Open access peer-reviewed Edited Volume

Autoimmunity

Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases

Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.

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8680 Total Chapter Downloads

5 Crossref Citations

2 Web of Science Citations

11 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Crosstalk Between Oxidative Stress, Autophagy and Cell Death — Pathogenesis of Autoimmune Disease

By Dilip Shah, Dheeraj Mohania, Nidhi Mahajan, Sangita Sah, Bishnuhari Paudyal and Swapan K. Nath

1168

Open access peer-reviewed

2. Role of C1q in Efferocytosis and Self-Tolerance — Links With Autoimmunity

By Philippe Frachet, Pascale Tacnet-Delorme, Christine Gaboriaud and Nicole M. Thielens

1154

Open access peer-reviewed

3. Implication of Regional Activation of Toll-Like Receptor 3/ Interferon-β Signaling in Human Mesangial Cells — Possible Involvement in the Pathogenesis of Lupus Nephritis

By Hiroshi Tanaka, Kazushi Tsuruga and Tadaatsu Imaizumi

603

Open access peer-reviewed

4. Autoimmunity in Children with Primary Immunodeficiency – Diagnosis, Management and Therapy

By Anna Pituch-Noworolska

809

Open access peer-reviewed

5. A Concise Review of Autoimmune Liver Diseases

By Nwe Ni Than and Ye Htun Oo

1685

Open access peer-reviewed

6. Celiac Disease and Other Autoimmune Disorders

By M.I. Torres, T. Palomeque and P. Lorite

1036

Open access peer-reviewed

7. Vitiligo – A Complex Autoimmune Skin Depigmenting Disease

By Mitesh Dwivedi, Naresh C. Laddha, Anthony P. Weetman, Rasheedunnisa Begum and Helen Kemp

1352

Open access peer-reviewed

8. Will Understanding Methotrexate Modes of Action Teach us About Rheumatoid Arthritis?

By Charles F. Spurlock III, Nancy J. Olsen and Thomas M. Aune

873

Edited Volume and chapters are indexed in

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