Open access peer-reviewed Edited Volume

Gastrointestinal Stromal Tumor

Edited by Raimundas Lunevicius

King's College Hospital NHS Foundation Trust, United Kingdom

Almost 30 years have gone by since the postulation that GISTs derive from mesenchymal stem elements, and only 15 years have gone by since the definitive detection of origin of GISTs. Research in the last decade was more focused upon the justification of imatinib mezylate therapy in GISTs and clarification why a secondary resistance that occurred during the kinase inhibitors therapy. The era of therapy for GISTs, targeting the primary activating mutations in the KIT proto-oncogene; is being proclaimed as bringing the message of special importance to the pathologist role in multidisciplinary team that are responsible for treating patients with locally advanced or metastatic GIST. This is the first conclusive message forthcoming from this book. On the other hand, the book provides summarised and case-based knowledge on current management of gastrointestinal and extragastrointestinal stromal tumours. We hope that this book may be considered as a worthwhile timely addition to clinical science dissemination, medical education, further basic and clinical research.

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Gastrointestinal Stromal TumorEdited by Raimundas Lunevicius

Published: April 27th 2012

DOI: 10.5772/1892

ISBN: 978-953-51-0580-0

eBook (PDF) ISBN: 978-953-51-6987-1

Copyright year: 2012

Books open for chapter submissions

13520 Total Chapter Downloads

2 Web of Science Citations

1 Dimensions Citations


Open access peer-reviewed

1. GISTs: From the History to the Tailored Therapy

By Roberta Zappacosta, Barbara Zappacosta, Serena Capanna, Chiara D'Angelo, Daniela Gatta and Sandra Rosini


Open access peer-reviewed

2. Treatment Options for Gastrointestinal Stromal Tumors

By Kai-Hsi Hsu


Open access peer-reviewed

3. Molecularly Targeted Therapy: Imatinib and Beyond

By Andrew Poklepovic and Prithviraj Bose


Open access peer-reviewed

4. Surgical Treatment of Gastrointestinal Stromal Tumors (GISTs)

By António M. Gouveia and José Manuel Lopes


Open access peer-reviewed

5. The Role of the Surgeon in Multidisciplinary Approach to Gastrointestinal Stromal Tumors

By Selim Sözen, Ömer Topuz and Yasemin Benderli Cihan


Open access peer-reviewed

6. Gastrointestinal Stromal Tumor of the Rectovaginal Septum, a Diagnosis Challenge

By Josefa Marcos Sanmartin, Maria Jose Roman Sanchez, Jose Antonio Lopez Fernandez, Óscar Pinero Sanchez, Amparo Candela Hidalgo, Hortensia Ballester Galiana, Natalia Esteve Fuster, Aranzazu Saco Lopez and Juan Carlos Martínez Escoriza


Open access peer-reviewed

7. The Significance of the Ki-67 Labeling Index, the Expression of c-kit, p53, and bcl-2, and the Apoptotic Count on the Prognosis of Gastrointestinal Stromal Tumor

By Keishiro Aoyagi, Kikuo Kouhuji and Kazuo Shirouzu


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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