Open access peer-reviewed Edited Volume


A Complex End of a Chromosome

Edited by Marcelo L. Larramendy

National University of La Plata

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

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TelomereA Complex End of a ChromosomeEdited by Marcelo L. Larramendy

Published: November 23rd 2016

DOI: 10.5772/60625

ISBN: 978-953-51-2753-6

Print ISBN: 978-953-51-2752-9

eBook (PDF) ISBN: 978-953-51-4150-1

Copyright year: 2016

Books open for chapter submissions

14351 Total Chapter Downloads

4 Crossref Citations

8 Web of Science Citations

16 Dimensions Citations


Open access peer-reviewed

1. Telomeres in Liver Transplantation Allografts

By Tatsuaki Tsuruyama and Wulamujiang Aini


Open access peer-reviewed

2. Telomere and Telomerase in Cancer

By Angayarkanni Jayaraman, Kalarikkal Gopikrishnan Kiran and Palaniswamy Muthusamy


Open access peer-reviewed

3. Telomeres and Genomic Instability from Precancerous Lesions to Advanced Cancer – Understanding Through Ovarian Cancer

By Gautier Chene, Gery Lamblin, Karine Le Bail-Carval, Philippe Chabert, Georges Mellier and Andrei Tchirkov


Open access peer-reviewed

4. The Role of Telomeres and Telomere-associated Proteins as Components of Interactome in Cell-signaling Pathways

By Ekta Khattar and Vinay Tergaonkar


Open access peer-reviewed

5. Molecular Diagnosis and Precision Therapeutic Approaches for Telomere Biology Disorders

By Rosario Perona, Laura Iarriccio, Laura Pintado-Berninches, Javier Rodriguez-Centeno, Cristina Manguan-Garcia, Elena Garcia, Blanca Lopez-Ayllón and Leandro Sastre


Open access peer-reviewed

6. Telomere Instability Induced by Anticancer Drugs in Mammalian Cells

By Alejandro D. Bolzán


Open access peer-reviewed

7. Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases

By Ryusaku Matsumoto and Yutaka Takahashi


Open access peer-reviewed

8. Telomere Length and Its Relation to Human Health

By Vivian F. S. Kahl and Juliana da Silva


Open access peer-reviewed

9. On the Far Side of Telomeres: The Many Roles of Telomerase in the Acquisition and Retention of Cancer Stemness

By Kerem Teralı and Açelya Yilmazer


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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