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Open access peer-reviewed Edited Volume

A Master Regulator of Oxidative Stress

The Transcription Factor Nrf2

Edited by Jose Antonio Morales-Gonzalez

Instituto Politécnico Nacional


Ángel Morales-González

Instituto Politécnico Nacional

Eduardo Osiris Madrigal-Santillan

Instituto Politécnico Nacional

Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

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The Transcription Factor Nrf2Edited by Jose Antonio Morales-Gonzalez

Published: December 21st 2016

DOI: 10.5772/62743

ISBN: 978-953-51-2838-0

Print ISBN: 978-953-51-2837-3

eBook (PDF) ISBN: 978-953-51-5462-4

Copyright year: 2016

Books open for chapter submissions

23109 Total Chapter Downloads

33 Crossref Citations

26 Web of Science Citations

77 Dimensions Citations


Open access peer-reviewed

1. Endogenous Antioxidants: A Review of their Role in Oxidative Stress

By Tomás Alejandro Fregoso Aguilar, Brenda Carolina Hernández Navarro and Jorge Alberto Mendoza Pérez


Open access peer-reviewed

2. NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response

By Ting-Yu Lin, Lewis C. Cantley and Gina M. DeNicola


Open access peer-reviewed

3. Multiple Modes of Nrf2 Regulation and Transcriptional Response

By Sherin T. Mathew and Ola Hammarsten


Open access peer-reviewed

4. Feed-Forward and Feed-Back Circuits of the NRF2/AP-1 Composite Pathway

By Peter V. Zolotukhin and Anna A. Belanova


Open access peer-reviewed

5. Nrf2 Contributes to the Poor Prognosis and Chemoresistance

By Jhih-Pu Syu, Jen-Tsan Chi and Hsiu-Ni Kung


Open access peer-reviewed

6. Possible Role of Nrf2 in Oxidative and Inflammatory Processes During Menopause

By Claudia C. Calzada Mendoza, Carlos A. Jiménez Zamarripa, María E. Ocharán Hernández and Gisela Gutiérrez Iglesias


Open access peer-reviewed

7. The Effect of Nrf2 on Diabetic Complications

By Angela Adamski da Silva Reis, Rodrigo da Silva Santos, Aline Helena da Silva Cruz, Elisangela Gomes da Silva, Aparecido Divino da Cruz and Gustavo Rodrigues Pedrino


Open access peer-reviewed

8. Nrf2 Signaling: An Adaptive Response Pathway for Neurodegenerative Disorders

By Annalisa Lo Gerfo, Lucia Petrozzi, Lucia Chico and Gabriele Siciliano


Open access peer-reviewed

9. Nrf2 and Parkinson’s Disease

By Michael Todorovic and George D. Mellick


Open access peer-reviewed

10. Oxidative Stress and Disease

By Rosângela F.F de Araújo, Danyelly Bruneska G. Martins and Maria Amélia C.S.M. Borba


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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