Open access peer-reviewed Edited Volume

Tumor Suppressor Genes

Edited by Yue Cheng

University of Hong Kong, China

Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.

Read more >Order hardcopy
Tumor Suppressor GenesEdited by Yue Cheng

Published: February 3rd 2012

DOI: 10.5772/1337

ISBN: 978-953-307-879-3

eBook (PDF) ISBN: 978-953-51-6744-0

Copyright year: 2012

Books open for chapter submissions

31466 Total Chapter Downloads

11 Crossref Citations

27 Web of Science Citations

30 Dimensions Citations


Open access peer-reviewed

1. Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate

By Payal Agarwal, Farruk Mohammad Lutful Kabir, Patricia DeInnocentes and Richard Curtis Bird


Open access peer-reviewed

2. Susceptibility of Epithelium to PTEN-Deficient Tumorigenesis

By Chun-Ming Chen, Tsai-Ling Lu, Fang-Yi Su and Li-Ru You


Open access peer-reviewed

3. Identification of Tumor Suppressor Genes via Cell Fusion and Chromosomal Transfer

By Hong Lok Lung, Arthur Kwok Leung Cheung, Josephine Mun Yee Ko, Yue Cheng and Maria Li Lung


Open access peer-reviewed

4. TP53 Gene Polymorphisms in Cancer Risk: The Modulating Effect of Ageing, Ethnicity and TP53 Somatic Abnormalities

By Evgeny V. Denisov, Nadezhda V. Cherdyntseva, Nicolay V. Litviakov, Elena A. Malinovskaya, Natalya N. Babyshkina, Valentina A. Belyavskaya and Mikhail I. Voevoda


Open access peer-reviewed

5. Epigenetics and Tumor Suppressor Genes

By MingZhou Guo, XueFeng Liu and WeiMin Zhang


Open access peer-reviewed

6. Therapeutic Targeting of p53-Mediated Apoptosis Pathway in Head and Neck Squamous Cell Carcinomas: Current Progress and Challenges

By Solachuddin Jauhari Arief Ichwan, Muhammad Taher Bakhtiar, Kiyoshi Ohtani and Masa-Aki Ikeda


Open access peer-reviewed

7. Signaling Mechanisms of Transforming Growth Factor-β (TGF-β) in Cancer: TGF-β Induces Apoptosis in Lung Cells by a Smad-Dependent Mechanism

By Mi Jung Lim, Tiffany Lin and Sonia B. Jakowlew


Open access peer-reviewed

8. Refining the role of Lgl, Dlg and Scrib in Tumor Suppression and Beyond: Learning from the Old Time Classics

By Fani Papagiannouli and Bernard M. Mechler


Open access peer-reviewed

9. Epigenetic and Posttranscriptional Alterations of Tumor Suppressor Genes in Sporadic Pituitary Adenomas

By Henriett Butz, Károly Rácz and Attila Patócs


Open access peer-reviewed

10. Genomic and Expression Alterations of Tumor Suppressor Genes in Meningioma Development, Progression and Recurrence

By E. Pérez-Magán, J.A. Rey, B. Meléndez and Javier S. Castresana


Open access peer-reviewed

11. Control of Retinal Development by Tumor Suppressor Genes

By Robert Cantrup, Gaurav Kaushik and Carol Schuurmans


Open access peer-reviewed

12. Properties of Human Tumor Suppressor 101F6 Protein as a Cytochrome b561 and Its Preliminary Crystallization Trials

By Mariam C. Recuenco, Suguru Watanabe, Fusako Takeuchi, Sam-Yong Park and Motonari Tsubaki


Open access peer-reviewed

13. Epigenetic Control of Tumor Suppressor Genes in Lung Cancer

By Xuan Qiu, Roman Perez-Soler and Yiyu Zou


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£139

Order now

Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase