Open access peer-reviewed Edited Volume


Physiology and Pathology

Edited by Maria Teresa Gentile

University of Campania "Luigi Vanvitelli", Italy


A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.

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AstrocytePhysiology and PathologyEdited by Maria Teresa Gentile

Published: March 21st 2018

DOI: 10.5772/intechopen.69076

ISBN: 978-953-51-3886-0

Print ISBN: 978-953-51-3885-3

eBook (PDF) ISBN: 978-953-51-4077-1

Copyright year: 2018

Books open for chapter submissions

10879 Total Chapter Downloads

8 Crossref Citations

11 Web of Science Citations

22 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: The Importance of Astrocytes in the Research of CNS Diseases

By Maria Teresa Gentile and Luca Colucci D’Amato


Open access peer-reviewed

2. Signaling Pathways Regulating the Pathophysiological Responses of Astrocytes: A Focus on the IKK/NF-κB System

By Michael Lattke and Thomas Wirth


Open access peer-reviewed

3. Evidence that Astroglia Influence Dendrite Morphogenesis and Synaptogenesis Independently in the Vertebrate Central Nervous System

By Christopher S. Wallace and Ginger S. Withers


Open access peer-reviewed

4. NMDA Receptors in Astroglia: Chronology, Controversies, and Contradictions from a Complex Molecule

By Pavel Montes de Oca Balderas and José Roberto González Hernández


Open access peer-reviewed

5. Astrocytes in Pathogenesis of ALS Disease and Potential Translation into Clinic

By Izrael Michal, Slutsky Shalom Guy, Joseph Itskovitz-Eldor and Revel Michel


Open access peer-reviewed

6. Astrocytes’ Role in Alzheimer’s Disease Neurodegeneration

By Ilaria Dal Prà, Ubaldo Armato and Anna Chiarini


Open access peer-reviewed

7. Mitochondrial Function in Alzheimer’s Disease: Focus on Astrocytes

By Riikka Lampinen, Irina Belaya, Isabella Boccuni, Tarja Malm and Katja M. Kanninen


Open access peer-reviewed

8. The Role of Astrocytes in Tumor Growth and Progression

By Emily Gronseth, Ling Wang, David R. Harder and Ramani Ramchandran


Open access peer-reviewed

9. Astrocytes in Aceruloplasminemia

By Hiroaki Miyajima


Open access peer-reviewed

10. Astrocyte Pathophysiology in Liver Disease

By Carlos Pérez-Monter and Aldo Torre-Delgadillo


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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