Open access peer-reviewed Edited Volume

Atomic Force Microscopy Investigations into Biology

From Cell to Protein

Edited by Christopher Frewin

University of South Florida, United States of America

The atomic force microscope (AFM) has become one of the leading nanoscale measurement techniques for materials science since its creation in the 1980's, but has been gaining popularity in a seemingly unrelated field of science: biology. The AFM naturally lends itself to investigating the topological surfaces of biological objects, from whole cells to protein particulates, and can also be used to determine physical properties such as Young's modulus, stiffness, molecular bond strength, surface friction, and many more. One of the most important reasons for the rise of biological AFM is that you can measure materials within a physiologically relevant environment (i.e. liquids). This book is a collection of works beginning with an introduction to the AFM along with techniques and methods of sample preparation. Then the book displays current research covering subjects ranging from nano-particulates, proteins, DNA, viruses, cellular structures, and the characterization of living cells.

Read more >Order hardcopy
Atomic Force Microscopy Investigations into BiologyFrom Cell to ProteinEdited by Christopher Frewin

Published: March 7th 2012

DOI: 10.5772/2092

ISBN: 978-953-51-0114-7

eBook (PDF) ISBN: 978-953-51-5228-6

Copyright year: 2012

Books open for chapter submissions

53627 Total Chapter Downloads

10 Crossref Citations

35 Web of Science Citations

36 Dimensions Citations


Open access peer-reviewed

1. Atomic Force Spectroscopies: A Toolbox for Probing the Biological Matter

By Michele Giocondo, Said Houmadi, Emanuela Bruno, Maria P. De Santo, Luca De Stefano, Emmanuelle Lacaze, Sara Longobardi and Paola Giardina


Open access peer-reviewed

2. Artifacts in Atomic Force Microscopy of Biological Samples

By E. Ukraintsev, A. Kromka, H. Kozak, Z. Remeš and B. Rezek


Open access peer-reviewed

3. Tapping Mode AFM Imaging for Functionalized Surfaces

By Nadine Mourougou-Candoni


Open access peer-reviewed

4. AFM Measurements to Investigate Particulates and Their Interactions with Biological Macromolecules

By L. Latterini and L. Tarpani


Open access peer-reviewed

5. AFM Imaging of Biological Supramolecules by a Molecular Imprinting-Based Immobilization Process on a Photopolymer

By Taiji Ikawa


Open access peer-reviewed

6. Protein Interactions on Phospholipid Bilayer, Studied by AFM Under Physiological Conditions

By Špela Irman, Miha Škarabot, Igor Muševič and Borut Božič


Open access peer-reviewed

7. Nanomechanics of Amyloid Materials Studied by Atomic Force Microscopy

By Guanghong Zeng, Yusheng Duan, Flemming Besenbacher and Mingdong Dong


Open access peer-reviewed

8. Analyzing DNA Structure Quantitatively at a Single-Molecule Level by Atomic Force Microscopy

By Yong Jiang and Yuan Yin


Open access peer-reviewed

9. Atomic Force Microscopy of Chromatin

By Delphine Quénet, Emilios K. Dimitriadis and Yamini Dalal


Open access peer-reviewed

10. Artificial and Natural Membranes

By György Váró and Zsolt Szegletes


Open access peer-reviewed

11. Atomic Force Microscopy in Detection of Viruses

By Norma Hernández-Pedro, Edgar Rangel-López, Benjamín Pineda and Julio Sotelo


Open access peer-reviewed

12. Force Microscopy – A Tool to Elucidate the Relationship Between Nanomechanics and Function in Viruses

By J.L. Cuéllar and E. Donath


Open access peer-reviewed

13. Single-Molecule Force Microscopy: A Potential Tool for the Mapping of Polysaccharides in Plant Cell Walls

By Julian C. Thimm, Laurence D. Melton and David J. Burritt


Open access peer-reviewed

14. AFM and Cell Staining to Assess the In Vitro Biocompatibility of Opaque Surfaces

By Christopher L. Frewin, Alexandra Oliveros, Edwin Weeber and Stephen E. Saddow


Open access peer-reviewed

15. The Transversal Stiffness of Skeletal Muscle Fibers and Cardiomyocytes in Control and After Simulated Microgravity

By Irina V. Ogneva and Igor B. Ushakov


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£139

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase