1.1. The definition of ‘acne’ and ‘acneiform’
Acne vulgaris (AV) is a multifactorial disease of pilosebaceous unit and is a prototype of acneiform dermatoses. The term ‘acneiform’ refers to dermatoses which resemble acne vulgaris clinically but have different etiopathogenesis . Acneiform dermatoses include a wide range of diseases which can occur in all age groups from infancy to elderly. They are so prevalent in all around the world that only AV rate has been reported to be 40–50 million/year in the USA and its prevalence has been estimated as 100% among adolescents in United Kingdom [2, 3]. Acneiform dermatoses have also important economic burden on governments due to high prevalence [2, 4].
AV lesions develop due to increased sebum production, follicular epidermal hyperproliferation, inflammation and
Although acne is mostly seen in adolescence period, it may be seen in pediatric age group. Neonatal acne is a temporary and benign acne variant characterized by millimetric inflammatory papules on cheeks and across the nasal bridge which appears usually during the neonatal period . Increased sebum secretion due to stimulation of neonatal sebaceous glands with maternal hormones, and
Severity of AV may change from mild to severe. Moreover, in acne fulminans (acute febrile ulcerative acne), which is the most severe acne form, systemic symptoms such as fever, arthralgia, myalgia, fatigue, hepatosplenomegaly and osteolytic bone lesions may accompany to skin lesions that are characterized by suddenly appeared multiple, tender, inflammatory nodular, suppurative lesions and ulcers with hemorrhagic crusts on the back and chest. Increased sedimentation rate, proteinuria, leukocytosis and anemia may also be seen. Acne conglobata is another severe nodulocystic acne form; however, in contrast to acne fulminans, it is not accompanied by any systemic symptoms. It is characterized by comedones, papules, pustules, nodules, abscesses and scars on the chest, back, buttocks, face, shoulders and thighs. Solid facial edema (Morbihan disease) is an important complication of acne characterized by woody enduration and erythema on midface and cheeks [7, 10].
Acne lesions sometimes may occur due to chronic friction, and this form is named as acne mechanica. It is characterized by comedones, which occur secondary to mechanic obstruction of pilosebaceous unit [7, 12]. Cosmetic acne is most commonly seen among young females and is associated with the application of cosmetics containing comedogenic substances. It is characterized by multiple comedones at the sites of cosmetic used [11, 12]. Excessive heat exposure may cause inflammatory nodulocystic acneiform lesions on body and arms and this entity is named as tropical acne [4, 7]. Acne aestivalis (Mallorca acne) is characterized by multiple papular lesions on cheeks, sides of the neck, chest, shoulders and upper arms that develop after sun exposure. UV radiation, especially UVA, is the responsible factor in the development of these lesions. Recurrences are common in successive years . Radiation acne refers to eruption, consisting of multiple comedone-like papules on the sites that are previously exposed to ionized radiation for treatment. Acne
Another form of acne, occupational acne, occurs as a result of occupational exposure to follicular occlusive compounds such as chlorinated hydrocarbons, coal tar derivatives. It is characterized by especially comedones on exposure sites, but inflammatory papules, pustules and cysts may be seen. Chloracne is the main example of occupational acne. It is characterized by multiple cysts, papules and nodules on malar, retroauricular, mandibular, aksillar regions and scrotum [7, 12].
With an increasing frequency in recent years, drug-induced acne characterized by a monomorphic eruption composed of inflammatory papule and pustules which occurs after usage of certain drugs. The distribution of lesions may be similar to AV; on the contrary, the onset is mostly acute, lesions are predominantly inflammatory and monomorphic and comedones are usually absent . Involvement of unusual localizations for AV (e.g. distal extremities), occurrence at an unusual age for AV, the history of exposure to one of the known causative drugs and regression of lesions after the cessation the offending agent are other clues for diagnoses [1, 13]. Steroid acne is the best known example of drug-induced acne. It may occur on chest and back as a result of systemic steroid usage or on face due to inappropriate or prolonged usage of topical steroids . Anabolic steroids, fenitoin, lithium, vitamins, cyclosporine, isoniazid, azathioprine, iodides, bromides and epidermal growth factor receptor inhibitors are the other major drugs which are responsible from acneiform eruptions [1, 13]. Lesions regress after the cessation of responsible agent .
Acne lesions are mostly seen in isolated manner however may develop as a component of some syndromes. SAPHO syndrome is characterized by any combination of
3. Acneifom dermatoses
The characteristic papulopustular lesions of Behcet disease are indistinguishable from AV clinically, but arms and legs involved preferentially in contrast to AV . Histologically vasculitis might be seen . It was reported that these lesions are usually observed in combination with arthritis .
Rosacea is a multifactorial disorder presented with acneiform lesions. It generally affects individuals with fair skin and older age compared to AV. There is a female predilection, but phymatous type occurs mostly in men. Vascular hyperreactivity and
Perioral and periorbital dermatitis is characterized by discrete, erythematous papules, plaques and pustules on erythematous base around mouth and eye, which characteristically spare the vermillion border. Although the relationship with rosacea is not clear, it has similar histopathological findings. Also, it responses to similar treatments. Pyoderma faciale is another entity that resembles rosacea histopathologically and responds similar treatment modalities. This disease is characterized by inflammatory papules, pustules and plaques on the midface. Systemic symptoms, such as fever, myalgia and laboratory findings (increased sedimentation rate and white blood cell count) may accompany with cutaneous symptoms in these patients. Inappropriate or long-term steroid usage may also cause rosacea formation or exacerbation (Steroid rosacea) [17, 18].
Usage of sun protection and avoidance from the factors that cause vasodilatation and irritation should be recommended to rosacea patients. Topical (metronidazole, sodium sulfacetamide, azelaic acid, tretioin) and systemic (antibiotics and retinoic acid) agents can be used in the treatment. Vascular lasers and intense pulsed light therapy can be used in the treatment of telangiectasias. Electrosurgery and carbon dioxide laser are the treatment options for the rhinophyma .
Demodicosis is a disease of the pilosebaceous unit associated with human
Acne and acneiform eruptions are frequent disorders in dermatology practice and the severity of diseases may change from self-limiting, benign condition to fulminant systemic disease. Etiopathogenesis of them are different. They may be seen as isolated or as a component of any syndrome. So, differential diagnoses of these diseases are important. Patient’s age, occupation, cosmetic usage, drug history, concomitant diseases, menstrual cycle irregularities and morphology and localization of lesions are important clues for diagnoses. To make an accurate diagnoses, detailed history, physical examination and, if necessary, histopathological examinations are essential. In this book, acne vulgaris and acneiform eruptions will be discussed in detail.