Open access peer-reviewed Edited Volume

Glutathione System and Oxidative Stress in Health and Disease

Edited by Margarete Dulce Bagatini

Universidade Federal da Fronteira Sul

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

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Glutathione System and Oxidative Stress in Health and DiseaseEdited by Margarete Dulce Bagatini

Published: August 26th 2020

DOI: 10.5772/intechopen.82965

ISBN: 978-1-83880-126-7

Print ISBN: 978-1-83880-125-0

eBook (PDF) ISBN: 978-1-83968-018-2

Copyright year: 2020

Books open for chapter submissions

2976 Total Chapter Downloads

6 Crossref Citations

13 Dimensions Citations


Open access peer-reviewed

1. Crosstalk between the Purinergic and Immune Systems: Implications for the Glutathione Antioxidant System in Health and Disease

By Charles Elias Assmann, Naiara Stefanello, Nathieli Bianchin Bottari, Jucimara Baldissarelli, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch and Margarete Dulce Bagatini


Open access peer-reviewed

2. Subcellular Localization of Glutathione Peroxidase, Change in Glutathione System during Ageing and Effects on Cardiometabolic Risks and Associated Diseases

By Théophile Mbemba Fundu, Paulin Mutwale Kapepula, Justin Mboloko Esimo, José Remacle and Nadege Kabamba Ngombe


Open access peer-reviewed

3. Glutathione Peroxidase in Health and Diseases

By Eren Sarıkaya and Selami Doğan


Open access peer-reviewed

4. Neurodegenerative Diseases: Potential Effect of Glutathione

By Aoula Moustapha


Open access peer-reviewed

5. Periodontal Health and Disease in Glutathione Peroxidase

By Figen Öngöz Dede


Open access peer-reviewed

6. Effect of Oxidative Stress on Sperm Cells

By Alejando Córdova Izquierdo, Adrian Emmanuel Iglesias Reyes, Alda Roció Ortiz Muñiz, María de Lourdes Juárez Mosqueda, Jesús Alberto Guevara González, Juan Eulogio Guerra Liera, Gustavo Ruiz Lang, Rubén Huerta Crispín, Abel E. Villa Mancera, Pedro Sánchez Aparico and Raúl Sánchez Sánchez


Open access peer-reviewed

7. Typical Catalases: Function and Structure

By Yonca Yuzugullu Karakus


Edited Volume and chapters are indexed in

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  • Base
  • CNKI

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