Open access peer-reviewed Edited Volume

Adult Stem Cell Niches

Edited by Sabine Wislet

University of Liège, Belgium

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

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Adult Stem Cell NichesEdited by Sabine Wislet

Published: August 1st 2014

DOI: 10.5772/57290

ISBN: 978-953-51-1718-6

eBook (PDF) ISBN: 978-953-51-7220-8

Copyright year: 2014

Books open for chapter submissions

13727 Total Chapter Downloads

8 Crossref Citations

8 Web of Science Citations

19 Dimensions Citations


Open access peer-reviewed

1. Delineation of Niches which Support Hematopoiesis

By Hong Kiat Lim and Helen C. O’Neill


Open access peer-reviewed

2. The Adult Hematopoietic Niches — Cellular Composition, Histological Organization and Physiological Regulation

By Agustín G Zapata


Open access peer-reviewed

3. CXCR4 in Central and Peripheral Lymphoid Niches – Physiology, Pathology and Therapeutic Perspectives in Immune Deficiencies and Malignancies

By Christelle Freitas, Alexandre Bignon, Karl Balabanian and Ali Dalloul


Open access peer-reviewed

4. Hematopoietic Stem Cells, Tumor Cells and Lymphocytes — Party in the Bone Marrow

By Adriana Bonomo, Ana Carolina Monteiro and Alex Balduíno


Open access peer-reviewed

5. Male stem Cell Niche and Spermatogenesis in the Drosophila testis — A Tale of Germline-Soma Communication

By Fani Papagiannouli


Open access peer-reviewed

6. Adult Stem Cell Niches — Stem Cells in the Female Reproductive System

By Mirjana Kessler, Rike Zietlow and Thomas F. Meyer


Open access peer-reviewed

7. Adult Hepatic Progenitor Cells

By Peter Siig Vestentoft


Open access peer-reviewed

8. Typical and Atypical Stem Cell Niches of the Adult Nervous System in Health and Inflammatory Brain and Spinal Cord Diseases

By Joshua Bernstock, Jeroen Verheyen, Bing Huang, John Hallenbeck and Stefano Pluchino


Open access peer-reviewed

9. The Role of the “Cancer Stem Cell Niche” in Cancer Initiation and Progression

By Jacqueline E. Noll, Kate Vandyke and Andrew C.W. Zannettino


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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