Open access peer-reviewed Edited volume

Bacterial Artificial Chromosomes

Edited by Pradeep Chatterjee

North Carolina Central University, United States of America

This book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the large infectious DNA genomes of viruses. The large size of the insert DNA in BACs and the ease of engineering mutations in that DNA within the bacterial host, allowed manipulating the BAC-viral DNA of Varicella-Zoster Virus. Other reviews include the maintenance and suitable expression of foreign genes from a Baculovirus genome, including protein complexes, from the BAC-viral DNA and generating vaccines from BAC-viral DNA genomes of Marek's disease virus. Production of multi-purpose BAC clones in the novel Bacillus subtilis host is described, along with chapters that illustrate the use of BAC transgenic animals to address important issues of gene regulation in vertebrates, such as functionally identifying novel cis-acting distal gene regulatory sequences.

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Bacterial Artificial ChromosomesEdited by Pradeep Chatterjee

Published: November 25th 2011

DOI: 10.5772/1064

ISBN: 978-953-307-725-3

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Open access peer-reviewed

1. BAC Libraries: Precious Resources for Marsupial and Monotreme Comparative Genomics

By Janine E. Deakin

1326

Open access peer-reviewed

2. Recombineering of BAC DNA for the Generation of Transgenic Mice

By John J. Armstrong and Karen K. Hirschi

2917

Open access peer-reviewed

3. Defining the Deletion Size in Williams-Beuren Syndrome by Fluorescent In Situ Hybridization with Bacterial Artificial Chromosomes

By Audrey Basinko, Nathalie Douet-Guilbert, Séverine Audebert-Bellanger, Philippe Parent, Clémence Chabay-Vichot, Clément Bovo, Nadia Guéganic, Marie-Josée Le Bris, Frédéric Morel and Marc De Braekeleer

1754

Open access peer-reviewed

4. Functionalizing Bacterial Artificial Chromosomes with Transposons to Explore Gene Regulation

By Hope M. Wolf, Oladoyin Iranloye, Derek C. Norford and Pradeep K. Chatterjee

1256

Open access peer-reviewed

5. Functional Profiling of Varicella-Zoster Virus Genome by Use of a Luciferase Bacterial Artificial Chromosome System

By Lucy Zhu and Hua Zhu

1586

Open access peer-reviewed

6. Gene Functional Studies Using Bacterial Artificial Chromosome (BACs)

By Mingli Liu, Shanchun Guo, Monica Battle and Jonathan K. Stiles

5429

Open access peer-reviewed

7. Bacterial Artificial Chromosome-Based Experimental Strategies in the Field of Developmental Neuroscience

By Youhei W. Terakawa, Yukiko U. Inoue, Junko Asami and Takayoshi Inoue

1154

Open access peer-reviewed

8. Production of Multi-Purpose BAC Clones in the Novel Bacillus subtilis Based Host Systems

By Shinya Kaneko and Mitsuhiro Itaya

1410

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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16832total chapter downloads

5Web of Science citations

2Crossref citations

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