Open access peer-reviewed Edited Volume

Advances in Protein Kinases

Edited by Gabriela Da Silva Xavier

Imperial College London, United Kingdom

Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.

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Advances in Protein KinasesEdited by Gabriela Da Silva Xavier

Published: June 5th 2012

DOI: 10.5772/2692

ISBN: 978-953-51-0633-3

eBook (PDF) ISBN: 978-953-51-5301-6

Copyright year: 2012

Books open for chapter submissions

21975 Total Chapter Downloads

5 Crossref Citations

9 Web of Science Citations

17 Dimensions Citations


Open access peer-reviewed

1. Cross-Regulation of JAK-STAT Signaling: Implications for Approaches to Combat Chronic Inflammatory Diseases and Cancers

By Claire Rutherford, Hayley D. Woolson and Timothy M. Palmer


Open access peer-reviewed

2. Interactions of the Protein Kinase A Signaling Pathway: Implications for the Treatment of Endocrine and Other Tumors

By Audrey J. Robinson-White


Open access peer-reviewed

3. The Role of Tpl2 Protein Kinase in Carcinogenesis and Inflammation

By Katie DeCicco-Skinner, Monika Deshpande and Jonathan Wiest


Open access peer-reviewed

4. MEK1/2 Inhibitors to Treat Dilated Cardiomyopathy Caused by LMNA Mutations

By Antoine Muchir


Open access peer-reviewed

5. Signaling Pathways Coupled to Activation of the Kinin B1 Receptor

By Pamela Ehrenfeld, Carlos D. Figueroa, Kanti D. Bhoola and Carola E. Matus


Open access peer-reviewed

6. Multiple Kinase Involvement in the Regulation of Vascular Growth

By Shaquria P. Adderley, Chintamani N. Joshi, Danielle N. Martin, Shayna Mooney and David A. Tulis


Open access peer-reviewed

7. The Physiological Relationship of Endothelial Protein Kinase G with Endothelial Nitric Oxide Synthase

By Theresa A. John and J. Usha Raj


Open access peer-reviewed

8. The Role of Tyrosine Kinases in the Pathogenesis and Treatment of Lung Disease

By Jonathan Lam and Stewart J. Levine


Open access peer-reviewed

9. Myotonic Dystrophy Protein Kinase: Structure, Function and Its Possible Role in the Pathogenesis of Myotonic Dystrophy Type 1

By Jonathan J. Magaña, Rocío Suárez-Sánchez, Norberto Leyva-García, Bulmaro Cisneros and Oscar Hernández-Hernández


Open access peer-reviewed

10. Protein Kinases in the Pathogenesis of Muscle Wasting

By Fabio Penna, Domiziana Costamagna, Andrea Camperi, Maurizio Muscaritoli, Francesco M. Baccino and Paola Costelli


Open access peer-reviewed

11. Mathematical Modeling of Syk Activation in Allergen-Stimulated Mast Cells and Basophils

By Ambarish Nag, Michael I. Monine, Byron Goldstein, James R. Faeder and Michael L. Blinov


Open access peer-reviewed

12. Roles of Kinases in Osteoblast Function

By Tetsuya Matsuguchi


Open access peer-reviewed

13. The Role of Mitogen-Activated Protein Kinase in Treatment Strategies for Fear and Drug Addiction

By Robyn Mary Brown, Andrew J. Lawrence and Jee Hyun Kim


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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