Gabriela Da Silva Xavier

Imperial College London United Kingdom

My research interest is in the fuel sensing protein kinases - AMP-activated protein kinase (AMPK) and PAS-domain containing protein kinase (PASK)- and their roles in pancreatic endocrine cell function and development. I completed my PhD in Biochemistry at the University of Bristol in 2001. After two postdoctoral positions at the University of Bristol, I moved to Imperial College in 2006 where I was appointed lecturer in 2008 and have been involved in collaborative efforts to elucidate how the Type 2 Diabetes genes identified by Genome Wide Association Studies - TCF7L2, SLC30A8, WFS1, and HHEX - may affect beta-cell function and development. My work has been funded by the Juvenile Diabetes Research Foundation and European Foundation for the Study of Diabetes.

2books edited

1chapters authored

Latest work with IntechOpen by Gabriela Da Silva Xavier

Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.

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