Open access peer-reviewed Edited Volume

Advances in Protein Kinases

Edited by Gabriela Da Silva Xavier

Imperial College London, United Kingdom

Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.

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Advances in Protein KinasesEdited by Gabriela Da Silva Xavier

Published: June 5th 2012

DOI: 10.5772/2692

ISBN: 978-953-51-0633-3

Copyright year: 2012

Books open for chapter submissions

18416 Total Chapter Downloads

4 Crossref Citations

7 Web of Science Citations

15 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Cross-Regulation of JAK-STAT Signaling: Implications for Approaches to Combat Chronic Inflammatory Diseases and Cancers

By Claire Rutherford, Hayley D. Woolson and Timothy M. Palmer

1301

Open access peer-reviewed

2. Interactions of the Protein Kinase A Signaling Pathway: Implications for the Treatment of Endocrine and Other Tumors

By Audrey J. Robinson-White

1801

Open access peer-reviewed

3. The Role of Tpl2 Protein Kinase in Carcinogenesis and Inflammation

By Katie DeCicco-Skinner, Monika Deshpande and Jonathan Wiest

2101

Open access peer-reviewed

4. MEK1/2 Inhibitors to Treat Dilated Cardiomyopathy Caused by LMNA Mutations

By Antoine Muchir

844

Open access peer-reviewed

5. Signaling Pathways Coupled to Activation of the Kinin B1 Receptor

By Pamela Ehrenfeld, Carlos D. Figueroa, Kanti D. Bhoola and Carola E. Matus

2458

Open access peer-reviewed

6. Multiple Kinase Involvement in the Regulation of Vascular Growth

By Shaquria P. Adderley, Chintamani N. Joshi, Danielle N. Martin, Shayna Mooney and David A. Tulis

969

Open access peer-reviewed

7. The Physiological Relationship of Endothelial Protein Kinase G with Endothelial Nitric Oxide Synthase

By Theresa A. John and J. Usha Raj

1034

Open access peer-reviewed

8. The Role of Tyrosine Kinases in the Pathogenesis and Treatment of Lung Disease

By Jonathan Lam and Stewart J. Levine

1579

Open access peer-reviewed

9. Myotonic Dystrophy Protein Kinase: Structure, Function and Its Possible Role in the Pathogenesis of Myotonic Dystrophy Type 1

By Jonathan J. Magaña, Rocío Suárez-Sánchez, Norberto Leyva-García, Bulmaro Cisneros and Oscar Hernández-Hernández

1880

Open access peer-reviewed

10. Protein Kinases in the Pathogenesis of Muscle Wasting

By Fabio Penna, Domiziana Costamagna, Andrea Camperi, Maurizio Muscaritoli, Francesco M. Baccino and Paola Costelli

992

Open access peer-reviewed

11. Mathematical Modeling of Syk Activation in Allergen-Stimulated Mast Cells and Basophils

By Ambarish Nag, Michael I. Monine, Byron Goldstein, James R. Faeder and Michael L. Blinov

1049

Open access peer-reviewed

12. Roles of Kinases in Osteoblast Function

By Tetsuya Matsuguchi

1455

Open access peer-reviewed

13. The Role of Mitogen-Activated Protein Kinase in Treatment Strategies for Fear and Drug Addiction

By Robyn Mary Brown, Andrew J. Lawrence and Jee Hyun Kim

953

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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