Zapata

3591

Open access peer-reviewed

11. Altering microRNA miR15a/16 Levels as Potential Therapy in CLL: Extrapolating from the De Novo NZB Mouse Model

By Siddha Kasar, Yao Yuan, Chingiz Underbayev, Dan Vollenweider, Matt Hanlon, Victor Chang, Hina Khan and Elizabeth Raveche

1293

Open access peer-reviewed

12. Prognostic Factors in Chronic Lymphoid Leukemia and Identification of New Clinically Relevant Molecular Markers

By José-Ángel Hernández, Marcos González and Jesús-María Hernández

1379

Open access peer-reviewed

13. Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance

By N. Put, I. Wlodarska, P. Vandenberghe and L. Michaux

2760

Open access peer-reviewed

14. Immune Response and Immunotherapy in Chronic Lymphocytic Leukemia

By Leticia Huergo-Zapico, Ana P. Gonzalez-Rodríguez, Juan Contesti, Azahara Fernández-Guizán, Andrea Acebes Huerta, Alejandro López-Soto and Segundo Gonzalez

1982

Open access peer-reviewed

15. In Vitro Sensitivity Testing in the Assessment of Anti-CLL Drug Candidates

By Günter Krause, Mirjam Kuckertz, Susan Kerwien, Michaela Patz and Michael Hallek

1595

Open access peer-reviewed

16. Interactions of the Platinum(II) Complexes with Nitrogen- and Sulfur-Bonding Bio-Molecules in Chronic Lymphocytic Leukemia

By Jovana Bogojeski, Biljana Petrović and Živadin D. Bugarčić

3932

Open access peer-reviewed

17. Infectious Diseases and Clinical Complications During Treatment in CLL

By Farhad Abbasi

2355

Open access peer-reviewed

18. Emerging Therapies in Chronic Lymphocytic Leukemia

By Reslan Lina and Dumontet Charles

1438

Open access peer-reviewed

19. Heat Shock Proteins in Chronic Lymphocytic Leukaemia

By Nina C. Dempsey-Hibbert, Christine Hoyle and John H.H. Williams

1406

Open access peer-reviewed

20. Present and Future Application of Nanoparticle Based Therapies in B-Chronic Lymphocytic Leukemia (B-CLL)

By Eduardo Mansilla, Gustavo H. Marin, Luis Núñez, Gustavo Larsen, Nelly Mezzaroba and Paolo Macor

1910

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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