Open access peer-reviewed Edited Volume

Immune Response Activation and Immunomodulation

Edited by Rajeev Tyagi

Vanderbilt University Medical Centre (VUMC), Vanderbilt University


Prakash Singh Bisen

Jiwaji University

Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.

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Immune Response Activation and ImmunomodulationEdited by Rajeev Tyagi

Published: April 17th 2019

DOI: 10.5772/intechopen.73708

ISBN: 978-1-78985-152-6

Print ISBN: 978-1-78985-151-9

eBook (PDF) ISBN: 978-1-83962-135-2

Copyright year: 2019

Books open for chapter submissions

11397 Total Chapter Downloads

37 Crossref Citations

14 Web of Science Citations

84 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Immunity and Immunomodulation

By Rajeev K. Tyagi


Open access peer-reviewed

2. Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

By José Luis Muñoz-Carrillo, Juan Francisco Contreras-Cordero, Oscar Gutiérrez-Coronado, Paola Trinidad Villalobos-Gutiérrez, Luis Guillermo Ramos-Gracia and Viridiana Elizabeth Hernández-Reyes


Open access peer-reviewed

3. Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens

By Verónica Chico, Ivan Nombela, Sara Puente-Marín and María del Mar Ortega-Villaizan


Open access peer-reviewed

4. Multifunctional Activity of the β-Defensin-2 during Respiratory Infections

By Dora Patricia Rosete Olvera and Carlos Cabello Gutiérrez


Open access peer-reviewed

5. Immune Cell Activation: Stimulation, Costimulation, and Regulation of Cellular Activation

By Suman Kapur and Anuradha Pal


Open access peer-reviewed

6. Mesenchymal Stem Cells Modulate the Immune System in Developing Therapeutic Interventions

By Sonali Rawat, Suchi Gupta and Sujata Mohanty


Open access peer-reviewed

7. Current State of the Art in DNA Vaccine Delivery and Molecular Adjuvants: Bcl-xL Anti-Apoptotic Protein as a Molecular Adjuvant

By Sultan Gulce-Iz and Pelin Saglam-Metiner


Open access peer-reviewed

8. Role of Aryl Hydrocarbon-Ligands in the Regulation of Autoimmunity

By Hana’a Burezq


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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