Open access peer-reviewed Edited Volume

Biology of Trypanosoma cruzi

Edited by Wanderley De Souza

Federal University of Rio de Janeiro

Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease.

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Biology of Trypanosoma cruziEdited by Wanderley De Souza

Published: December 18th 2019

DOI: 10.5772/intechopen.80373

ISBN: 978-1-83968-204-9

Print ISBN: 978-1-83968-203-2

eBook (PDF) ISBN: 978-1-83968-205-6

Copyright year: 2019

Books open for chapter submissions

4606 Total Chapter Downloads

4 Crossref Citations

3 Web of Science Citations

8 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Biology of Trypanosoma cruzi

By Wanderley de Souza


Open access peer-reviewed

2. Life Cycle of Trypanosoma cruzi in the Invertebrate and the Vertebrate Hosts

By Kenechukwu C. Onyekwelu


Open access peer-reviewed

3. Cell Culture and Maintenance of the Evolutionary Forms of Trypanosoma cruzi for Studies of Parasitic Biology

By Cláudia Jassica Gonçalves Moreno, Johny Wysllas de Freitas Oliveira, Joice Castelo Branco, Laura Araújo, Aline Maria Queiroz, Sílvia Tavares Donato, Nilton José da Silva Júnior, Emilly Thays da Silva Rodrigues and Marcelo Sousa Silva


Open access peer-reviewed

4. Amazonian Reservoir Hosts of Trypanosoma cruzi

By Jocelyn Ginette Pérez Lazo, Pedro Mayor and Andrés G. Lescano


Open access peer-reviewed

5. Role of Proteomics in the Study of Trypanosoma cruzi Biology

By Juan San Francisco, Bessy Gutiérrez and Jorge González


Open access peer-reviewed

6. Biology of the Trypanosoma cruzi Genome

By Luisa Berná, Sebastián Pita, María Laura Chiribao, Adriana Parodi-Talice, Fernando Alvarez-Valin and Carlos Robello


Open access peer-reviewed

7.l-arginine Metabolism in the Infection with Trypanosoma cruzi

By Laila Gutiérrez-Kobeh and Arturo A. Wilkins-Rodríguez


Open access peer-reviewed

8. The Journey of Trypanosoma cruzi under the Redox Baton

By Marcia Cristina Paes


Open access peer-reviewed

9. How Does the Main Infective Stage of T. cruzi Enter and Avoid Degradation in Host Cells? A Description of the Pathways and Organelles Involved on These Processes

By Emile Barrias, Lissa C. Reignault and Wanderley de Souza


Open access peer-reviewed

10. Possible Role of Gap Junction Channels and Non-Junctional Channels in the Infection Caused by Trypanosoma cruzi

By José Luis Vega, Camilo Juyumaya, Luis Rodríguez, Juan Güiza, Camila Gutíerrez, Iván Barría and Juan C. Sáez


Open access peer-reviewed

11. Trypanosoma cruzi Infection: Mechanisms of Evasion of Immune Response

By Alondra Cruz Reyes and José Luis Rosales Encina


Open access peer-reviewed

12. Fish Oil and Inflammation: A Perspective on the Challenges of Evaluating Efficacy in Trypanosoma cruzi Infection

By Maria Isabel Lovo-Martins, Marli Cardoso Martins-Pinge and Phileno Pinge-Filho


Open access peer-reviewed

13. Parasite, Compartments, and Molecules: Trick versus Treatment on Chagas Disease

By Marcos André Vannier-Santos, Giselle V. Brunoro, Maria de Nazaré C. Soeiro, Solange L. DeCastro and Rubem F.S. Menna-Barreto


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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