Open access peer-reviewed Edited Volume

Chagas Disease

Basic Investigations and Challenges


Helieh S. Oz

University of Kentucky, United States of America

This book contains 11 chapters of significant and updated materials on what we know and what we lack and need in better understanding of Trypanosoma cruzi - a parasite that never dies - and the consequences of Chagas disease as one of the most important neglected parasitic diseases threatening the global health and wellbeing. This book is intended to increase the readers' enthusiasm to explore the four sections of the contents: Section 1 begins with biochemistry, pathophysiology, histo-immunological study, and findings to assist in the diagnosis; Section 2 further investigates the role of vector in propagation of the parasite, the intensity on epidemiology, and the severity on clinical aspects, which help us to be well perceived on the course of disease; Section 3 is seeking beyond modern medicine and what lays in the nature that helps fight against this parasite; and the last section, Section 4, deals with the impacts of public health problem and the control strategies on Chagas disease.

Read more >Order hardcopy
Chagas DiseaseBasic Investigations and ChallengesEdited by Veeranoot Nissapatorn

Published: September 12th 2018

DOI: 10.5772/intechopen.69020

ISBN: 978-1-78923-659-0

Print ISBN: 978-1-78923-658-3

eBook (PDF) ISBN: 978-1-83881-369-7

Copyright year: 2018

Books open for chapter submissions

8562 Total Chapter Downloads

9 Crossref Citations

5 Web of Science Citations

14 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Chagas Disease and Its Global Impacts

By Frederick R. Masangkay, Giovanni DJ Milanez, Helieh S. Oz and Veeranoot Nissapatorn


Open access peer-reviewed

2. Biochemical, Cellular, and Immunologic Aspects during Early Interaction between Trypanosoma cruzi and Host Cell

By Rosa Lidia Solís-Oviedo, Víctor Monteon, Ruth López and Ángel de la Cruz Pech-Canul


Open access peer-reviewed

3. Antiparasitic Mechanisms of the Human Placenta

By Castillo Christian, Ana Liempi, Lisvaneth Medina, Ileana Carrillo and Ulrike Kemmerling


Open access peer-reviewed

4. The Mouse Model as a Tool for Histological, Immunological and Parasitological Studies of Trypanosoma cruzi Infection

By María Elena Villagran-Herrera, José Alejandro Martínez-Ibarra, Manuel Sánchez-Moreno, Hebert Luis Hernández-Montiel, Ricardo Francisco Mercado-Curiel, Nicolás Camacho-Calderón and José Antonio de Diego-Cabrera


Open access peer-reviewed

5. Transmitter Insect of Chagas Disease in Northwest Mexico: A Comparative Study of the Cuticular Hydrocarbons Profile of Three Populations of Triatoma rubida: Peridomestic, Domestic and Sylvatic

By Edgar Alfonso Paredes González, Gerardo Álvarez Hernandez and Jesús Ortega-García


Open access peer-reviewed

6. Eco-Epidemiology of Chagas Disease in Chile

By Mauricio Canals Lambarri, Andrea Canals Cifuentes, Salvador Ayala, Valentina Tapia-Garay and Dante Cáceres Lillo


Open access peer-reviewed

7. Chagas Cardiomyopathy: Role of Sustained Host-Parasite Interaction in Systemic Inflammatory Burden

By Rodolfo A Kölliker-Frers, Matilde Otero-Losada, Gabriela Razzitte, Mariela Calvo, Justo Carbajales and Francisco Capani


Open access peer-reviewed

8. Efficacy and Safety of Chagas Disease Drug Therapy and Treatment Perspectives

By Wilton H. Kawaguchi, Leticia Bonancio Cerqueira, Mariana Millan Fachi, Michel L. Campos, Iara J. Messias Reason and Roberto Pontarolo


Open access peer-reviewed

9. New Approaches for Chagas’ Disease Chemotherapy

By Guadalupe García Liñares


Open access peer-reviewed

10. Slowed Development of Natural Products for Chagas Disease, how to Move Forward?

By Javier Varela, Hugo Cerecetto and Mercedes González


Open access peer-reviewed

11. Silent Information Regulator 2 from Trypanosoma cruzi Is a Potential Target to Infection Control

By Luís Gaspar, Terry K. Smith, Nilmar Silvio Moretti, Sergio Schenkman and Anabela Cordeiro-da-Silva


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£119

Order now

Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase