Open access peer-reviewed Edited Volume

Acute Leukemias

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Academic Editor

Pier Paolo Piccaluga
Pier Paolo Piccaluga

University of Bologna,
Italy

Published24 March 2021

Doi10.5772/intechopen.87292

ISBN978-1-83881-169-3

Print ISBN978-1-83881-168-6

eBook (PDF) ISBN978-1-83881-173-0

Copyright year2021

Number of pages322

Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia.

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Table of Contents

Open access  chapters

3. Reactive Oxygen Species and Metabolic Re-Wiring in Acute Leukemias

By Andrew J. Robinson, Richard L. Darley and Alex Tonks

757
4. The Key Role of the Phosphatase PP2A in the Development of Acute Myeloid Leukemia

By Javier Marco, Irene Peris, Carmen Vicente and Elena Arriazu

586
6. Self-Renewal Pathways in Acute Myeloid Leukemia Stem Cells

By Jonason Yang, Nunki Hassan, Sheng Xiang Franklin Chen, Jayvee Datuin and Jenny Y. Wang

998
7. MicroRNAs and Their Role in Acute Lymphoblastic Leukemia

By Edgardo Becerra Becerra and Guadalupe García-Alcocer

498
8. Acute Lymphoblastic Leukemia in Adolescents and Young Adults

By Martha Alvarado-Ibarra, José Antonio De la Peña Celaya, Luara Luz Arana-Luna, Eleazar Hernández-Ruiz, José Luis Alvarez Vera, María Eugenia Espitia Ríos and Juan Manuel Pérez Zúñiga

584
10. Treatment of AML in Older Patients

By Jacobien Hilberink and Gerwin Huls

661
1
11. Stem Cell Transplantation in Acute Myeloid Laeukemia

By Salvatore Leotta, Annalisa Condorelli, Giovanni Schininà, Roberta Sciortino, Alessandra Cupri and Giuseppe Milone

462
12. Consolidation: Autologous Stem Cell Transplantation in Acute Leukemia

By Fatma Keklik Karadağ, Fahri Şahin and Güray Saydam

572
646
15. Targeting of Post-Transcriptional Regulation as Treatment Strategy in Acute Leukemia

By Paulina Podszywalow-Bartnicka, Magdalena Wolczyk and Katarzyna Piwocka

457
16. Mechanisms of Resistence of New Target Drugs in Acute Myeloid Leukemia

By Debora Capelli, Francesco Saraceni, Diego Menotti, Alessandro Fiorentini and Attilio Olivieri

900

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