Open access peer-reviewed Edited Volume

Chromatin and Epigenetics

Edited by

Colin Logie

Radboud University Nijmegen, Netherlands

Tobias Aurelius Knoch

Erasmus University Medical Center, Netherlands

Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general.

Read more >Order hardcopy
Chromatin and EpigeneticsEdited by Colin Logie and Tobias Aurelius Knoch

Published: January 29th 2020

DOI: 10.5772/intechopen.71387

ISBN: 978-1-78984-493-1

Print ISBN: 978-1-78984-492-4

eBook (PDF) ISBN: 978-1-78984-982-0

Copyright year: 2020

Books open for chapter submissions

5841 Total Chapter Downloads

1 Crossref Citations

3 Dimensions Citations


Open access peer-reviewed

1. Logic of Epigenetics and Investigation of Potential Gene Regions

By Metin Budak


Open access peer-reviewed

2. Recognition of Nucleosomes by Chromatin Factors: Lessons from Data-Driven Docking-Based Structures of Nucleosome-Protein Complexes

By Velten Horn and Hugo van Ingen


Open access peer-reviewed

3. Chromatin Dynamics upon DNA Damage

By Judith Miné-Hattab and Xavier Darzacq


Open access peer-reviewed

4. A Consistent Systems Mechanics Model of the 3D Architecture and Dynamics of Genomes

By Tobias A. Knoch


Open access peer-reviewed

5. Apicomplexa and Histone Variants: What’s New?

By Laura Vanagas, Susana Marisol Contreras and Sergio Oscar Angel


Open access peer-reviewed

6. Epigenetic Modulation of Circadian Rhythms: Bmal1 Gene Regulation

By Tatsunosuke Tomita and Yoshiaki Onishi


Open access peer-reviewed

7. Epigenome Editing

By Paul Enríquez


Open access peer-reviewed

8. Resetting Cell Fate by Epigenetic Reprogramming

By Molly Pui Man Wong and Ray Kit Ng


Open access peer-reviewed

9. Cytosine Modifications and Distinct Functions of TET1 on Tumorigenesis

By Cuili Ma, Pengfei Ji, Nina Xie and Yujing Li


Open access peer-reviewed

10. Role of COX-2 Promoter Methylation and Helicobacter pylori Infection in Impaired Gastric Ulcer Healing

By Hiroshi Yasuda, Yoshiyuki Watanabe, Ritsuko Oikawa and Fumio Itoh


Open access peer-reviewed

11. Epigenetic Regulation of Hepatitis B Virus Replication

By In Young Moon and Jin-Wook Kim


Open access peer-reviewed

12. Part 1: The PIWI-piRNA Pathway Is an Immune-Like Surveillance Process That Controls Genome Integrity by Silencing Transposable Elements

By Didier Meseure and Kinan Drak Alsibai


Open access peer-reviewed

13. Part 2: Deregulated Expressions of PIWI Proteins and piRNAs as New Candidate Biomarkers and Potential Therapeutic Tools in Cancer

By Didier Meseure and Kinan Drak Alsibai


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£119

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase