Open access peer-reviewed Edited Volume

Calcific Aortic Valve Disease

Edited by Elena Aikawa

Brigham and Women's Hospital, United States of America

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

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Calcific Aortic Valve DiseaseEdited by Elena Aikawa

Published: June 12th 2013

DOI: 10.5772/46239

ISBN: 978-953-51-1150-4

eBook (PDF) ISBN: 978-953-51-7163-8

Copyright year: 2013

Books open for chapter submissions

50342 Total Chapter Downloads

34 Crossref Citations

53 Web of Science Citations

76 Dimensions Citations


Open access peer-reviewed

1. Extracellular Matrix Organization, Structure, and Function

By Dena Wiltz, C. Alexander Arevalos, Liezl R. Balaoing, Alicia A. Blancas, Matthew C. Sapp, Xing Zhang and K. Jane Grande-Allen


Open access peer-reviewed

2. Anatomy and Function of Normal Aortic Valvular Complex

By Ioan Tilea, Horatiu Suciu, Brindusa Tilea, Cristina Maria Tatar, Mihaela Ispas and Razvan Constantin Serban


Open access peer-reviewed

3. Developmental Pathways in CAVD

By Elaine E. Wirrig and Katherine E. Yutzey


Open access peer-reviewed

4. Notch Signaling in Congenital and Acquired Aortic Valve Disease

By Erik Fung and Masanori Aikawa


Open access peer-reviewed

5. Role of MicroRNAs in Cardiovascular Calcification

By Claudia Goettsch and Elena Aikawa


Open access peer-reviewed

6. Proteomics and Metabolomics in Aortic Stenosis: Studying Healthy Valves for a Better Understanding of the Disease

By L. Mourino-Alvarez, C.M. Laborde and M.G. Barderas


Open access peer-reviewed

7. Genetics of Bicuspid Aortic Valve and Calcific Aortic Valve Disease

By Robert B. Hinton


Open access peer-reviewed

8. The Immune Response in In Situ Tissue Engineering of Aortic Heart Valves

By S. L. M. van Loon, A. I. P. M. Smits, A. Driessen-Mol, F. P. T. Baaijens and C. V. C. Bouten


Open access peer-reviewed

9. Cutting-Edge Regenerative Medicine Technologies for the Treatment of Heart Valve Calcification

By Laura Iop and Gino Gerosa


Open access peer-reviewed

10. Bicuspid Aortic Valve

By George Tokmaji, Berto J. Bouma, Dave R. Koolbergen and Bas A.J.M. de Mol


Open access peer-reviewed

11. The Bicuspid Aortic Valve

By Mehmet Demir


Open access peer-reviewed

12. Surgical Valve Replacement (Bioprosthetic vs. Mechanical)

By Stamenko Šušak, Lazar Velicki, Dušan Popović and Ivana Burazor


Open access peer-reviewed

13. Current Treatment Options in Aortic Stenosis

By Fahrettin Oz, Fatih Tufan, Ahmet Ekmekci, Omer A. Sayın and Huseyin Oflaz


Open access peer-reviewed

14. Stentless Bioprostheses for Aortic Valve Replacement in Calcific Aortic Stenosis

By Kaan Kirali


Open access peer-reviewed

15. New Therapeutic Approaches to Conventional Surgery for Aortic Stenosis in High-Risk Patients

By Omer Leal, Juan Bustamante, Sergio Cánovas and Ángel G. Pinto


Open access peer-reviewed

16. Indications for Transcatheter Aortic Valve Implantation

By Ibrahim Akin, Stephan Kische, Henrik Schneider, Tim C. Rehders, Christoph A. Nienaber and Hüseyin Ince


Open access peer-reviewed

17. Aortic Valve Replacement for Calcified Aortic Valves

By Kazumasa Orihashi


Open access peer-reviewed

18. Congenital Aortic Stenosis in Children

By Hirofumi Saiki and Hideaki Senzaki


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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