Open access peer-reviewed Edited Volume


Edited by Rajnikant Mishra

Banaras Hindu University, India

The complexity of problem understanding biochemical and molecular basis of healthy life, and eagerness to find simple solution necessitate evolution of technology like mutagenesis. The chapters of this book contain experiences of scientists working in the area of mutagenesis. It describes suitable experimental models (microorganism, plants or animals) for testing spontaneous and induced mutations which are useful for basic and translational research. It includes methods towards gene targeting, developing disease and pest resistant plants, creating temperature sensitive molecular machines, understanding mitochondrial mutagenesis, detecting anti-mutagens, improving genetic insight into impaired immunity and disease. It also describes mutagenesis induced by DNA damage. It has also provided advantage of in vitro transcription and translation to yield proteins with point mutations, deletions or insertions for studying stability, DNA-protein or protein-protein interaction. Trust, it will serve readers as valuable integrated resources emphasizing methods of mutagenesis, and understanding mechanism of variable penetrance or expressivity of mutations.

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MutagenesisEdited by Rajnikant Mishra

Published: August 17th 2012

DOI: 10.5772/2937

ISBN: 978-953-51-0707-1

eBook (PDF) ISBN: 978-953-51-5312-2

Copyright year: 2012

Books open for chapter submissions

29501 Total Chapter Downloads

12 Crossref Citations

21 Web of Science Citations

30 Dimensions Citations


Open access peer-reviewed

1. Mutagenesis: A Useful Tool for the Genetic Improvement of the Cultivated Peanut (Arachis hypogaea L.)

By Chuan Tang Wang, Yue Yi Tang, Xiu Zhen Wang, Qi Wu, Hua Yuan Gao, Tong Feng, Jun Wei Su, Shu Tao Yu, Xian Lan Fang, Wan Li Ni, Yan Sheng Jiang, Lang Qian and Dong Qing Hu


Open access peer-reviewed

2. Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis

By Fusao Hirata, George B. Corcoran and Aiko Hirata


Open access peer-reviewed

3. Models for Detection of Genotoxicity in vivo: Present and Future

By Cherie Musgrove and Manel Camps


Open access peer-reviewed

4. Mitochondrial Mutagenesis in Aging and Disease

By Marc Vermulst, Konstantin Khrapko and Jonathan Wanagat


Open access peer-reviewed

5. Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

By Biljana Nikolić, Dragana Mitić-Ćulafić, Branka Vuković-Gačić and Jelena Knežević-Vukčević


Open access peer-reviewed

6. Chemical Modification of Oligonucleotides: A Novel Approach Towards Gene Targeting

By Hidetaka Torigoe and Takeshi Imanishi


Open access peer-reviewed

7. The Mutation of Transient Receptor Potential Vanilloid 4 (TRPV4) Cation Channel in Human Diseases

By Sang Sun Kang


Open access peer-reviewed

8. Bacterial Systems for Testing Spontaneous and Induced Mutations

By Anna Sikora, Celina Janion and Elżbieta Grzesiuk


Open access peer-reviewed

9. ENU Mutagenesis in Mice - Genetic Insight into Impaired Immunity and Disease

By Kristin Lampe, Siobhan Cashman, Halil Aksoylar and Kasper Hoebe


Open access peer-reviewed

10. Mutagenesis in Plant Breeding for Disease and Pest Resistance

By Petra Kozjak and Vladimir Meglič


Open access peer-reviewed

11. Mutagenesis and Temperature-Sensitive Little Machines

By María Pertusa, Hans Moldenhauer, Sebastián Brauchi, Ramón Latorre, Rodolfo Madrid and Patricio Orio


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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