Open access peer-reviewed Edited Volume

Bacterial Artificial Chromosomes

Edited by Pradeep Chatterjee

North Carolina Central University, United States of America

This book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the large infectious DNA genomes of viruses. The large size of the insert DNA in BACs and the ease of engineering mutations in that DNA within the bacterial host, allowed manipulating the BAC-viral DNA of Varicella-Zoster Virus. Other reviews include the maintenance and suitable expression of foreign genes from a Baculovirus genome, including protein complexes, from the BAC-viral DNA and generating vaccines from BAC-viral DNA genomes of Marek's disease virus. Production of multi-purpose BAC clones in the novel Bacillus subtilis host is described, along with chapters that illustrate the use of BAC transgenic animals to address important issues of gene regulation in vertebrates, such as functionally identifying novel cis-acting distal gene regulatory sequences.

Read more >Order hardcopy
Bacterial Artificial ChromosomesEdited by Pradeep Chatterjee

Published: November 25th 2011

DOI: 10.5772/1064

ISBN: 978-953-307-725-3

eBook (PDF) ISBN: 978-953-51-5175-3

Copyright year: 2011

Books open for chapter submissions

20636 Total Chapter Downloads

2 Crossref Citations

8 Web of Science Citations

6 Dimensions Citations


Open access peer-reviewed

1. BAC Libraries: Precious Resources for Marsupial and Monotreme Comparative Genomics

By Janine E. Deakin


Open access peer-reviewed

2. Recombineering of BAC DNA for the Generation of Transgenic Mice

By John J. Armstrong and Karen K. Hirschi


Open access peer-reviewed

3. Defining the Deletion Size in Williams-Beuren Syndrome by Fluorescent In Situ Hybridization with Bacterial Artificial Chromosomes

By Audrey Basinko, Nathalie Douet-Guilbert, Séverine Audebert-Bellanger, Philippe Parent, Clémence Chabay-Vichot, Clément Bovo, Nadia Guéganic, Marie-Josée Le Bris, Frédéric Morel and Marc De Braekeleer


Open access peer-reviewed

4. Functionalizing Bacterial Artificial Chromosomes with Transposons to Explore Gene Regulation

By Hope M. Wolf, Oladoyin Iranloye, Derek C. Norford and Pradeep K. Chatterjee


Open access peer-reviewed

5. Functional Profiling of Varicella-Zoster Virus Genome by Use of a Luciferase Bacterial Artificial Chromosome System

By Lucy Zhu and Hua Zhu


Open access peer-reviewed

6. Gene Functional Studies Using Bacterial Artificial Chromosome (BACs)

By Mingli Liu, Shanchun Guo, Monica Battle and Jonathan K. Stiles


Open access peer-reviewed

7. Bacterial Artificial Chromosome-Based Experimental Strategies in the Field of Developmental Neuroscience

By Youhei W. Terakawa, Yukiko U. Inoue, Junko Asami and Takayoshi Inoue


Open access peer-reviewed

8. Production of Multi-Purpose BAC Clones in the Novel Bacillus subtilis Based Host Systems

By Shinya Kaneko and Mitsuhiro Itaya


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£119

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase