Open access peer-reviewed Edited Volume

Endothelial Dysfunction

Old Concepts and New Challenges

Edited by Helena Lenasi

University of Ljubljana, Slovenia

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

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Endothelial DysfunctionOld Concepts and New ChallengesEdited by Helena Lenasi

Published: October 24th 2018

DOI: 10.5772/intechopen.68656

ISBN: 978-1-78984-254-8

Print ISBN: 978-1-78984-253-1

eBook (PDF) ISBN: 978-1-83881-339-0

Copyright year: 2018

Books open for chapter submissions

19409 Total Chapter Downloads

31 Crossref Citations

20 Web of Science Citations

53 Dimensions Citations


Open access peer-reviewed

1. Endothelium at a Glance

By Helena Lenasi


Open access peer-reviewed

2. Hox Genes in Adult Tissues and Their Role in Endothelial Cell Differentiation and Angiogenesis

By Estefanía Nova-Lampeti, Valeria Aguilera, Katherine Oporto, Paula Guzmán, Valeska Ormazábal, Felipe Zúñiga, Carlos Escudero and Claudio Aguayo


Open access peer-reviewed

3. Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction

By Julia Carracedo, Rafael Ramírez-Carracedo, Matilde Alique and Rafael Ramírez-Chamond


Open access peer-reviewed

4. Targeting Endothelial SIRT1 for the Prevention of Arterial Aging

By Yumeng Guo and Yu Wang


Open access peer-reviewed

5. Sensing Fluid-Shear Stress in the Endothelial System with a Special Emphasis on the Primary Cilium

By Meriem Rezgaoui, Andres Rodriguez, Kurt Herlitz and Carlos Escudero


Open access peer-reviewed

6. Endothelial Dysfunction as a Consequence of Endothelial Glycocalyx Damage: A Role in the Pathogenesis of Preeclampsia

By Marina M. Ziganshina, Ekaterina L. Yarotskaya, Nicolai V. Bovin and Gennady T. Sukhikh


Open access peer-reviewed

7. Endothelial Cell von Willebrand Factor Secretion in Health and Cardiovascular Disease

By Luiza Rusu and Richard D. Minshall


Open access peer-reviewed

8. Hyperglycemia-Induced Endothelial Dysfunction

By Domokos Gero


Open access peer-reviewed

9. Impact of Advanced Glycation End Products on Endothelial Function and Their Potential Link to Atherosclerosis

By Ezequiel Alvarez, Beatriz Paradela-Dobarro, Mercedes González- Peteiro and José Ramón González-Juanatey


Open access peer-reviewed

10. Endothelial Dysfunction in Type 2 Diabetes: Targeting Inflammation

By Cristina M. Sena, Fernanda Carrilho and Raquel M. Seiça


Open access peer-reviewed

11. Angiogenesis in Adipose Tissue: How can Moderate Caloric Restriction Affects Obesity-Related Endothelial Dysfunction?

By Katarzyna Korybalska


Open access peer-reviewed

12. Pulmonary Vascular Endothelial Cells

By Joyce N. Gonzales and Alexander D. Verin


Open access peer-reviewed

13. Smoking, Respiratory Diseases and Endothelial Dysfunction

By Vera Nevzorova, Tatiana Brodskaya and Natalia Zakharchuk


Open access peer-reviewed

14. Vascular Sympathetic Neurotransmission and Endothelial Dysfunction

By Joana Sousa and Carmen Diniz


Open access peer-reviewed

15. Endothelial Cell Dysfunction in HIV-1 Infection

By Pietro Mazzuca, Arnaldo Caruso and Francesca Caccuri


Open access peer-reviewed

16. Selected Endothelial Responses after Ionizing Radiation Exposure

By Bjorn Baselet, Raghda Ramadan, Abderrafi Mohammed Benotmane, Pierre Sonveaux, Sarah Baatout and An Aerts


Open access peer-reviewed

17. The Markers of Endothelial Activation

By Ines Drenjancevic, Ivana Jukic, Ana Stupin, Anita Cosic, Marko Stupin and Kristina Selthofer-Relatic


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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