Open access peer-reviewed Edited Volume

Fundamental Aspects of DNA Replication

DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed. We hope that readers will find this book interesting, helpful and inspiring.

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Fundamental Aspects of DNA ReplicationEdited by Jelena Kusic-Tisma

Published: September 26th 2011

DOI: 10.5772/766

ISBN: 978-953-307-259-3

eBook (PDF) ISBN: 978-953-51-5157-9

Copyright year: 2011

Books open for chapter submissions

44323 Total Chapter Downloads

7 Crossref Citations

15 Web of Science Citations

18 Dimensions Citations


Open access peer-reviewed

1. Assembly and Regulation of the Pre-Replication Complex: Increasing Complexity in Sight of Diversified Function and Regulation

By Malik Lutzmann


Open access peer-reviewed

2. Regulation of DNA Replication Origin Licensing

By Srikripa Chandrasekaran, Karen T. Reidy and Jeanette Gowen Cook


Open access peer-reviewed

3. Addressing the Enigma of MCM8 in DNA Replication

By Dianne C. Daniel and Edward M. Johnson


Open access peer-reviewed

4. Regulation of MCM7 DNA Replication Licensing Activity

By Jian-Hua Luo and Yan P. Yu


Open access peer-reviewed

5. Regulation of Minichromosome Maintenance (MCM) Helicase in Response to Replication Stress

By Faria Zafar and Takuro Nakagawa


Open access peer-reviewed

6. Cell Cycle Control of DNA Replication by Phosphorylation and Dephosphorylation of Replication-Initiation Proteins in Budding Yeast

By Yuanliang Zhai, Philip Y.K. Yung and Chun Liang


Open access peer-reviewed

7. Cdc6 Knockdown Renders p16INK4a Re-Activation, Leading to Senescence Human Breast Carcinoma Cells

By Luo Feng, Jerry R. Barnhart, Lingtao Wu, Greg Shackleford, Sheng-he Huang and Ambrose Jong


Open access peer-reviewed

8. Visualize Dynamics of Chromosome Structure Formation and DNA Repair/Recombination Coupled With DNA Replication: Tight Coupled Role of DNA Replication in Chromosome Compaction and DNA Recombination

By Eisuke Gotoh


Open access peer-reviewed

9. Sequence-Directed DNA Curvature in Replication Origins Segments

By Adriana Fiorini, Fabrícia Gimenes, Quirino Alves de Lima Neto, Fábio Rogério Rosado and Maria Aparecida Fernandez


Open access peer-reviewed

10. Initiation of DNA Replication from Closed Circular DNA

By Daniel Simmons


Open access peer-reviewed

11. Function of DNA Polymerase α in a Replication Fork and its Putative Roles in Genomic Stability and Eukaryotic Evolution

By Masaharu Takemura


Open access peer-reviewed

12. Quality Control of DNA Polymerase α

By Takeshi Mizuno, Masako Izumi and Christian S. Eichinger


Open access peer-reviewed

13. Mechanisms and Controls of DNA Replication in Bacteria

By César Quiñones-Valles, Laura Espíndola-Serna and Agustino Martínez-Antonio


Open access peer-reviewed

14. Propagating Epigenetic States During DNA Replication

By Jennifer L. Jacobi and Ann L. Kirchmaier


Open access peer-reviewed

15. Epigenetic Modifications: Genetic Basis of Environmental Stress Response

By Takeo Kubota, Kunio Miyake and Takae Hirasawa


Open access peer-reviewed

16. Relations Between Replication and Transcription

By Daniel Castro-Roa and Nikolay Zenkin


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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