Jixin Zhong

Education and Professional Experiences: 1999 ~ 2004 Tongji Medical College of Huazhong University of Science and Technology (HUST), MD 2004 ~ 2009 Tongji Medical College of Huazhong University of Science and Technology (HUST), PhD in immunology 2007 ~ 2010 Medical College of Georgia 2010 ~ 2011 Medical College of Georgia 2011 ~ present The Ohio State University Publication: 1. Zhong J, Rao X, Deiuliis J, Braunstein Z, …, Rajagopalan S. A Potential Role for DC/Macrophage-expressing DPP4 in Obesity-induced Visceral Inflammation. Diabetes. 2012 2. Zhong J, Rao X, Xu JF, Yang P, and Wang CY. The role of endoplasmic reticulum (ER) stress in autoimmune-mediated beta cell destruction in type 1 diabetes. Experimental Diabetes Research. 2012. 3. Rao X, Zhong J, Zhang S, Zhang Y, Yu Q, Yang P, Wang MH, Fulton DJ, Shi H, Dong Z, Wang D, and Wang CY. Loss of Methyl-CpG-Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury. Circulation. 2011. 4. Shah Z, Kampfrath T, Deiuliis JA, Zhong J, … Rajagopalan S. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation, 2011. 5. Deiuliis JA, Kampfrath T, Zhong J, Oghumu S, Maiseyeu A, Chen LC, Sun Q, Satoskar AR, Rajagopalan S. Pulmonary T cell Activation in Response to Chronic Particulate Air Pollution. Am J Physiol Lung Cell Mol Physiol. 2011. 6. Pang J, Zhang S, Yang P, Hawkins-Lee B, Zhong J, Zhang Y, Ochoa B, Agundez JA, Voelckel MA, Gu W, Xiong WC, Mei L, She JX, Wang CY. Loss-of-Function Mutations in HPSE2 Cause the Autosomal Recessive Urofacial Syndrome. Am J Hum Genet. 2010; 86(6):957-62. 7. Zhong J, Yang P, Muta K, Dong R, Marrero M, Gong F, and Wang CY. Loss of Jak2 Selectively Suppresses DC-Mediated Innate Immune Response and Protects Mice from Lethal Dose of LPS-Induced Septic Shock. PLoS One. 2010; 5(3): e9593 8. Zhang S*, Zhong J*, Yang P, Gong F, Wang CY. HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes. Int J Clin Exp Pathol. 2009 Sep 8;3(1):24-38. (co-first author) 9. Han J, Zhong J, Wei W, Wang Y, Huang Y, Yang P, Purohit S, Dong Z, Wang MH, She JX, Gong F, Stern DM, Wang CY. Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice. Diabetes. 2008 Aug;57(8):2118-27. 10. Yu G, Fang M, Gong M, Liu L, Zhong J, Feng W, Xiong P, Wang CY, Gong F. Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Transpl Immunol. 2008 Jan;18(3):208-19. Book chapter: 1.Jixin Zhong, Ping Yang, Feili Gong and Cong-Yi Wang. SUMO4-Encoded Genetic Susceptibility to Type 1 Diabetes. pp. 273-299. In: SUMO Regulation of Cellular Processes. Van Wilson, eds, Springler Publishing Inc., 2009. 2.Jixin Zhong, Ping Yang, and Cong-Yi Wang. Environmental Triggers and Endogenous Alarmins Linking Innate Immunity to the Pathogenesis of Type 1 Diabetes; pp. 177-206. In: Type 1 Diabetes Mellitus: Etiology, Diagnosis and Treatment. Frank Columbus, eds, Nova Science Publishers, Inc., 2009. 3.Jixin Zhong, Jun-Fa Xu, Ping Yang, Yi Liang and Cong-Yi Wang. Innate immunity in the recognition of β-cell antigens in type 1 diabetes. In: Type 1 Diabetes / Book 1 (ISBN 978-953-307-362-0). InTech Publishers. In press. Research interests: Innate immunity, Immune regulation, Inflammatory diseases, autoimmune disease.