Open access peer-reviewed Edited volume

Alzheimer's Disease

Challenges for the Future

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

Read more >Order hardcopy
IntechOpen
Alzheimer's DiseaseChallenges for the FutureEdited by Inga Zerr

Published: July 1st 2015

DOI: 10.5772/58663

ISBN: 978-953-51-2137-4

Copyright year: 2015

Books open for chapter submissions

10465 Total Chapter Downloads

4 Crossref Citations

3 Web of Science Citations

11 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Epidemiology of Alzheimer's Disease with the Projection of Falls Among the Aged Population

By Aysegul Uludag, Sibel Cevizci and Ahmet Uludag

769

Open access peer-reviewed

2. The Cascade of Oxidative Stress and Tau Protein Autophagic Dysfunction in Alzheimer’s Disease

By Zhenzhen Liu, Peifu Li, Jiannan Wu, Yi Wang, Ping Li, Xinxin Hou, Qingling Zhang, Nannan Wei, Zhiquan Zhao, Huimin Liang and Jianshe Wei

1034

Open access peer-reviewed

3. Neuroinflammation and Alteration of the Blood-Brain Barrier in Alzheimer´s Disease

By Luis Oskar Soto-Rojas, Fidel de la Cruz-López, Miguel Angel Ontiveros Torres, Amparo Viramontes-Pintos, María del Carmen Cárdenas-Aguayo, Marco A. Meraz-Ríos, Citlaltepetl Salinas-Lara, Benjamín Florán-Garduño and José Luna-Muñoz

1028

Open access peer-reviewed

4. Metals Involvement in Alzheimer’s Disease — A Patho-Genetic View

By Carlo Salustri, Mariacristina Siotto, Serena Bucossi and Rosanna Squitti

788

Open access peer-reviewed

5. Lipids and Lipoproteins in Alzheimer’s Disease

By Sophie Stukas, Iva Kulic, Shahab Zareyan and Cheryl L. Wellington

564

Open access peer-reviewed

6. Free Cholesterol — A Double-Edge Sword in Alzheimer Disease

By José C. Fernández-Checa

740

Open access peer-reviewed

7. The Mevalonate Pathway in Alzheimer’s Disease — Cholesterol and Non-Sterol Isoprenoids

By Amany Mohamed, Kevan Smith and Elena Posse de Chaves

1254

Open access peer-reviewed

8. Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer’s Disease in Clinical Practice and to Assist Human Clinical Trials

By Francois Bernier, Pavan Kumar, Yoshiaki Sato and Yoshiya Oda

802

Open access peer-reviewed

9. New Frontiers in Alzheimer's Disease Diagnosis

By Franc Llorens, Sabine Nuhn, Christoph Peter, Inga Zerr and Katharina Stoeck

711

Open access peer-reviewed

10. Genetic, Biochemical and Histopathological Aspects of Familiar Alzheimer's Disease

By Genaro Gabriel Ortiz, Fermín P. Pacheco-Moisés, Erika D. González- Renovato, Luis Figuera, Miguel A. Macías-Islas, Mario Mireles- Ramírez, L. Javier Flores-Alvarado, Angélica Sánchez-López, Dhea G. Nuño-Penilla, Irma E. Velázquez- Brizuela, Juan P. Sánchez-Luna and Alfredo Célis de la Rosa

939

Open access peer-reviewed

11. Gait Pathway in Subcortical Vascular Dementia and in Alzheimer’s Disease

By Rita Moretti, Arianna Sartori, Beatrice Baso and Silvia Gazzin

630

Open access peer-reviewed

12. The Alzheimer’s Patient in the Emergency Department — Specificities of Care

By De Breucker Sandra, Pepersack Thierry and Bier Jean-Christophe

559

Open access peer-reviewed

13. Uncontrolled Sexual Behaviour in Dementia

By Susan van Hooren and Wim Waterink

647

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited volume

Free shipping with DHL Express

Hardcover (ex. VAT)£170

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase