John Chan

University of Montreal Canada

Dr. Chan is currently a Professor of Medicine at the Université de Montréal and the Chief of the Laboratory of Molecular Nephrology and Endocrinology at the Research Centre of Centre hospitalier de l’Université de Montréal (CRCHUM). Dr. Chan’s research program seeks to understand the role(s) of intrarenal renin angiotensin system (RAS) and oxidative stress in the pathogenesis of diabetic nephropathy, with special emphasis on renal angiotensinogen gene expression and reactive oxygen species (ROS) generation on tubular apoptosis in diabetes. Dr. Chan has published over 100 papers in scientific journals and presented more than 250 abstracts in various scientific societies. Dr. Chan’s research program is supported by several peer-reviewed granting agencies including the Canadian Institutes of Health Research, Kidney Foundation of Canada, Canadian Diabetes Association and Canadian Foundation of Innovation.

1books edited

1chapters authored

Latest work with IntechOpen by John Chan

Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy

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