Open access peer-reviewed Edited Volume

Approach Based on Phenotype and Endotype

Asthma Diagnosis and Management

Edited by Kuan-Hsiang Gary Huang

University of Oxford, United Kingdom


Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease "phenotype" and "endotype," which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.

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Asthma Diagnosis and ManagementEdited by Kuan-Hsiang Gary Huang

Published: July 4th 2018

DOI: 10.5772/intechopen.71160

ISBN: 978-1-78923-323-0

Print ISBN: 978-1-78923-322-3

eBook (PDF) ISBN: 978-1-83881-524-0

Copyright year: 2018

Books open for chapter submissions

9305 Total Chapter Downloads

3 Crossref Citations

4 Web of Science Citations

6 Dimensions Citations


Open access peer-reviewed

1. Noninvasive Biomarkers of Asthma

By Mirjana Turkalj, Damir Erceg and Iva Dumbović Dubravčić


Open access peer-reviewed

2. Epidemiological Aspects of Rhinitis and Asthma: Comorbidity or United Airway Disease

By Sanela Domuz Vujnovic and Adrijana Domuz


Open access peer-reviewed

3. Meaning of Endotype-Phenotype in Pediatric Respiratory Pathology

By Francisco Muñoz-López


Open access peer-reviewed

4. Functional Lung Examination in Diagnostics of Asthma and Its Phenotypes

By Frantisek Lopot, Vaclav Koucky, Daniel Hadraba, David Skalicky and Karel Jelen


Open access peer-reviewed

5. Asthma in the Disadvantaged: A Phenotype in Need of a Personalized, Multidisciplinary Approach to Therapy

By Drew A. Harris, Caitlin Welch, Morgan Soper and Yun Michael Shim


Open access peer-reviewed

6. Phosphodiesterase 3 and 4 Inhibition: Facing a Bright Future in Asthma Control

By Jan Beute, Vincent Manganiello and Alex KleinJan


Open access peer-reviewed

7. Subcellular Organelles in Immune Responses of Severe Asthma: The Roles of Mitochondria and Endoplasmic Reticulum

By Yong Chul Lee and So Ri Kim


Open access peer-reviewed

8. Severe Asthma: Updated Therapy Approach Based on Phenotype and Biomarker

By Marcia Regina Piuvezam, Laércia Karla Diega Paiva Ferreira, Talissa Mozzini Monteiro, Giciane Carvalho Vieira and Claudio Roberto Bezerra-Santos


Open access peer-reviewed

9. Monoclonal Antibodies for Asthma Management

By Dolly V. Rojas, Diana L. Silva and Carlos D. Serrano


Open access peer-reviewed

10. The Asthma Obese Phenotype

By Marina Ruxandra Oțelea and Agripina Rașcu


Open access peer-reviewed

11. Use of Omalizumab as Treatment in Patients with Moderate and Severe Non-Atopic Asthma and Associated with Asthma- COPD Overlap Syndrome (ACOS)

By Herrera García José Carlos, Arellano Montellano Ek Ixel, Jaramillo Arellano Luis Enrique, Espinosa Arellano Andrea, Martínez Flores Alejandra Guadalupe and Caballero López Christopherson Gengyny


Open access peer-reviewed

12. Cough Variant Asthma as a Phenotype of Classic Asthma

By Sanela Domuz Vujnović, Adrijana Domuz and Slobodanka Petrović


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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