Open access peer-reviewed Edited Volume


Current State and Recent Updates

Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma.

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NeuroblastomaCurrent State and Recent UpdatesEdited by Chandrika Gowda

Published: October 25th 2017

DOI: 10.5772/66615

ISBN: 978-953-51-3584-5

Print ISBN: 978-953-51-3583-8

eBook (PDF) ISBN: 978-953-51-4619-3

Copyright year: 2017

Books open for chapter submissions

10152 Total Chapter Downloads

4 Crossref Citations

5 Web of Science Citations

8 Dimensions Citations


Open access peer-reviewed

1. Neuroblastoma: The Clinical Aspects

By Neema Bhat and Lisa McGregor


Open access peer-reviewed

2. The Origin of Neuroblastoma

By Gian Paolo Tonini


Open access peer-reviewed

3. Anatomic Origin and Molecular Genetics in Neuroblastoma

By Murat Tosun, Hamit Selim Karabekir, Mehmet Ozan Durmaz, Harun Muayad Said, Yasemin Soysal and Nuket Gocmen Mas


Open access peer-reviewed

4. Target Therapy in Neuroblastoma

By Tamer Hassan, Mohamed Badr, Usama El Safy, Mervat Hesham, Laila Sherief, Mohamed Beshir, Manar Fathy, Mohamed Al Malky and Marwa Zakaria


Open access peer-reviewed

5. Molecular Approach to Neuroblastoma

By Bakiye Goker Bagca and Cigir Biray Avci


Open access peer-reviewed

6. Telomeres and Telomerase in Neuroblastoma

By Joëlle El Hajj, Delphine Garsuault, Claire Bouyer, Eric Nguyen, George Hilal and Evelyne Ségal-Bendirdjian


Open access peer-reviewed

7. Epigenetic Approaches in Neuroblastoma Disease Pathogenesis

By Francesca Felicia Caputi, Sanzio Candeletti and Patrizia Romualdi


Open access peer-reviewed

8. Considerations for the Development of Innovative Therapies Against Aggressive Neuroblastoma: Immunotherapy and Twist1 Targeting

By Tala Shekarian and Sandrine Valsesia‐Wittmann


Edited Volume and chapters are indexed in

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  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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