Usman Sumo Friend Tambunan

University of Indonesia

Usman Sumo Friend Tambunan is Professor of the Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Indonesia since 1997. He earned his doctoral degree in Chemistry from Tohoku University, Japan in 1986. Afterward, he carried out postdoctoral research at Kansas University, USA and in Taiwan. Since then, he has been a lecturer for Organic Chemistry and Biochemistry at Universitas Indonesia. Prof. Tambunan research interests focus on drug and vaccine design using computational method for avian influenza, ebola virus, dengue virus, and cervical cancer. His research includes the development of natural products, cyclic peptides, and fragment-based drug design to find a drug candidate to combat these diseases. For his research achievement and dedication, he has been rewarded with Satya Lencana in 2010 and 3rd Best Professor at Universitas Indonesia in 2009.

1books edited

3chapters authored

Latest work with IntechOpen by Usman Sumo Friend Tambunan

Peptides are the biomolecules that consist of several amino acid chains linked through peptide bonds. This class of biomolecules is commonly found in living matter, and some of which play an imperative role in their regulation and functional activities. Peptides have been extensively applied in every aspect of human life, including cosmetics, electronics, the food industries, and pharmaceutical fields. Ultimately, peptide commercialization has become a major trend, which has been growing significantly in recent years. Viewed from the scientific perspective described above, the editor believes that the development of peptides in every aspect of human life should be accelerated. As such, this book aims to provide insight and knowledge regarding the current research that has been conducted in this field; hence, this book may encourage the reader to emphasize the importance of peptides in human life and to inspire others to identify the potency of peptides for other applications that still need further exploration. In this book, some of the compelling applications of peptides in biological and health sciences will be introduced. This book comprises an introductory chapter, along with four chapters presented by several prominent scientists who work in the field of peptide research.

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Polypeptide

Edited by Usman Sumo Friend Tambunan

Chapters authored

HPV Bioinformatics: In Silico Detection, Drug Design and Prevention Agent Development

By Usman Sumo Friend Tambunan and Arli Aditya Parikesit

Part of the book: Topics on Cervical Cancer With an Advocacy for Prevention

Bioinformatics Approach to Screening and Developing Drug against Ebola

By Usman Sumo Friend Tambunan, Ahmad Husein Alkaff and Mochammad Arfin Fardiansyah Nasution

Ebola is an acute disease causing hemorrhagic fever marked with high mortality rate. The patients who suffer from Ebola only receive palliative care because there is no available drug which can consistently cure this disease. To date, no cure has been found to treat this disease. Bioinformatics and computer-aided drug discovery and development (CADDD) are employed to utilize the readily available genomic and proteomic data and enhance the hit rate of the novel and repurposed drug for Ebola therapy. Additionally, the time and cost of wet laboratory experiments can be drastically reduced by the support of bioinformatics approach. Our laboratory has succeeded not only in creating the bioinformatics research pipeline but also screening and developing the drug candidate to cure Ebola. Through pharmacophore-based virtual screening and molecular docking simulations, we discovered that about three Indonesian natural product compounds have noteworthy molecular interactions against EBOV VP35 protein, which are responsible for the RNA synthesis of the Ebola. These compounds can be reevaluated further through advances in in silico simulation and in vitro experiments.

Part of the book: Advances in Ebola Control

Introductory Chapter: Application of Peptides in Biomedical Sciences

By Usman Sumo Friend Tambunan, Mochammad Arfin Fardiansyah Nasution and Ahmad Husein Alkaff

Part of the book: Polypeptide

Usman Sumo Friend Tambunan

Latest work with IntechOpen by Usman Sumo Friend Tambunan

Polypeptide

Chapters authored

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