Open access peer-reviewed Edited Volume


Smart Materials for Biomedical Applications

Edited by Lacramioara Popa

Carol Davila University of Medicine and Pharmacy


Mihaela Violeta Ghica

Carol Davila University of Medicine and Pharmacy

Cristina Dinu-Pirvu

Carol Davila University of Medicine and Pharmacy

Hydrogels, as three-dimensional polymer networks, are able to retain a large amount of water in their swollen state. The biomedical application of hydrogels was initially hampered by the toxicity of cross-linking agents and the limitations of hydrogel formation under physiological conditions. However, emerging knowledge in polymer chemistry and an increased understanding of biological processes have resulted in the design of versatile materials and minimally invasive therapies.The novel but challenging properties of hydrogels are attracting the attention of researchers in the biological, medical, and pharmaceutical fields. In the last few years, new methods have been developed for the preparation of hydrophilic polymers and hydrogels, which may be used in future biomedical and drug delivery applications. Such efforts include the synthesis of self-organized nanostructures based on triblock copolymers with applications in controlled drug delivery. These hydrogels could be used as carriers for drug delivery when combined with the techniques of drug imprinting and subsequent release. Engineered protein hydrogels have many potential advantages. They are excellent biomaterials and biodegradables. Furthermore, they could encapsulate drugs and be used in injectable forms to replace surgery, to repair damaged cartilage, in regenerative medicine, or in tissue engineering. Also, they have potential applications in gene therapy, although this field is relatively new.

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HydrogelsSmart Materials for Biomedical ApplicationsEdited by Lacramioara Popa

Published: April 10th 2019

DOI: 10.5772/intechopen.78482

ISBN: 978-1-78985-876-1

Print ISBN: 978-1-78985-875-4

eBook (PDF) ISBN: 978-1-83962-121-5

Copyright year: 2019

Books open for chapter submissions

10450 Total Chapter Downloads

11 Crossref Citations

7 Web of Science Citations

35 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Hydrogels - From First Natural Hydrocolloids to Smart Biomaterials

By Lăcrămioara Popa, Mihaela Violeta Ghica and Cristina Elena Dinu-Pîrvu


Open access peer-reviewed

2. Stimuli-Responsive Hydrogels: An Interdisciplinary Overview

By Sudipta Chatterjee and Patrick Chi-leung Hui


Open access peer-reviewed

3. Investigating the Structure-Related Properties of Cellulose-Based Superabsorbent Hydrogels

By Christian Demitri, Marta Madaghiele, Maria Grazia Raucci, Alessandro Sannino and Luigi Ambrosio


Open access peer-reviewed

4. Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications

By Kessily B. Rufato, Juliana P. Galdino, Kamila S. Ody, Antonio G.B. Pereira, Elisangela Corradini, Alessandro F. Martins, Alexandre T. Paulino, André R. Fajardo, Fauze A. Aouada, Felipe A. La Porta, Adley F. Rubira and Edvani C. Muniz


Open access peer-reviewed

5. HyStem®: A Unique Clinical Grade Hydrogel for Present and Future Medical Applications

By Thomas I. Zarembinski and Aleksander Skardal


Edited Volume and chapters are indexed in

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