Open access peer-reviewed Edited volume

Alzheimer's Disease

Challenges for the Future

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

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Alzheimer's DiseaseChallenges for the FutureEdited by Inga Zerr

Published: July 1st 2015

DOI: 10.5772/58663

ISBN: 978-953-51-2137-4

Books open for chapter submissions

9770 Total Chapter Downloads

4 Crossref Citations

3 Web of Science Citations

7 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Epidemiology of Alzheimer's Disease with the Projection of Falls Among the Aged Population

By Aysegul Uludag, Sibel Cevizci and Ahmet Uludag

719

Open access peer-reviewed

2. The Cascade of Oxidative Stress and Tau Protein Autophagic Dysfunction in Alzheimer’s Disease

By Zhenzhen Liu, Peifu Li, Jiannan Wu, Yi Wang, Ping Li, Xinxin Hou, Qingling Zhang, Nannan Wei, Zhiquan Zhao, Huimin Liang and Jianshe Wei

977

Open access peer-reviewed

3. Neuroinflammation and Alteration of the Blood-Brain Barrier in Alzheimer´s Disease

By Luis Oskar Soto-Rojas, Fidel de la Cruz-López, Miguel Angel Ontiveros Torres, Amparo Viramontes-Pintos, María del Carmen Cárdenas-Aguayo, Marco A. Meraz-Ríos, Citlaltepetl Salinas-Lara, Benjamín Florán-Garduño and José Luna-Muñoz

962

Open access peer-reviewed

4. Metals Involvement in Alzheimer’s Disease — A Patho-Genetic View

By Carlo Salustri, Mariacristina Siotto, Serena Bucossi and Rosanna Squitti

734

Open access peer-reviewed

5. Lipids and Lipoproteins in Alzheimer’s Disease

By Sophie Stukas, Iva Kulic, Shahab Zareyan and Cheryl L. Wellington

524

Open access peer-reviewed

6. Free Cholesterol — A Double-Edge Sword in Alzheimer Disease

By José C. Fernández-Checa

696

Open access peer-reviewed

7. The Mevalonate Pathway in Alzheimer’s Disease — Cholesterol and Non-Sterol Isoprenoids

By Amany Mohamed, Kevan Smith and Elena Posse de Chaves

1150

Open access peer-reviewed

8. Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer’s Disease in Clinical Practice and to Assist Human Clinical Trials

By Francois Bernier, Pavan Kumar, Yoshiaki Sato and Yoshiya Oda

754

Open access peer-reviewed

9. New Frontiers in Alzheimer's Disease Diagnosis

By Franc Llorens, Sabine Nuhn, Christoph Peter, Inga Zerr and Katharina Stoeck

654

Open access peer-reviewed

10. Genetic, Biochemical and Histopathological Aspects of Familiar Alzheimer's Disease

By Genaro Gabriel Ortiz, Fermín P. Pacheco-Moisés, Erika D. González- Renovato, Luis Figuera, Miguel A. Macías-Islas, Mario Mireles- Ramírez, L. Javier Flores-Alvarado, Angélica Sánchez-López, Dhea G. Nuño-Penilla, Irma E. Velázquez- Brizuela, Juan P. Sánchez-Luna and Alfredo Célis de la Rosa

860

Open access peer-reviewed

11. Gait Pathway in Subcortical Vascular Dementia and in Alzheimer’s Disease

By Rita Moretti, Arianna Sartori, Beatrice Baso and Silvia Gazzin

595

Open access peer-reviewed

12. The Alzheimer’s Patient in the Emergency Department — Specificities of Care

By De Breucker Sandra, Pepersack Thierry and Bier Jean-Christophe

531

Open access peer-reviewed

13. Uncontrolled Sexual Behaviour in Dementia

By Susan van Hooren and Wim Waterink

614

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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