Open access peer-reviewed Edited Volume


Some Physiological and Pathophysiological Aspects

Edited by Ivo Nikolaev Sirakov

Medical University of Sofia, Bulgaria

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

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PrionsSome Physiological and Pathophysiological AspectsEdited by Ivo Nikolaev Sirakov

Published: January 30th 2019

DOI: 10.5772/intechopen.74080

ISBN: 978-1-78985-018-5

Print ISBN: 978-1-78985-017-8

eBook (PDF) ISBN: 978-1-83881-768-8

Copyright year: 2019

Books open for chapter submissions

2086 Total Chapter Downloads

1 Crossref Citations

4 Web of Science Citations

3 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Prions

By Ivo Nikolaev Sirakov


Open access peer-reviewed

2. Prion Proteins and Neuronal Death in the Cerebellum

By Audrey Ragagnin, Qili Wang, Aurélie Guillemain, Siaka Dole, Anne-Sophie Wilding, Valérie Demais, Cathy Royer, Anne-Marie Haeberlé, Nicolas Vitale, Stéphane Gasman, Nancy Grant and Yannick Bailly


Open access peer-reviewed

3. A Molecular Mechanism for Abnormal Prion Protein Accumulation

By Keiji Uchiyama and Suehiro Sakaguchi


Open access peer-reviewed

4. Prion Protein Strain Diversity and Disease Pathology

By Saima Zafar, Neelam Younas, Mohsin Shafiq and Inga Zerr


Edited Volume and chapters are indexed in

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  • Base
  • CNKI

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